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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18614

FusionGeneSummary for KIAA0586_MPP5

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0586_MPP5
Fusion gene ID: 18614
HgeneTgene
Gene symbol

KIAA0586

MPP5

Gene ID

9786

64398

Gene nameKIAA0586membrane palmitoylated protein 5
SynonymsJBTS23|SRTD14|Talpid3PALS1
Cytomap

14q23.1

14q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein TALPID3MAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardust
Modification date2018052320180519
UniProtAcc

Q9BVV6

Q8N3R9

Ensembl transtripts involved in fusion geneENST00000354386, ENST00000556134, 
ENST00000423743, ENST00000261244, 
ENST00000538571, 
ENST00000261681, 
ENST00000555925, ENST00000554911, 
ENST00000556345, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 4=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA0586 [Title/Abstract] AND MPP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-02-0033-01AKIAA0586chr14

58910893

+MPP5chr14

67799497

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000354386ENST00000261681KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000354386ENST00000555925KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000354386ENST00000554911KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000354386ENST00000556345KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000556134ENST00000261681KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000556134ENST00000555925KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000556134ENST00000554911KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000556134ENST00000556345KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000423743ENST00000261681KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000423743ENST00000555925KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000423743ENST00000554911KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000423743ENST00000556345KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000261244ENST00000261681KIAA0586chr14

58910893

+MPP5chr14

67799497

+
Frame-shitENST00000261244ENST00000555925KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000261244ENST00000554911KIAA0586chr14

58910893

+MPP5chr14

67799497

+
5CDS-intronENST00000261244ENST00000556345KIAA0586chr14

58910893

+MPP5chr14

67799497

+
3UTR-3CDSENST00000538571ENST00000261681KIAA0586chr14

58910893

+MPP5chr14

67799497

+
3UTR-3CDSENST00000538571ENST00000555925KIAA0586chr14

58910893

+MPP5chr14

67799497

+
3UTR-intronENST00000538571ENST00000554911KIAA0586chr14

58910893

+MPP5chr14

67799497

+
3UTR-intronENST00000538571ENST00000556345KIAA0586chr14

58910893

+MPP5chr14

67799497

+

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FusionProtFeatures for KIAA0586_MPP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0586

Q9BVV6

MPP5

Q8N3R9

Required for ciliogenesis and sonic hedgehog/SHHsignaling. Required for the centrosomal recruitment of RAB8A andfor the targeting of centriole satellite proteins to centrosomessuch as of PCM1. May play a role in early ciliogenesis in thedisappearance of centriolar satellites that preceeds ciliaryvesicle formation (PubMed:24421332). Involved in regulation ofcell intracellular organization. Involved in regulation of cellpolarity (By similarity). Required for asymmetrical localizationof CEP120 to daughter centrioles (By similarity).{ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9,ECO:0000269|PubMed:24421332}. May play a role in tight junctions biogenesis and in theestablishment of cell polarity in epithelial cells. May modulateSC6A1/GAT1-mediated GABA uptake by stabilizing the transporter.Required for localization of EZR to the apical membrane ofparietal cells and may play a role in the dynamic remodeling ofthe apical cytoskeleton (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0586_MPP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0586_MPP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA0586UBC, HECW2, CENPJ, KIAA0753, CEP120, DYNLT1, TSC22D2, CDC16, C6orf141, NCAPH2, IL17RAMPP5INADL, PARD6A, AMOT, ARHGAP17, LIN7A, ZNF451, AMOTL2, LATS1, LATS2, YAP1, WWOX, LIN7C, AMOTL1, MPDZ, SOCS4, CEP128, NINL, RPH3A, LIN7B, HOMER3, ALOX5, PCDHAC2, RNF19B, SH3KBP1, GAK, STXBP4, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0586_MPP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0586_MPP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIAA0586C0152427Polydactyly1CTD_human
HgeneKIAA0586C0376634Craniofacial Abnormalities1CTD_human
HgeneKIAA0586C4084822JOUBERT SYNDROME 231UNIPROT