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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18601

FusionGeneSummary for KIAA0368_ZNF484

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0368_ZNF484
Fusion gene ID: 18601
HgeneTgene
Gene symbol

KIAA0368

ZNF484

Gene ID

83744

Gene namezinc finger protein 484
SynonymsBA526D8.4
Cytomap

9q22.31

Type of geneprotein-coding
Descriptionzinc finger protein 484KRAB box containing C2H2 type zinc finger bA526D8.4
Modification date20180519
UniProtAcc

Q5JVG2

Ensembl transtripts involved in fusion geneENST00000338205, ENST00000259335, 
ENST00000374378, ENST00000465499, 
ENST00000395505, ENST00000395506, 
ENST00000375495, ENST00000332591, 
Fusion gene scores* DoF score6 X 7 X 4=1682 X 2 X 2=8
# samples 72
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KIAA0368 [Title/Abstract] AND ZNF484 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0YK-01AKIAA0368chr9

114185479

-ZNF484chr9

95637341

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338205ENST00000395505KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-intronENST00000338205ENST00000395506KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-5UTRENST00000338205ENST00000375495KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-intronENST00000338205ENST00000332591KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-intronENST00000259335ENST00000395505KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-intronENST00000259335ENST00000395506KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-5UTRENST00000259335ENST00000375495KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
5CDS-intronENST00000259335ENST00000332591KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000374378ENST00000395505KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000374378ENST00000395506KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-5UTRENST00000374378ENST00000375495KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000374378ENST00000332591KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000465499ENST00000395505KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000465499ENST00000395506KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-5UTRENST00000465499ENST00000375495KIAA0368chr9

114185479

-ZNF484chr9

95637341

-
intron-intronENST00000465499ENST00000332591KIAA0368chr9

114185479

-ZNF484chr9

95637341

-

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FusionProtFeatures for KIAA0368_ZNF484


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0368

ZNF484

Q5JVG2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0368_ZNF484


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0368_ZNF484


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA0368PCM1, ARF6, PTP4A3, HNRNPA1, CLN3, SIRT7, CCDC57, PCYT1B, FBXO2, GOLGB1, SPECC1L, KIF5B, MYH7, MYH10, SYNE1, ANK2, DST, CKS1B, CPD, DNAJB9, RNF168, HNRNPM, CEP170B, ANKRD17, GAREML, MKI67, MYO10, RABEP1, RAB11FIP4, UIMC1, SF3B2, UBE2G2, UBE2Q1, VPS11, ZNF483, PSMC4, PSMD4, TUBA1A, TUBB4B, TUBB, MYO1B, KIF1B, HSPA1A, VPS36, VPS26A, TMED4, RNF217, MARCH5, KDM2B, KDM2A, FBXO44, CEP152, RCN2, PSMC2, PSMD1, PSMC6, DCTN1, DYNC1I1, PSMA6, FLOT1, FLOT2, PSMA2, SPTAN1, FN1, ADRB2, LATS2, MOB4, PSMC5, PSMD11, PSMD12, PSMD13, PSMD14, PSMD3, PSMD8, RPS23, RPS26, TSR1, TXNL1, UBR4, UCHL5, WDR26, SHFM1, AGTRAP, CMTM5, EGFR, BSG, SPACA1, GNAI2, LYPD3, RP2, HSPB1, CDKN2AIP, DDX1, DNAJB1, DNAJB4, EIF4H, FARSA, HNRNPH1, BAG1, C14orf166, CCT4, EEF1A1, EIF4E, KDM3A, LDHB, NHP2L1, PSMA5, RABIF, RAD23B, RTCB, SMCHD1, TATDN1, XPO1, MAN2B1, TIMM8B, NTRK1, ATP1A1, SLC1A5, USP9X, NOP14, SH3PXD2A, ICE1, HNRNPD, TSNAX, SLC33A1, SGTB, TMEM132A, THOC2, HIGD1A, SPICE1, PLBD2, FOXB1, FOXL1, NANOG, POU5F1, NPY2R, SLC39A9, IL13RA2, C5orf28, SLC18A1, CHRM4, APLNR, OPRM1, SLC10A7, EDNRB, TMEM199, HTR2C, MAS1, SLC2A5, EDEM3, BRCA1ZNF484TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0368_ZNF484


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0368_ZNF484


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource