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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1872

FusionGeneSummary for ANKRD52_PGS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD52_PGS1
Fusion gene ID: 1872
HgeneTgene
Gene symbol

ANKRD52

PGS1

Gene ID

283373

9489

Gene nameankyrin repeat domain 52phosphatidylglycerophosphate synthase 1
SynonymsANKRD33-
Cytomap

12q13.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit CCVWG5837PP6-ARS-Cankyrin repeat domain 33ankyrin repeat domain-containing protein 52protein phosphatase 6 ankyrin repeat subunit Cserine/threonine-protein phosphatase 6 regulaCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1
Modification date2018051920180519
UniProtAcc

Q8NB46

Q32NB8

Ensembl transtripts involved in fusion geneENST00000548241, ENST00000267116, 
ENST00000262764, ENST00000329897, 
ENST00000588281, 
Fusion gene scores* DoF score9 X 8 X 4=2884 X 3 X 3=36
# samples 84
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD52 [Title/Abstract] AND PGS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AM-01AANKRD52chr12

56645799

-PGS1chr17

76411033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000548241ENST00000262764ANKRD52chr12

56645799

-PGS1chr17

76411033

+
intron-3CDSENST00000548241ENST00000329897ANKRD52chr12

56645799

-PGS1chr17

76411033

+
intron-3UTRENST00000548241ENST00000588281ANKRD52chr12

56645799

-PGS1chr17

76411033

+
Frame-shiftENST00000267116ENST00000262764ANKRD52chr12

56645799

-PGS1chr17

76411033

+
Frame-shiftENST00000267116ENST00000329897ANKRD52chr12

56645799

-PGS1chr17

76411033

+
5CDS-3UTRENST00000267116ENST00000588281ANKRD52chr12

56645799

-PGS1chr17

76411033

+

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FusionProtFeatures for ANKRD52_PGS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD52

Q8NB46

PGS1

Q32NB8

Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. Functions in the biosynthesis of the anionicphospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD52_PGS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD52_PGS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD52USP36, USP49, PLK1, PPP6C, SIRT7, MOB1A, MOB1B, PPP6R1, PPP6R2, PPP6R3, MOV10, NXF1, AP2M1, DCLRE1C, CEP44, XPO1, FOXK1, FOXK2, HIF1AN, ZNF785, USP10, TRMT2A, ZNF263, ZNF414, CPNE5, ZNF669, FAM19A3, ZNF223, FOXD4, KIF2B, CAMK4, TRIM25PGS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD52_PGS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD52_PGS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource