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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18722

FusionGeneSummary for KIAA1549L_WARS2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1549L_WARS2
Fusion gene ID: 18722
HgeneTgene
Gene symbol

KIAA1549L

WARS2

Gene ID

25758

10352

Gene nameKIAA1549 liketryptophanyl tRNA synthetase 2, mitochondrial
SynonymsC11orf41|C11orf69|G2NEMMLAS|TrpRS
Cytomap

11p13

1p12

Type of geneprotein-codingprotein-coding
DescriptionUPF0606 protein KIAA1549LUPF0606 protein C11orf41Uncharacterized protein C11orf69tryptophan--tRNA ligase, mitochondrial(Mt)TrpRStryptophan tRNA ligase 2, mitochondrial
Modification date2018051920180523
UniProtAcc

Q6ZVL6

Q9UGM6

Ensembl transtripts involved in fusion geneENST00000321505, ENST00000389726, 
ENST00000265654, 
ENST00000369426, 
ENST00000235521, ENST00000537870, 
ENST00000497761, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 2 X 4=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA1549L [Title/Abstract] AND WARS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CV-6937-01AKIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000321505ENST00000369426KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
Frame-shiftENST00000321505ENST00000235521KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-5UTRENST00000321505ENST00000537870KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-intronENST00000321505ENST00000497761KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
Frame-shiftENST00000389726ENST00000369426KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
Frame-shiftENST00000389726ENST00000235521KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-5UTRENST00000389726ENST00000537870KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-intronENST00000389726ENST00000497761KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
Frame-shiftENST00000265654ENST00000369426KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
Frame-shiftENST00000265654ENST00000235521KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-5UTRENST00000265654ENST00000537870KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-
5CDS-intronENST00000265654ENST00000497761KIAA1549Lchr11

33596419

+WARS2chr1

119619230

-

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FusionProtFeatures for KIAA1549L_WARS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1549L

Q6ZVL6

WARS2

Q9UGM6

Mitochondrial aminoacyl-tRNA synthetase that activateand transfer the amino acids to their corresponding tRNAs duringthe translation of mitochondrial genes and protein synthesis.{ECO:0000305|PubMed:28650581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1549L_WARS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1549L_WARS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1549LGRB2, ATXN1WARS2APP, RMND5A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1549L_WARS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneWARS2Q9UGM6DB00150L-TryptophanTryptophan--tRNA ligase, mitochondrialsmall moleculeapproved|nutraceutical|withdrawn

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RelatedDiseases for KIAA1549L_WARS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource