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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18751

FusionGeneSummary for KIAA1683_FKBP8

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1683_FKBP8
Fusion gene ID: 18751
HgeneTgene
Gene symbol

KIAA1683

FKBP8

Gene ID

23770

Gene nameFK506 binding protein 8
SynonymsFKBP38|FKBPr38
Cytomap

19p13.11

Type of geneprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase
Modification date20180522
UniProtAcc

Q14318

Ensembl transtripts involved in fusion geneENST00000600328, ENST00000600359, 
ENST00000392413, 
ENST00000597960, 
ENST00000610101, ENST00000596558, 
ENST00000222308, ENST00000608443, 
ENST00000453489, 
Fusion gene scores* DoF score1 X 1 X 1=111 X 11 X 5=605
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1683 [Title/Abstract] AND FKBP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N7-A4Y8-01AKIAA1683chr19

18375734

-FKBP8chr19

18652805

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000600328ENST00000597960KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600328ENST00000610101KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600328ENST00000596558KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600328ENST00000222308KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600328ENST00000608443KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600328ENST00000453489KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000597960KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000610101KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000596558KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000222308KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000608443KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
5CDS-5UTRENST00000600359ENST00000453489KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000597960KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000610101KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000596558KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000222308KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000608443KIAA1683chr19

18375734

-FKBP8chr19

18652805

-
intron-5UTRENST00000392413ENST00000453489KIAA1683chr19

18375734

-FKBP8chr19

18652805

-

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FusionProtFeatures for KIAA1683_FKBP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1683

FKBP8

Q14318

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1683_FKBP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1683_FKBP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1683PLSCR1, CALML3, CALM2, TRIP6, CALM1, CALM3, TRIM27, SIAH1, MID2, PUF60, LZTS2, RBM17, C17orf104, EFCAB2, AJUBA, KDM5C, HIST2H2AC, AMER1, AHR, ANAPC1, PJA1, KIAA0232, APAF1, JMJD4, APC, SAV1, RNF31, PASK, DIS3L, OTUD4, PEX5, FBLN5, USP54, ANAPC5, TSC22D3, N4BP2L2, ANGEL1, PPP1R9A, WRAP53, CARM1, SEC23IP, TTC38, NME7, STIL, TUBGCP6, DICER1, PRKAR2B, TCF25, CCDC85C, TARSL2, WDR59, PRMT7, TUBA4A, GPRASP2, YTHDF1, HAUS7, PJA2, MCM3AP, PPP6R1FKBP8BCL2, BCL2L1, USP19, BRE, EGFR, HSP90AA1, CALM1, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD6, PSMD7, PSMD11, PSMD12, PSMD13, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB5, PSMB7, ADRM1, PTPRK, UBC, TERF1, EGLN1, CUL3, VHL, ATP13A2, SURF1, MRPL11, YME1L1, UQCRC1, UQCRC2, MRPL15, SSR1, UQCRFS1, PGRMC1, DHODH, NDUFB10, TOMM22, ABCC1, NNT, KCNH2, FKBP8, CAMK2A, CLN3, ADRB2, BNIPL, ARHGEF5, CDK20, PDCL, SUGT1, PTGES3, CACYBP, HSPBP1, RHEB, MTOR, MLST8, RPTOR, RICTOR, CCDC8, RPS6KB2, ABCB7, TCTN2, TCTN3, EVC2, TMEM216, MLH1, XRCC3, VAPA, ATP6AP2, COQ9, TMEM258, CLCN1, CUL4A, CUL4B, MTMR11, PTPMT1, ANKMY2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1683_FKBP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1683_FKBP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource