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Fusion gene ID: 18613 |
FusionGeneSummary for KIAA0556_NECAB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIAA0556_NECAB2 | Fusion gene ID: 18613 | Hgene | Tgene | Gene symbol | KIAA0556 | NECAB2 | Gene ID | 23247 | 54550 |
| Gene name | KIAA0556 | N-terminal EF-hand calcium binding protein 2 | |
| Synonyms | JBTS26 | EFCBP2|stip-2 | |
| Cytomap | 16p12.1 | 16q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein KIAA0556Katanin-interacting proteinKatnip | N-terminal EF-hand calcium-binding protein 2EF-hand calcium-binding protein 2neuronal calcium binding 2neuronal calcium-binding protein 2synaptotagmin-interacting protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O60303 | Q7Z6G3 | |
| Ensembl transtripts involved in fusion gene | ENST00000261588, ENST00000567894, | ENST00000305202, ENST00000565691, ENST00000567703, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KIAA0556 [Title/Abstract] AND NECAB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NECAB2 | GO:0060168 | positive regulation of adenosine receptor signaling pathway | 17689978 |
| Tgene | NECAB2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 19694902 |
| Tgene | NECAB2 | GO:1900451 | positive regulation of glutamate receptor signaling pathway | 19694902 |
| Tgene | NECAB2 | GO:1904021 | negative regulation of G-protein coupled receptor internalization | 17689978 |
| Tgene | NECAB2 | GO:1905477 | positive regulation of protein localization to membrane | 19694902 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A1N8-01A | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261588 | ENST00000305202 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| 5CDS-5UTR | ENST00000261588 | ENST00000565691 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| 5CDS-intron | ENST00000261588 | ENST00000567703 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| intron-3CDS | ENST00000567894 | ENST00000305202 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| intron-5UTR | ENST00000567894 | ENST00000565691 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
| intron-intron | ENST00000567894 | ENST00000567703 | KIAA0556 | chr16 | 27585277 | + | NECAB2 | chr16 | 84005756 | + |
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FusionProtFeatures for KIAA0556_NECAB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIAA0556 | NECAB2 |
| May influence the stability of microtubules (MT),possibly through interaction with the MT-severing katanin complex.{ECO:0000269|PubMed:26714646}. | May act as a signaling scaffold protein that sensesintracellular calcium. Can modulate ligand-induced internalizationof ADORA2A and coupling efficiency of mGluR5/GRM5; for bothreceptors may regulate signaling activity such as promotingMAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978,ECO:0000305|PubMed:19694902}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 107_118 | 67 | 387 | Calcium binding | 2 |
| Tgene | >NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 73_84 | 67 | 387 | Calcium binding | 1 |
| Tgene | >NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 170_201 | 67 | 387 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 286_375 | 67 | 387 | Domain | Note=ABM |
| Tgene | >NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 94_129 | 67 | 387 | Domain | EF-hand 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KIAA0556 | chr16:27585277 | chr16:84005756 | ENST00000261588 | + | 2 | 28 | 613_643 | 21 | 1619 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >KIAA0556 | chr16:27585277 | chr16:84005756 | ENST00000261588 | + | 2 | 28 | 1614_1617 | 21 | 1619 | Compositional bias | Note=Poly-Arg |
| Tgene | NECAB2 | chr16:27585277 | chr16:84005756 | ENST00000305202 | + | 0 | 13 | 60_95 | 67 | 387 | Domain | EF-hand 1 |
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FusionGeneSequence for KIAA0556_NECAB2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KIAA0556_ENST00000261588_chr16_27585277_+_NECAB2_ENST00000305202_chr16_84005756_+_341aa MDGQTLRKAERSWSCSREKKEIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLAS LETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHK LMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KIAA0556_ENST00000261588_chr16_27585277_+_NECAB2_ENST00000305202_chr16_84005756_+_1023nt ATGGACGGTCAGACTCTGCGAAAGGCCGAGAGAAGCTGGTCCTGCTCACGAGAGAAAAAGGAGATTTTCCGCCGTGCGGACAAAAATGAT GATGGGAAGCTGTCCTTGGAGGAATTCCAGCTCTTCTTTGCAGATGGCGTCCTTAATGAGAAAGAACTGGAGGATCTCTTTCACACGATT GACTCTGACAACACCAACCATGTGGACACCAAGGAGCTGTGTGATTACTTTGTGGACCACATGGGTGACTATGAGGATGTCCTGGCCTCC CTGGAGACCTTGAATCACTCTGTCCTGAAGGCCATGGGTTATACCAAGAAGGTATATGAGGGTGGGAGCAACGTGGACCAGTTTGTGACC CGCTTCCTCCTGAAGGAGACGGCCAATCAGATCCAGTCGCTGCTGAGCTCAGTGGAGAGTGCGGTGGAGGCCATCGAGGAACAGACCAGC CAGCTCCGACAGAACCACATCAAACCCAGCCACAGCGCGGCACAGACCTGGTGTGGAAGCCCCACTCCCGCCTCTGCCCCCAACCACAAG CTCATGGCTATGGAACAAGGCAAGACCCTTCCATCTGCCACGGAGGATGCAAAGGAAGAGGGTCTGGAAGCCCAGATCAGCCGCTTGGCA GAGCTGATTGGGAGGCTGGAGAGCAAAGCACTGTGGTTCGACCTGCAGCAGCGCCTGTCAGATGAAGATGGCACCAACATGCACCTGCAG CTGGTCCGGCAGGAGATGGCCGTGTGCCCCGAGCAACTGAGCGAGTTTCTGGACTCTCTGCGCCAGTATCTGCGGGGGACCACTGGCGTG AGGAACTGCTTCCACATCACTGCCGTGAGGCTCTCAGATGGCTTCACCTTTGTCATCTATGAGTTCTGGGAGACAGAGGAGGCGTGGAAG AGGCACCTGCAGAGCCCCCTGTGTAAGGCGTTCCGGCACGTCAAGGTGGACACACTGAGCCAGCCTGAGGCCCTCTCCAGGATCTTGGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KIAA0556_ENST00000261588_chr16_27585277_+_NECAB2_ENST00000305202_chr16_84005756_+_1472nt GGAACCGCCGCCTCTAGGGATGGACGGTCAGACTCTGCGAAAGGCCGAGAGAAGCTGGTCCTGCTCACGAGAGAAAAAGGAGATTTTCCG CCGTGCGGACAAAAATGATGATGGGAAGCTGTCCTTGGAGGAATTCCAGCTCTTCTTTGCAGATGGCGTCCTTAATGAGAAAGAACTGGA GGATCTCTTTCACACGATTGACTCTGACAACACCAACCATGTGGACACCAAGGAGCTGTGTGATTACTTTGTGGACCACATGGGTGACTA TGAGGATGTCCTGGCCTCCCTGGAGACCTTGAATCACTCTGTCCTGAAGGCCATGGGTTATACCAAGAAGGTATATGAGGGTGGGAGCAA CGTGGACCAGTTTGTGACCCGCTTCCTCCTGAAGGAGACGGCCAATCAGATCCAGTCGCTGCTGAGCTCAGTGGAGAGTGCGGTGGAGGC CATCGAGGAACAGACCAGCCAGCTCCGACAGAACCACATCAAACCCAGCCACAGCGCGGCACAGACCTGGTGTGGAAGCCCCACTCCCGC CTCTGCCCCCAACCACAAGCTCATGGCTATGGAACAAGGCAAGACCCTTCCATCTGCCACGGAGGATGCAAAGGAAGAGGGTCTGGAAGC CCAGATCAGCCGCTTGGCAGAGCTGATTGGGAGGCTGGAGAGCAAAGCACTGTGGTTCGACCTGCAGCAGCGCCTGTCAGATGAAGATGG CACCAACATGCACCTGCAGCTGGTCCGGCAGGAGATGGCCGTGTGCCCCGAGCAACTGAGCGAGTTTCTGGACTCTCTGCGCCAGTATCT GCGGGGGACCACTGGCGTGAGGAACTGCTTCCACATCACTGCCGTGAGGCTCTCAGATGGCTTCACCTTTGTCATCTATGAGTTCTGGGA GACAGAGGAGGCGTGGAAGAGGCACCTGCAGAGCCCCCTGTGTAAGGCGTTCCGGCACGTCAAGGTGGACACACTGAGCCAGCCTGAGGC CCTCTCCAGGATCTTGGTGCCAGCTGCTTGGTGCACGGTGGGACGGGACTGACAGCCTCCCAGAGGCCCGTGGAGGAGCCCACCAGCCCC TTCTTCTTGTGAAGGAAATCCCGTTTTTTTCTAGACAGACACTTTGGTGCAGAAGCTTCTTTTCAATCCATCCTCCACAAGAAGGTGTTT CCCTGTTGTTAAGTGAAGGAGGCCGCCCCTGCCCCCACCTGAGAAGGCAGAGCAGTGTCTGTGCTGCCAGGTCCTGGTGAAGCCCAAGGT TGAAGGGGGCGGCTTCCTGGAGCCAGCACCCCTGCCTCCTGGTCCTGGCCTCTCCCCTACCCCTCACATGGCCACGCATGACCCACACTG ACCACACCCTGCCCTCTTCGGTGACATTCTTCTACCTAGTAGGAGTCATGCCCCTGTAGTGCCCAACCTAGCCAGGTAGCCACCACTGTG |
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FusionGenePPI for KIAA0556_NECAB2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KIAA0556 | XPO1, KIF2A, LLGL2, MAK, ICK | NECAB2 | CCNK, DFFA, PSMA1, CENPO, WDYHV1, VTA1, DGCR6L, TEX11, GTPBP10, NECAB2, RCOR3, LNX1, KANSL1, NEK6, RUNX1T1, CAPN3, CCDC33, NOC4L, FXR2, MED14, USP7, KDM1A, DGCR6, INPP1, BYSL, DAXX, EHHADH, KIFC3, KPNA2, PRKAA2, SDCBP, TTR, AIMP2, EIF4E2, MRPS27, ISCU, NGFRAP1, NIP7, C1orf109, CCDC146, RIC8A, SH2D4A, CARD9, LENG1, GCC1, TTC25, FAM161A, BEX2, KLC4, HAUS1, CCDC151, KLC3, CCDC153, SSC5D, POLR2C, CCDC121, USHBP1, NECAB1, NECAB3, ACBD5, ZYG11B, GOLGA4, PCM1, DCAF10 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA0556_NECAB2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA0556_NECAB2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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