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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18752

FusionGeneSummary for KIAA1731_CCDC67

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1731_CCDC67
Fusion gene ID: 18752
HgeneTgene
Gene symbol

KIAA1731

CCDC67

Gene ID

85459

159989

Gene namecentrosomal protein 295deuterosome assembly protein 1
SynonymsKIAA1731CCDC67
Cytomap

11q21

11q21

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 295 kDacentriolar protein CEP295centrosomal protein 295kDadeuterosome assembly protein 1coiled-coil domain containing 67coiled-coil domain-containing protein 67deuterosome protein 1
Modification date2018051920180523
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000325212, ENST00000344196, 
ENST00000411936, ENST00000531700, 
ENST00000531622, 
ENST00000530053, 
ENST00000530273, ENST00000298050, 
ENST00000527307, ENST00000525646, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: KIAA1731 [Title/Abstract] AND CCDC67 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1731

GO:1902117

positive regulation of organelle assembly

25131205


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-G3-A5SL-01AKIAA1731chr11

93394940

+CCDC67chr11

93104204

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000325212ENST00000530053KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000325212ENST00000530273KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000325212ENST00000298050KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000325212ENST00000527307KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000325212ENST00000525646KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000344196ENST00000530053KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000344196ENST00000530273KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000344196ENST00000298050KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000344196ENST00000527307KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000344196ENST00000525646KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000411936ENST00000530053KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000411936ENST00000530273KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000411936ENST00000298050KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000411936ENST00000527307KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
5UTR-intronENST00000411936ENST00000525646KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531700ENST00000530053KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531700ENST00000530273KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531700ENST00000298050KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531700ENST00000527307KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531700ENST00000525646KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531622ENST00000530053KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531622ENST00000530273KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531622ENST00000298050KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531622ENST00000527307KIAA1731chr11

93394940

+CCDC67chr11

93104204

+
intron-intronENST00000531622ENST00000525646KIAA1731chr11

93394940

+CCDC67chr11

93104204

+

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FusionProtFeatures for KIAA1731_CCDC67


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1731

CCDC67

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1731_CCDC67


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1731_CCDC67


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1731CCDC67CCDC85B, IFIT3, DGCR6, AMPH, ESRRG, GEM, GOLGA2, KIFC3, KRT15, SUMO1, ZNF148, EXOC5, ZNF460, TFPT, TBC1D22B, TRIM54, ING5, BRMS1L, FBF1, DGCR6L, IFT20, ZNF572, CCDC67, TXLNB, TXLNA, GOLGA3, HIP1, DGKH, SPAG5, ANXA13, TRAF7, KNSTRN, TRAF6, MAFF, MAFG, JUN, C17orf70, CEP85, CCHCR1, CCDC57, CEP152, OFD1, CSPP1, PRPF4B, NKTR, CEP128, MPHOSPH9, KIAA1671, TUBG1, PCNT, MAGED1, CEP131, CEP63, CEP192, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1731_CCDC67


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1731_CCDC67


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource