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Fusion gene ID: 18741 |
FusionGeneSummary for KIAA1671_CRKL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIAA1671_CRKL | Fusion gene ID: 18741 | Hgene | Tgene | Gene symbol | KIAA1671 | CRKL | Gene ID | 85379 | 1399 |
| Gene name | KIAA1671 | CRK like proto-oncogene, adaptor protein | |
| Synonyms | - | - | |
| Cytomap | 22q11.23 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein KIAA1671CTA-221G9.5 | crk-like proteinv-crk avian sarcoma virus CT10 oncogene homolog-like | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BY89 | P46109 | |
| Ensembl transtripts involved in fusion gene | ENST00000406486, ENST00000358431, ENST00000401395, | ENST00000354336, | |
| Fusion gene scores | * DoF score | 14 X 8 X 9=1008 | 3 X 3 X 3=27 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/1008*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KIAA1671 [Title/Abstract] AND CRKL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-A6-5657-01A | KIAA1671 | chr22 | 25425507 | + | CRKL | chr22 | 21303999 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000406486 | ENST00000354336 | KIAA1671 | chr22 | 25425507 | + | CRKL | chr22 | 21303999 | + |
| In-frame | ENST00000358431 | ENST00000354336 | KIAA1671 | chr22 | 25425507 | + | CRKL | chr22 | 21303999 | + |
| intron-3CDS | ENST00000401395 | ENST00000354336 | KIAA1671 | chr22 | 25425507 | + | CRKL | chr22 | 21303999 | + |
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FusionProtFeatures for KIAA1671_CRKL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIAA1671 | CRKL |
| May mediate the transduction of intracellular signals. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CRKL | chr22:25425507 | chr22:21303999 | ENST00000354336 | + | 1 | 3 | 123_183 | 259 | 304 | Domain | SH3 1 |
| Tgene | CRKL | chr22:25425507 | chr22:21303999 | ENST00000354336 | + | 1 | 3 | 14_102 | 259 | 304 | Domain | SH2 |
| Tgene | CRKL | chr22:25425507 | chr22:21303999 | ENST00000354336 | + | 1 | 3 | 235_296 | 259 | 304 | Domain | SH3 2 |
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FusionGeneSequence for KIAA1671_CRKL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KIAA1671_ENST00000406486_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_558aa MATRVEVGSITPLTAVPGLGEMGKEETLTRTYFLQAGEASGAPPARILEAKSPLRSPARLLPLPRLAPKPFSKEQDVKSPVPSLRPSSTG PSPSGGLSEEPAAKDLDNRMPGLVGQEVGSGEGPRTSSPLFNKAVFLRPSSSTMILFETTKSGPALGKAVSEGAEEAKLGVSGSRPEVAA KPALPTQKPAGTLPRSAPLSQDTKPPVPQEEAGQDHPPSKASSVEDTARPLVEPRPRLKRRPVSAIFTESIQPQKPGPGAAATVGKVPPT PPEKTWVRKPRPLSMDLTARFENKEALLRKVADEGSGPTAGDMAGLERPRAASKLDRDCLVKAEAPLHDPDLDFLEVAKKIRERKEKMLS KPEMGSPRALVGGSSGVTPSNDQSPWEEKAKLDPEPEKAAESPSPRLGRGLELAEVKSRVADGEAAAGGEWASRRSVRKCISLFREDSTL ALAVGSESPLATPASPSAAPEPEKGVVSVQERIRGWTAESSEAKPEVRRRTFQARPLSADLTKLLVTSXKSQGXIXMASGKAKXTGAKGF >In-frame_KIAA1671_ENST00000358431_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_558aa MATRVEVGSITPLTAVPGLGEMGKEETLTRTYFLQAGEASGAPPARILEAKSPLRSPARLLPLPRLAPKPFSKEQDVKSPVPSLRPSSTG PSPSGGLSEEPAAKDLDNRMPGLVGQEVGSGEGPRTSSPLFNKAVFLRPSSSTMILFETTKSGPALGKAVSEGAEEAKLGVSGSRPEVAA KPALPTQKPAGTLPRSAPLSQDTKPPVPQEEAGQDHPPSKASSVEDTARPLVEPRPRLKRRPVSAIFTESIQPQKPGPGAAATVGKVPPT PPEKTWVRKPRPLSMDLTARFENKEALLRKVADEGSGPTAGDMAGLERPRAASKLDRDCLVKAEAPLHDPDLDFLEVAKKIRERKEKMLS KPEMGSPRALVGGSSGVTPSNDQSPWEEKAKLDPEPEKAAESPSPRLGRGLELAEVKSRVADGEAAAGGEWASRRSVRKCISLFREDSTL ALAVGSESPLATPASPSAAPEPEKGVVSVQERIRGWTAESSEAKPEVRRRTFQARPLSADLTKLLVTSXKSQGXIXMASGKAKXTGAKGF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KIAA1671_ENST00000406486_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_1676nt ATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAGATGGGCAAGGAGGAGACCCTGACGAGG ACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAGAGCCCCCTGCGGAGCCCGGCCCGGTTA CTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTCCCGTCTCTGCGGCCCAGTTCGACTGGA CCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCCGGCTTGGTGGGGCAGGAGGTGGGCAGT GGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCCAGCACCATGATTCTCTTCGAAACCACC AAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTGTCCGGCTCCCGGCCTGAGGTGGCTGCC AAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAGGACACAAAACCACCTGTACCCCAAGAG GAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTTGTGGAGCCCAGGCCTCGCCTGAAGAGA AGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCGGCCACAGTGGGCAAAGTGCCACCCACC CCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTTGAGAACAAAGAGGCCTTGCTGAGGAAG GTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCAGCGTCCAAGCTGGACAGGGACTGTTTG GTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATCCGTGAACGGAAGGAGAAGATGCTTTCG AAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAATGACCAGAGTCCCTGGGAAGAAAAGGCC AAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTAGAACTTGCTGAGGTTAAGAGCAGAGTG GCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATCAGCCTGTTTCGGGAGGACAGCACCTTG GCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAGCCGGAGAAAGGGGTTGTGAGCGTTCAG GAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACGTTCCAGGCTCGGCCGCTGTCGGCGGAT TTGACCAAATTGTTGGTGACATCGTGAAAGTCACAAGGATGAATATAAATGGCCAGTGGGAAGGCGAAGTGAACGGGCGCAAAGGGCTTT >In-frame_KIAA1671_ENST00000358431_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_1676nt ATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAGATGGGCAAGGAGGAGACCCTGACGAGG ACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAGAGCCCCCTGCGGAGCCCGGCCCGGTTA CTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTCCCGTCTCTGCGGCCCAGTTCGACTGGA CCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCCGGCTTGGTGGGGCAGGAGGTGGGCAGT GGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCCAGCACCATGATTCTCTTCGAAACCACC AAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTGTCCGGCTCCCGGCCTGAGGTGGCTGCC AAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAGGACACAAAACCACCTGTACCCCAAGAG GAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTTGTGGAGCCCAGGCCTCGCCTGAAGAGA AGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCGGCCACAGTGGGCAAAGTGCCACCCACC CCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTTGAGAACAAAGAGGCCTTGCTGAGGAAG GTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCAGCGTCCAAGCTGGACAGGGACTGTTTG GTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATCCGTGAACGGAAGGAGAAGATGCTTTCG AAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAATGACCAGAGTCCCTGGGAAGAAAAGGCC AAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTAGAACTTGCTGAGGTTAAGAGCAGAGTG GCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATCAGCCTGTTTCGGGAGGACAGCACCTTG GCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAGCCGGAGAAAGGGGTTGTGAGCGTTCAG GAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACGTTCCAGGCTCGGCCGCTGTCGGCGGAT TTGACCAAATTGTTGGTGACATCGTGAAAGTCACAAGGATGAATATAAATGGCCAGTGGGAAGGCGAAGTGAACGGGCGCAAAGGGCTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KIAA1671_ENST00000406486_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_5967nt GCGGGCAGGTGGCGGCGCGGCGCGGGCTGGCGGTGGCTCCACGACAGGGTCTTACTCTGTCACCCAGGCTGGCGTGCCATGGTGCAGTCA TAGCTCACTGCAGCCTCAAATTCATGGGCTCAAGCAATTCACCTCAGCCTCCCAAAGTGCTGGAACTACAAGCATACACCACCATACCCA ACCTGCTGAAACTCAGCCTGCTGGGACGAGTCTTCTTTCCCCCTTCTTGTTTCTGCCATGGAAGTGTGTGGACAGCCCCATTCATGATGA CATGTGACACTACTGGCTTTTCCCGGCAGTCACACCCCCTGACCCAGGGCCTGCCAGCTTGGCAATTGCTTCTCCATTCTTGAAGTTCCT AACCCCCATGAATCCACAACCATAACCATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAG ATGGGCAAGGAGGAGACCCTGACGAGGACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAG AGCCCCCTGCGGAGCCCGGCCCGGTTACTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTC CCGTCTCTGCGGCCCAGTTCGACTGGACCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCC GGCTTGGTGGGGCAGGAGGTGGGCAGTGGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCC AGCACCATGATTCTCTTCGAAACCACCAAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTG TCCGGCTCCCGGCCTGAGGTGGCTGCCAAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAG GACACAAAACCACCTGTACCCCAAGAGGAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTT GTGGAGCCCAGGCCTCGCCTGAAGAGAAGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCG GCCACAGTGGGCAAAGTGCCACCCACCCCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTT GAGAACAAAGAGGCCTTGCTGAGGAAGGTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCA GCGTCCAAGCTGGACAGGGACTGTTTGGTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATC CGTGAACGGAAGGAGAAGATGCTTTCGAAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAAT GACCAGAGTCCCTGGGAAGAAAAGGCCAAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTA GAACTTGCTGAGGTTAAGAGCAGAGTGGCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATC AGCCTGTTTCGGGAGGACAGCACCTTGGCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAG CCGGAGAAAGGGGTTGTGAGCGTTCAGGAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACG TTCCAGGCTCGGCCGCTGTCGGCGGATTTGACCAAATTGTTGGTGACATCGTGAAAGTCACAAGGATGAATATAAATGGCCAGTGGGAAG GCGAAGTGAACGGGCGCAAAGGGCTTTTCCCCTTTACGCACGTCAAAATCTTTGACCCTCAAAACCCAGATGAAAACGAGTGATTGCTGT TGCCCTGTTTCCTGCTGCTTTGTTGTTCTGCCTGTCCTAGTCTCCTTTGAAGTGGGAAAGCATTTTCTCTCATAGGCAAGTCACACTGCA TTGCCGAAGTCCAGCTTTCTGCAGACTGGCAGTCGCACACACATTTGGAATGCACACAGCGGCTGCCTCCTGATGTTTGTATCATAGTCG TATTGTCAAAGAGTAGCCGATTTTAGAGTTCTTTTGGATCATAAACTGGAAATACTGATGGAAGCACACAAGTGGAGAGAAGTTGACATG GAAAGGGTCTTCCTTCTCATTGCTGCCCGTTTGTACATGGGACTGATTCTGTTGTGTTCACCAGAGAAAGCTTGAGGCCATGGCGAGATA CTGCATGTTTGCTGTTCCACAAAGCAGTGGCTTAGCTGCCATCTTGCTTTTCTTTGGACAACAGGAAGTGAACCTTAAGGAAGAGAGAAT TCTGTTCTAAAACTCCAAAATCTGGCTTTTTTTTTTCTTTTGTTTTGGTTTGGTTTTGGAAAACTAATTAATTAGACTTGTGTGGGGGTT TTTTTTTGTTTTGTTTTGTTTGTTTTGTTTTGTTTTTTTGAGACGGTGTCTCGCTGCATCACCCAGGCTGGAGTGCAGTGGCGCAATCTC GCCTTCCTGCAGTCTCCGCCTCCTGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCGCGCACACCACGCC CAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGACCAGGCTGGTCTCAAACTCCTGACTTCAGGTGATCCACCCGCC TTCAGCCTCCCAACGTGCTGGGATTACAGCCGTGAGCCGCCGCGCCTGGCCTAGACTTGTGTGTTCTAAACAGGTTAAGTAGCAGGTTGG GTTTTTATGATAGTGCAAGGAATGACTCATGCCTCTGAGCTTCTAAACTGAAGCTGCTGTAACTAAAGGAATCTGAAAAGAACAACCCTG AAGCAGAGGCCTTTATTGTCTTGGTTGCCAGTAGTACCTTGTTTTGCCATGTAGCAGACAACACACAAAATAATGCAGTTGTGGTGTGCC ATGCTATGTGCACAGCCCCTTGGATTACTTTGTTTTAAAAAGCATCAGAGTTGGGGGTACTTTAGGGAAACCTTTGCTTACCTTGTTTTG CCAGTGATAAGAGCAGTGGGTTGGAGGGCACTTGGCCAGTTTTCTGTTCAGCTTTTCAGTGAATGTACCCCTTTAAGGTTCAGACTTAAA CTTCCTTAAAAAGTGGCGTTGTTCATAGAATCGTTGGACTCATTAATGAATCGTTCAACTCCACTCACTGAAGCCCAGACCTCCGTGCCC AGGCCCAATCTCGTCAGGCTGCCAGAGAAAGTTGGTGCTGCTCATACTGGTCTCACAGTCTAAGTAAGTGTCTGTGATGCTCCCAAGCAA AGGAAATGCAAGCTCTGGAAATTCGTTAATGTATTTGATGTCTTAGTGTTTTAGTGACTAGGGAGACCATTAACTAGTTTATCATTAACC ACTTATCAGTGTATTGATGTTAAAGCATTTCCCTGTTAGCTAAAAGAGGCCTGTTCATACAAGCCAACTGGTATATACGTGTGGTTCATC CATCATCTGCTGCACATAGCAGACTAGAATTCTGGGAACCCTGTGCAATTCAGTCTGCTCTCCCTTGTGGACCCTGGTAAAGAAAAGCCT CAGCTCATAGTGAACACAGCAGACCTAGAAATGTAGCAGCAGCCTACTGAGTAGCTTTCATTTACTGATCATCTGCTGTGACTGTGGCCC TGTCTGGAGGTTCCTAGGTTTTGAGATTTAGAGCAATGCATTCTGGAGACAGAACCAGCAGAACAGCCATTTTTCAATTTTTCTTTAAAT CAGTATTCCATCAGGCAGATAACTGCTGTATTCATGAATCTTGAGAGTGTTCCTGAGACAGAATTAATGGTCATTTGGGAAAACTATCGC CATGGCTTCCCATCTGTGGTTTTCCTCTAAAAGCCTTGGAGATTAGCCCTTCCTTGCCAGTGAGAACGGTGACCGCCTCCTGCTCTGCAC GGTCTGCGGCAGTTGCCGCTTCTGGTTAGGTGTGTCAGGTTGGCTTATTTTGGGTTCAGGCCTGGCGTAGCACCCACAAGTGGCAGACAT ATCACAAGAGTCCCCAGACTCTGCCTAGAAACAGTGTTTGCCCTTTGGCCAGTGACGTGGTTCATCCCGGCCCATGTTGAGCCATGAGTG GAGTTTCCAACAGAGGGAGGAATGTGTGCCTTGTTCAAGGAGGGCACGACCCTTAGGCCTTTTTCAACCAGATTTAGCTGAAGGGCTTGA CACCTTTGAATTACAGCAGTTGACTCAGAGTGCAAGAAGTCTGGCCATTTTGGAAAGCAAGGTTTCCTTTCAGCCCTGTCTACTGACCAA TACCCCGACTCACCTTGTGTGGCGCACTTCAGAATCAGATATACCTAGAGTATACCTGTGGTTTGGTTTTATAATTAATCAGCTCGTTAC TTCAGCCCATGAAAATGGCATCCAGGGCTGCCAGGAGATTCAGAGCTCAAAACAAGGCGAGCTTGAGTTCTGCACTCCAGATATGTGCCA AAACTAGTAAAACTTAACGGACTTACAACCTTGTCAGTTTTTTTAATGAGGCAGGGATACTCTGTTTTTCACACTAAACATATGAATGCA GCACTGCTGCCTCAGCTCAGCTTCGTGCCTGGGTTCCCCACTGGTCTGGGAAGACTGTTGTGCTCCATAGAGCAGTGCACATCTGACCCA GAGGGTGGGTGTTCATAACTGCTACTTGCTCTGCTCTACCATGTTTAAAGAAATATTTGGATGTTAAATTAACTCACTATGGTTTTTCAC CTGGGAAGGAAACAAATTACGTACTAGAGGGCATTGACTGGTTAAAAACTTGTGTATCCCGGGAAGGACCTGCGGTACAGGAGTCAGCCA TGTCTGTGCTGTGTGGAACCACCTGATGACATGGTTAACGAGGAAGACGATGTGTTGACCGGCTGCCGTTTGAGGACTTTGGTCACCCAG ACTAGACACCTTCTGTGCTCATGTTTGGAAAGCTGAAAGGGAAGGACAGCTGTGCCCTCCTGGGAGCTCATGTGTCCCTGGCGCTGTGCT AGCTTTCCTTTACAGCTGTTTACAGACAAGGCAGGCCTGAGGCAGATGGCCACTGCTCTTGTGATGTTTGCTCAGAGGAATATGAACATT TTATTTTTGAAAAGGGATGATGTGGTTTTTTGCCAGGTGTTTATAATTAATCCTTTAATATTATGGTTATTAACCTCTTAAACATGAATG AATTCTTGATTGTTTTAACACAGTACCTAAGACTAATGCTTTCTGTGGACACCACTGAGCTCTGCCTCAACTCCACCCTCTGCGACCGGA GGACTATGCCCCTAGTAACTGCTGTCGGTGTGGACGCTGTGCTGGTTCTGTTTTCTAAAGGAGCAGAAGGACAGGTCTCTGAGACAGGAT CGTTGTCCCTACAGGAGGAACAGTGGCCTTGCTTCTTAGACGGTCTTCACTGTGTGTTTTAAAACAACAACAACAACAACAACAACAACA TAAAACTCTTTTGACCTGTAACTTAAAGATCATAAACTTCAGGCAATAATATTTTCTGTGTAAGCTTTTAAAATTATTTTTGGGGATCAT AGCTTGTTTTATTTTGTGCTATAAAATTAACAGTATTAAATGACTTATATTCTTAGAATACATCGAGTGTCTTTTCTTAACAGATTAGTG CCTTTTTATTTTTGTATTCCGTTTTACGTTACTGGTCCCAGCATCAAAACCCTTGTTTCCATGGCCTGTTTGTATATTGTCTCAATAAAA >In-frame_KIAA1671_ENST00000358431_chr22_25425507_+_CRKL_ENST00000354336_chr22_21303999_+_5606nt ACCCCCATGAATCCACAACCATAACCATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAGA TGGGCAAGGAGGAGACCCTGACGAGGACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAGA GCCCCCTGCGGAGCCCGGCCCGGTTACTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTCC CGTCTCTGCGGCCCAGTTCGACTGGACCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCCG GCTTGGTGGGGCAGGAGGTGGGCAGTGGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCCA GCACCATGATTCTCTTCGAAACCACCAAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTGT CCGGCTCCCGGCCTGAGGTGGCTGCCAAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAGG ACACAAAACCACCTGTACCCCAAGAGGAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTTG TGGAGCCCAGGCCTCGCCTGAAGAGAAGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCGG CCACAGTGGGCAAAGTGCCACCCACCCCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTTG AGAACAAAGAGGCCTTGCTGAGGAAGGTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCAG CGTCCAAGCTGGACAGGGACTGTTTGGTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATCC GTGAACGGAAGGAGAAGATGCTTTCGAAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAATG ACCAGAGTCCCTGGGAAGAAAAGGCCAAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTAG AACTTGCTGAGGTTAAGAGCAGAGTGGCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATCA GCCTGTTTCGGGAGGACAGCACCTTGGCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAGC CGGAGAAAGGGGTTGTGAGCGTTCAGGAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACGT TCCAGGCTCGGCCGCTGTCGGCGGATTTGACCAAATTGTTGGTGACATCGTGAAAGTCACAAGGATGAATATAAATGGCCAGTGGGAAGG CGAAGTGAACGGGCGCAAAGGGCTTTTCCCCTTTACGCACGTCAAAATCTTTGACCCTCAAAACCCAGATGAAAACGAGTGATTGCTGTT GCCCTGTTTCCTGCTGCTTTGTTGTTCTGCCTGTCCTAGTCTCCTTTGAAGTGGGAAAGCATTTTCTCTCATAGGCAAGTCACACTGCAT TGCCGAAGTCCAGCTTTCTGCAGACTGGCAGTCGCACACACATTTGGAATGCACACAGCGGCTGCCTCCTGATGTTTGTATCATAGTCGT ATTGTCAAAGAGTAGCCGATTTTAGAGTTCTTTTGGATCATAAACTGGAAATACTGATGGAAGCACACAAGTGGAGAGAAGTTGACATGG AAAGGGTCTTCCTTCTCATTGCTGCCCGTTTGTACATGGGACTGATTCTGTTGTGTTCACCAGAGAAAGCTTGAGGCCATGGCGAGATAC TGCATGTTTGCTGTTCCACAAAGCAGTGGCTTAGCTGCCATCTTGCTTTTCTTTGGACAACAGGAAGTGAACCTTAAGGAAGAGAGAATT CTGTTCTAAAACTCCAAAATCTGGCTTTTTTTTTTCTTTTGTTTTGGTTTGGTTTTGGAAAACTAATTAATTAGACTTGTGTGGGGGTTT TTTTTTGTTTTGTTTTGTTTGTTTTGTTTTGTTTTTTTGAGACGGTGTCTCGCTGCATCACCCAGGCTGGAGTGCAGTGGCGCAATCTCG CCTTCCTGCAGTCTCCGCCTCCTGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCGCGCACACCACGCCC AGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGACCAGGCTGGTCTCAAACTCCTGACTTCAGGTGATCCACCCGCCT TCAGCCTCCCAACGTGCTGGGATTACAGCCGTGAGCCGCCGCGCCTGGCCTAGACTTGTGTGTTCTAAACAGGTTAAGTAGCAGGTTGGG TTTTTATGATAGTGCAAGGAATGACTCATGCCTCTGAGCTTCTAAACTGAAGCTGCTGTAACTAAAGGAATCTGAAAAGAACAACCCTGA AGCAGAGGCCTTTATTGTCTTGGTTGCCAGTAGTACCTTGTTTTGCCATGTAGCAGACAACACACAAAATAATGCAGTTGTGGTGTGCCA TGCTATGTGCACAGCCCCTTGGATTACTTTGTTTTAAAAAGCATCAGAGTTGGGGGTACTTTAGGGAAACCTTTGCTTACCTTGTTTTGC CAGTGATAAGAGCAGTGGGTTGGAGGGCACTTGGCCAGTTTTCTGTTCAGCTTTTCAGTGAATGTACCCCTTTAAGGTTCAGACTTAAAC TTCCTTAAAAAGTGGCGTTGTTCATAGAATCGTTGGACTCATTAATGAATCGTTCAACTCCACTCACTGAAGCCCAGACCTCCGTGCCCA GGCCCAATCTCGTCAGGCTGCCAGAGAAAGTTGGTGCTGCTCATACTGGTCTCACAGTCTAAGTAAGTGTCTGTGATGCTCCCAAGCAAA GGAAATGCAAGCTCTGGAAATTCGTTAATGTATTTGATGTCTTAGTGTTTTAGTGACTAGGGAGACCATTAACTAGTTTATCATTAACCA CTTATCAGTGTATTGATGTTAAAGCATTTCCCTGTTAGCTAAAAGAGGCCTGTTCATACAAGCCAACTGGTATATACGTGTGGTTCATCC ATCATCTGCTGCACATAGCAGACTAGAATTCTGGGAACCCTGTGCAATTCAGTCTGCTCTCCCTTGTGGACCCTGGTAAAGAAAAGCCTC AGCTCATAGTGAACACAGCAGACCTAGAAATGTAGCAGCAGCCTACTGAGTAGCTTTCATTTACTGATCATCTGCTGTGACTGTGGCCCT GTCTGGAGGTTCCTAGGTTTTGAGATTTAGAGCAATGCATTCTGGAGACAGAACCAGCAGAACAGCCATTTTTCAATTTTTCTTTAAATC AGTATTCCATCAGGCAGATAACTGCTGTATTCATGAATCTTGAGAGTGTTCCTGAGACAGAATTAATGGTCATTTGGGAAAACTATCGCC ATGGCTTCCCATCTGTGGTTTTCCTCTAAAAGCCTTGGAGATTAGCCCTTCCTTGCCAGTGAGAACGGTGACCGCCTCCTGCTCTGCACG GTCTGCGGCAGTTGCCGCTTCTGGTTAGGTGTGTCAGGTTGGCTTATTTTGGGTTCAGGCCTGGCGTAGCACCCACAAGTGGCAGACATA TCACAAGAGTCCCCAGACTCTGCCTAGAAACAGTGTTTGCCCTTTGGCCAGTGACGTGGTTCATCCCGGCCCATGTTGAGCCATGAGTGG AGTTTCCAACAGAGGGAGGAATGTGTGCCTTGTTCAAGGAGGGCACGACCCTTAGGCCTTTTTCAACCAGATTTAGCTGAAGGGCTTGAC ACCTTTGAATTACAGCAGTTGACTCAGAGTGCAAGAAGTCTGGCCATTTTGGAAAGCAAGGTTTCCTTTCAGCCCTGTCTACTGACCAAT ACCCCGACTCACCTTGTGTGGCGCACTTCAGAATCAGATATACCTAGAGTATACCTGTGGTTTGGTTTTATAATTAATCAGCTCGTTACT TCAGCCCATGAAAATGGCATCCAGGGCTGCCAGGAGATTCAGAGCTCAAAACAAGGCGAGCTTGAGTTCTGCACTCCAGATATGTGCCAA AACTAGTAAAACTTAACGGACTTACAACCTTGTCAGTTTTTTTAATGAGGCAGGGATACTCTGTTTTTCACACTAAACATATGAATGCAG CACTGCTGCCTCAGCTCAGCTTCGTGCCTGGGTTCCCCACTGGTCTGGGAAGACTGTTGTGCTCCATAGAGCAGTGCACATCTGACCCAG AGGGTGGGTGTTCATAACTGCTACTTGCTCTGCTCTACCATGTTTAAAGAAATATTTGGATGTTAAATTAACTCACTATGGTTTTTCACC TGGGAAGGAAACAAATTACGTACTAGAGGGCATTGACTGGTTAAAAACTTGTGTATCCCGGGAAGGACCTGCGGTACAGGAGTCAGCCAT GTCTGTGCTGTGTGGAACCACCTGATGACATGGTTAACGAGGAAGACGATGTGTTGACCGGCTGCCGTTTGAGGACTTTGGTCACCCAGA CTAGACACCTTCTGTGCTCATGTTTGGAAAGCTGAAAGGGAAGGACAGCTGTGCCCTCCTGGGAGCTCATGTGTCCCTGGCGCTGTGCTA GCTTTCCTTTACAGCTGTTTACAGACAAGGCAGGCCTGAGGCAGATGGCCACTGCTCTTGTGATGTTTGCTCAGAGGAATATGAACATTT TATTTTTGAAAAGGGATGATGTGGTTTTTTGCCAGGTGTTTATAATTAATCCTTTAATATTATGGTTATTAACCTCTTAAACATGAATGA ATTCTTGATTGTTTTAACACAGTACCTAAGACTAATGCTTTCTGTGGACACCACTGAGCTCTGCCTCAACTCCACCCTCTGCGACCGGAG GACTATGCCCCTAGTAACTGCTGTCGGTGTGGACGCTGTGCTGGTTCTGTTTTCTAAAGGAGCAGAAGGACAGGTCTCTGAGACAGGATC GTTGTCCCTACAGGAGGAACAGTGGCCTTGCTTCTTAGACGGTCTTCACTGTGTGTTTTAAAACAACAACAACAACAACAACAACAACAT AAAACTCTTTTGACCTGTAACTTAAAGATCATAAACTTCAGGCAATAATATTTTCTGTGTAAGCTTTTAAAATTATTTTTGGGGATCATA GCTTGTTTTATTTTGTGCTATAAAATTAACAGTATTAAATGACTTATATTCTTAGAATACATCGAGTGTCTTTTCTTAACAGATTAGTGC CTTTTTATTTTTGTATTCCGTTTTACGTTACTGGTCCCAGCATCAAAACCCTTGTTTCCATGGCCTGTTTGTATATTGTCTCAATAAAAC 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FusionGenePPI for KIAA1671_CRKL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KIAA1671 | LATS2, STRN3, TJP2, YWHAB, CCDC8, LUZP4, WDR83, CAPZA2, SDF4, NEU2, PLK4, CEP192, CCDC67, CENPJ, SSX2IP, OFD1, CEP104, CEP162, CEP120, CEP152, CNTROB, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, POC5, DYNLT1, SASS6, RPGRIP1, PPP1CB, FBXL17, CDH1, SSH1, P4HA2, IL17RA, C6orf141, ASB3, PM20D2, NCAPH2, SKP2, F9, DCAF7, KIAA0430, HELZ, NISCH, SOWAHA, PAN2, EIF4ENIF1, PCGF5 | CRKL | BCR, BCAR1, PXN, CBL, ETV6, ABL1, MAP4K1, RAPGEF1, NEDD9, FCGR1A, DOK1, KIT, TYK2, STAT5A, SYK, WAS, PDGFRA, BLNK, ARHGAP32, CD34, IRS4, GRB2, MAP4K5, PIK3R2, PIK3R1, SHC1, PTPN11, EPOR, INPP5D, GAB2, DOCK2, GAB1, CBLB, USP7, PTEN, MSL1, PLEKHA1, MEGF6, LTBP4, GRN, PLSCR1, LAMA5, NOTCH2, ELAVL1, EPS15, EGFR, ERBB2, ERBB3, LMNA, BAG3, WAC, AOX1, BIK, PHC2, RPL31, YY1, ARHGEF5, PPFIBP2, KHDRBS1, TENC1, POLR1D, GAREM, SHANK3, HUWE1, MOV10, NXF1, CUL7, CLIC4, OGT, SEPHS1, HIP1R, HNRNPH2, PDCD6, NTRK1, AREL1, SOCS1, TMEM168, DOK2, RIN3, CEP170, NINL, ODF2, APOB, DDX6, DOCK1, SOS1, MPZL1, KIAA0430, TELO2, TRAP1, PNRC1, EDC4, IMPACT, DCP1A, UBL5, ELMO2, PEAK1, DOCK5, EDC3, PRR3, GORAB, SGK223, DCP2, C15orf54, IGF1R, CRY2, MCM2, OTUB1, CDH1, IFIT5, PTPN4, TNK2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA1671_CRKL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1671_CRKL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CRKL | C0012236 | DiGeorge Syndrome | 1 | CTD_human |
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