FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18705

FusionGeneSummary for KIAA1432_KDM4C

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1432_KDM4C
Fusion gene ID: 18705
HgeneTgene
Gene symbol

KIAA1432

KDM4C

Gene ID

57589

23081

Gene nameRIC1 homolog, RAB6A GEF complex partner 1lysine demethylase 4C
SynonymsCIP150|KIAA1432|bA207C16.1GASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

9p24.1

9p24.1

Type of geneprotein-codingprotein-coding
DescriptionRAB6A-GEF complex partner protein 1RAB6A GEF complex partner 1connexin 43-interacting protein 150 kDaconnexin-43-interacting protein of 150 kDaprotein RIC1 homologlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2018052320180523
UniProtAcc

Q9H3R0

Ensembl transtripts involved in fusion geneENST00000251879, ENST00000414202, 
ENST00000381532, ENST00000418622, 
ENST00000449720, 
ENST00000535193, 
ENST00000543771, ENST00000381306, 
ENST00000381309, ENST00000442236, 
ENST00000489243, ENST00000536108, 
ENST00000428870, ENST00000401787, 
Fusion gene scores* DoF score8 X 5 X 6=2405 X 4 X 4=80
# samples 75
** MAII scorelog2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1432 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1432

GO:0043547

positive regulation of GTPase activity

23091056

TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2E-01AKIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000251879ENST00000535193KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000543771KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000381306KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000381309KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000442236KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000489243KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000251879ENST00000536108KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000251879ENST00000428870KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000251879ENST00000401787KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000535193KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000543771KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000381306KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000381309KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000442236KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000489243KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000414202ENST00000536108KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000414202ENST00000428870KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000414202ENST00000401787KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000535193KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000543771KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000381306KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000381309KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000442236KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000489243KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000381532ENST00000536108KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000381532ENST00000428870KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000381532ENST00000401787KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000535193KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000543771KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000381306KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000381309KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000442236KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000489243KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000418622ENST00000536108KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000418622ENST00000428870KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000418622ENST00000401787KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000535193KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000543771KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000381306KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000381309KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000442236KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000489243KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000449720ENST00000536108KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-3UTRENST00000449720ENST00000428870KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+
5CDS-intronENST00000449720ENST00000401787KIAA1432chr9

5656690

+KDM4Cchr9

7128066

+

Top

FusionProtFeatures for KIAA1432_KDM4C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1432

KDM4C

Q9H3R0

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIAA1432_KDM4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIAA1432_KDM4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1432KDM4CKDM4A, KDM4C, HIST1H3A, H3F3A, PPARG, HDAC1, HDAC3, HIST2H3C, SHMT2, MOV10, NXF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIAA1432_KDM4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIAA1432_KDM4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKDM4CC0025149Medulloblastoma1CTD_human
TgeneKDM4CC0236663Alcohol withdrawal syndrome1PSYGENET