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Fusion gene ID: 18755 |
FusionGeneSummary for KIAA1737_NGFR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIAA1737_NGFR | Fusion gene ID: 18755 | Hgene | Tgene | Gene symbol | KIAA1737 | NGFR | Gene ID | 85457 | 4804 |
| Gene name | CLOCK interacting pacemaker | nerve growth factor receptor | |
| Synonyms | KIAA1737 | CD271|Gp80-LNGFR|TNFRSF16|p75(NTR)|p75NTR | |
| Cytomap | 14q24.3 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CLOCK-interacting pacemakerCLOCK-interacting circadian proteinCLOCK-interacting protein, circadian | tumor necrosis factor receptor superfamily member 16NGF receptorTNFR superfamily, member 16low affinity neurotrophin receptor p75NTRlow-affinity nerve growth factor receptorp75 ICD | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P08138 | ||
| Ensembl transtripts involved in fusion gene | ENST00000361786, ENST00000555437, ENST00000555611, | ENST00000172229, ENST00000504201, | |
| Fusion gene scores | * DoF score | 2 X 1 X 3=6 | 4 X 2 X 3=24 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KIAA1737 [Title/Abstract] AND NGFR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NGFR | GO:0007266 | Rho protein signal transduction | 16712417 |
| Tgene | NGFR | GO:1900182 | positive regulation of protein localization to nucleus | 26268439 |
| Tgene | NGFR | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 26268439 |
| Tgene | NGFR | GO:1904646 | cellular response to amyloid-beta | 11927634 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-QT-A5XN-01A | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000361786 | ENST00000172229 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| 5UTR-5UTR | ENST00000361786 | ENST00000504201 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| 5UTR-3CDS | ENST00000555437 | ENST00000172229 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| 5UTR-5UTR | ENST00000555437 | ENST00000504201 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| 5UTR-3CDS | ENST00000555611 | ENST00000172229 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
| 5UTR-5UTR | ENST00000555611 | ENST00000504201 | KIAA1737 | chr14 | 77564704 | + | NGFR | chr17 | 47579425 | + |
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FusionProtFeatures for KIAA1737_NGFR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIAA1737 | NGFR |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Plays a role in the regulation of the translocation ofGLUT4 to the cell surface in adipocytes and skeletal muscle cellsin response to insulin, probably by regulating RAB31 activity, andthereby contributes to the regulation of insulin-dependent glucoseuptake (By similarity). Low affinity receptor which can bind toNGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well ascell death of neural cells. Necessary for the circadianoscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1in the suprachiasmatic nucleus (SCN) of the brain and in liver andof the genes involved in glucose and lipid metabolism in theliver. {ECO:0000250, ECO:0000269|PubMed:14966521,ECO:0000269|PubMed:23785138}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIAA1737_NGFR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIAA1737_NGFR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KIAA1737 | NGFR | PRKACB, NGF, NDN, NDNL2, FSCN1, MAGED1, TRADD, MAGEH1, CAV1, NGFRAP1, TRAF1, TRAF3, TRAF4, TRAF5, TRAF6, TRAF2, SHC1, TRIM37, TCF19, UFD1L, H2AFX, TK1, CDKN1A, SMN1, STMN2, RCC1, RPN2, TTR, ANXA7, NGFR, BFAR, CD80, SQSTM1, IKBKB, NTRK1, MDM2, TP53 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA1737_NGFR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1737_NGFR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NGFR | C0011581 | Depressive disorder | 2 | PSYGENET |
| Tgene | NGFR | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | NGFR | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | NGFR | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | NGFR | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | NGFR | C0036572 | Seizures | 1 | CTD_human |
| Tgene | NGFR | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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