FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18633

FusionGeneSummary for KIAA0922_MND1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0922_MND1
Fusion gene ID: 18633
HgeneTgene
Gene symbol

KIAA0922

MND1

Gene ID

84057

Gene namemeiotic nuclear divisions 1
SynonymsGAJ
Cytomap

4q31.3

Type of geneprotein-coding
Descriptionmeiotic nuclear division protein 1 homologhomolog of yeast MND1meiotic nuclear divisions 1 homolog
Modification date20180523
UniProtAcc

Q9BWT6

Ensembl transtripts involved in fusion geneENST00000440693, ENST00000409663, 
ENST00000409959, 
ENST00000240488, 
ENST00000503967, ENST00000504860, 
Fusion gene scores* DoF score5 X 5 X 5=1251 X 2 X 2=4
# samples 62
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: KIAA0922 [Title/Abstract] AND MND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A12K-01AKIAA0922chr4

154525582

+MND1chr4

154315414

+
TCGARVUCECTCGA-FI-A3PX-01AKIAA0922chr4

154395040

+MND1chr4

154271216

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000440693ENST00000240488KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000440693ENST00000503967KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000440693ENST00000504860KIAA0922chr4

154525582

+MND1chr4

154315414

+
Frame-shiftENST00000409663ENST00000240488KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000409663ENST00000503967KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000409663ENST00000504860KIAA0922chr4

154525582

+MND1chr4

154315414

+
Frame-shiftENST00000409959ENST00000240488KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000409959ENST00000503967KIAA0922chr4

154525582

+MND1chr4

154315414

+
5CDS-intronENST00000409959ENST00000504860KIAA0922chr4

154525582

+MND1chr4

154315414

+
Frame-shiftENST00000440693ENST00000240488KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000440693ENST00000503967KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000440693ENST00000504860KIAA0922chr4

154395040

+MND1chr4

154271216

+
Frame-shiftENST00000409663ENST00000240488KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000409663ENST00000503967KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000409663ENST00000504860KIAA0922chr4

154395040

+MND1chr4

154271216

+
Frame-shiftENST00000409959ENST00000240488KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000409959ENST00000503967KIAA0922chr4

154395040

+MND1chr4

154271216

+
5CDS-3UTRENST00000409959ENST00000504860KIAA0922chr4

154395040

+MND1chr4

154271216

+

Top

FusionProtFeatures for KIAA0922_MND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0922

MND1

Q9BWT6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Required for proper homologous chromosome pairing andefficient cross-over and intragenic recombination during meiosis(By similarity). Stimulates both DMC1- and RAD51-mediatedhomologous strand assimilation, which is required for theresolution of meiotic double-strand breaks.{ECO:0000250|UniProtKB:Q8K396, ECO:0000269|PubMed:16407260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIAA0922_MND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIAA0922_MND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA0922FBXO6, HLA-DRA, ATP1B3, MCOLN3, CGRRF1, BTNL8, CHRNA9, KIF11, PTAR1, FAM46A, NLGN3MND1APP, PSMC3IP, IK, MTERF4, NSUN4, ALOX5, SPAG9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIAA0922_MND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIAA0922_MND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource