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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 18565

FusionGeneSummary for KIAA0195_TMEM104

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0195_TMEM104
Fusion gene ID: 18565
HgeneTgene
Gene symbol

KIAA0195

TMEM104

Gene ID

9772

54868

Gene nametransmembrane protein 94transmembrane protein 104
SynonymsKIAA0195-
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 94transmembrane protein 104
Modification date2018051920180519
UniProtAcc

Q8NE00

Ensembl transtripts involved in fusion geneENST00000314256, ENST00000579208, 
ENST00000375248, ENST00000583795, 
ENST00000335464, ENST00000417024, 
ENST00000582773, ENST00000582330, 
ENST00000584171, 
Fusion gene scores* DoF score5 X 3 X 5=757 X 4 X 6=168
# samples 57
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0195 [Title/Abstract] AND TMEM104 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-FP-8631-01AKIAA0195chr17

73482507

+TMEM104chr17

72832066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314256ENST00000335464KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000314256ENST00000417024KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000314256ENST00000582773KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000314256ENST00000582330KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000314256ENST00000584171KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
intron-3CDSENST00000579208ENST00000335464KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
intron-intronENST00000579208ENST00000417024KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
intron-intronENST00000579208ENST00000582773KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
intron-intronENST00000579208ENST00000582330KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
intron-intronENST00000579208ENST00000584171KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
In-frameENST00000375248ENST00000335464KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000375248ENST00000417024KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000375248ENST00000582773KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000375248ENST00000582330KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
5CDS-intronENST00000375248ENST00000584171KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
3UTR-3CDSENST00000583795ENST00000335464KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
3UTR-intronENST00000583795ENST00000417024KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
3UTR-intronENST00000583795ENST00000582773KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
3UTR-intronENST00000583795ENST00000582330KIAA0195chr17

73482507

+TMEM104chr17

72832066

+
3UTR-intronENST00000583795ENST00000584171KIAA0195chr17

73482507

+TMEM104chr17

72832066

+

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FusionProtFeatures for KIAA0195_TMEM104


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0195

TMEM104

Q8NE00

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+53265_851361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+53293_1131361357TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810255_276243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810298_306243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810328_354243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810376_397243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810419_421243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810443_470243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810492_496243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810255_276243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810298_306243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810328_354243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810376_397243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810419_421243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810443_470243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810492_496243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010168_204-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+0101_10-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010226_233-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010255_276-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010298_306-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010328_354-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+01032_36-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010376_397-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010419_421-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010443_470-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010492_496-49315Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+01058_146-49315Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810277_297243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810307_327243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810355_375243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810398_418243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810422_442243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810471_491243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810277_297243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810307_327243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810355_375243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810398_418243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810422_442243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810471_491243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+01011_31-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010147_167-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010205_225-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010234_254-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010277_297-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010307_327-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010355_375-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+01037_57-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010398_418-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010422_442-49315TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582773+010471_491-49315TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321093_11131361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321121_11411361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321168_11881361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321229_12491361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321262_12821361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+5321307_13271361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+532274_2941361357TransmembraneHelical
HgeneKIAA0195chr17:73482507chr17:72832066ENST00000314256+532321_3411361357TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810168_204243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+8101_10243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810226_233243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+81032_36243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+81058_146243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810168_204243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+8101_10243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810226_233243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+81032_36243497Topological domainExtracellular
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+81058_146243497Topological domainCytoplasmic
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+81011_31243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810147_167243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810205_225243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+810234_254243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000335464+81037_57243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+81011_31243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810147_167243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810205_225243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+810234_254243497TransmembraneHelical
TgeneTMEM104chr17:73482507chr17:72832066ENST00000582330+81037_57243497TransmembraneHelical


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FusionGeneSequence for KIAA0195_TMEM104


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIAA0195_ENST00000314256_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_390aa
MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTWKEVWRSSFLHHSNRCSCFHWPGASLMLLAVLLLLGCCGGQPAG
SRGVGLVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQ
HSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLR
NNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRH

>In-frame_KIAA0195_ENST00000375248_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_400aa
MLFKQAELWMPHQGKGNKGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTWKEVWRSSFLHHSNRCSCFHWPGASLMLLAVLLL
LGCCGGQPAGSRGVGLVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLF
GVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTIST
NFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIAA0195_ENST00000314256_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_1170nt
ATGGACCTGAAGGAGAAGCACCTGGGCGAGCCTCCCTCAGCCCTGGGCCTGTCCACGCGGAAGGCCCTCAGCGTCCTGAAGGAGCAGCTG
GAGGCAGTGCTGGAAGGACATCTCAGGGAGCGGAAGAAGTGTCTGACGTGGAAGGAGGTGTGGAGAAGCAGCTTCCTCCACCACAGTAAC
CGCTGCTCCTGCTTCCACTGGCCGGGGGCCTCACTCATGCTACTGGCCGTGCTGCTGCTGCTGGGCTGCTGCGGGGGACAGCCAGCCGGG
AGCCGTGGGGTGGGGCTGGTGAATGCCTCGGCCTTGTTCCTGTTACTGCTTCTCAACCTTGTGCTCATCGGGCGGCAAGACCGGCTGAAG
CGTCGGGAGGTAGAGCGGAGGCTGCGAGGGATCATTGACCAAATCCAAGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGG
CACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAG
CACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTC
TACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTC
GTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGC
AACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCG
CCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATC
CCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCAC
ACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGA

>In-frame_KIAA0195_ENST00000375248_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_1200nt
ATGCTCTTTAAGCAGGCAGAGCTATGGATGCCCCATCAGGGCAAAGGCAACAAAGGCGAGCCTCCCTCAGCCCTGGGCCTGTCCACGCGG
AAGGCCCTCAGCGTCCTGAAGGAGCAGCTGGAGGCAGTGCTGGAAGGACATCTCAGGGAGCGGAAGAAGTGTCTGACGTGGAAGGAGGTG
TGGAGAAGCAGCTTCCTCCACCACAGTAACCGCTGCTCCTGCTTCCACTGGCCGGGGGCCTCACTCATGCTACTGGCCGTGCTGCTGCTG
CTGGGCTGCTGCGGGGGACAGCCAGCCGGGAGCCGTGGGGTGGGGCTGGTGAATGCCTCGGCCTTGTTCCTGTTACTGCTTCTCAACCTT
GTGCTCATCGGGCGGCAAGACCGGCTGAAGCGTCGGGAGGTAGAGCGGAGGCTGCGAGGGATCATTGACCAAATCCAAGCTTTCGCCGTC
ATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTT
GGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTG
TTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATG
TACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACC
AACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGC
GTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCC
TACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTC
AGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIAA0195_ENST00000314256_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_4656nt
ACTCGGCACCTAATTCCGCCAGGCTCCCAGAGGGGCGGTTGCAGCTACAGCCTAGCACGCCGCGTAGCCAATAAGAAGCCAGAATTCCCC
CTATTCTCAAATCCTGACCAATCGGTGGCCTGAACTTTAGCTCTCTGGCCGGCGCCTCTGTTGCCCGGAAGGGAGGCAAGCCCCCTTAGA
GTTGCCAGTAACGGACATGGCTGCGGCCCCCGGAGGAGGGGACGTGAAGTGAGGAGGGGGTTGGGAGGGGAGAGGACGCGGGCGAGGAAG
ACCAGCCCCGGGGCCCCGATGTTGTGACTGTGACAGACTCACTGGGGTTTGTACATGCTGGGGAGGAGCCTTCCTTTCAGGGGTGACCAC
ATTCATCTGGGCATGCCTGCAGTACTCTTGGCCCATGGACCTGAAGGAGAAGCACCTGGGCGAGCCTCCCTCAGCCCTGGGCCTGTCCAC
GCGGAAGGCCCTCAGCGTCCTGAAGGAGCAGCTGGAGGCAGTGCTGGAAGGACATCTCAGGGAGCGGAAGAAGTGTCTGACGTGGAAGGA
GGTGTGGAGAAGCAGCTTCCTCCACCACAGTAACCGCTGCTCCTGCTTCCACTGGCCGGGGGCCTCACTCATGCTACTGGCCGTGCTGCT
GCTGCTGGGCTGCTGCGGGGGACAGCCAGCCGGGAGCCGTGGGGTGGGGCTGGTGAATGCCTCGGCCTTGTTCCTGTTACTGCTTCTCAA
CCTTGTGCTCATCGGGCGGCAAGACCGGCTGAAGCGTCGGGAGGTAGAGCGGAGGCTGCGAGGGATCATTGACCAAATCCAAGCTTTCGC
CGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCT
GTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCT
GGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGA
CATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAG
CACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGA
CCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGG
GGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGG
GGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCAC
GGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTC
GCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTT
GTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGT
GGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCTCCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCG
GGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCATCATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGC
GTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGAC
GGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGC
TAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTC
TACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAG
CCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTG
GGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGT
GGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTTGGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCC
AGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCTCCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTG
CCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAG
AGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCT
GTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCA
GGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCC
GCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTCCCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTC
CATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTG
GCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAAT
CATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATTCATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAAC
CGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGGAACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTC
ACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTT
CTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCAT
CCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCA
GTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTAC
CCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGA
AGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATA
GATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGC
TGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCC
TGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGG
GTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGG
GTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCA
GCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTA

>In-frame_KIAA0195_ENST00000375248_chr17_73482507_+_TMEM104_ENST00000335464_chr17_72832066_+_4484nt
GAATTAATCAGCAGATTGAAGCTCTGCTCTGCTGCGCCTGATTCTGTGCAGCACCCGGCTTCTTGCTCACACACTCTCAGCTGTCTCCGT
CTCTTCTCTCCTCTTCTCTCTCTCTCTCTTTTCACCCTCCCCGCTTTGAGGGAGGTGTTGGAAGTTCTTGCAGCTGACTGCTTGTGGCTC
AGACTCTGGCCCATGCTCTTTAAGCAGGCAGAGCTATGGATGCCCCATCAGGGCAAAGGCAACAAAGGCGAGCCTCCCTCAGCCCTGGGC
CTGTCCACGCGGAAGGCCCTCAGCGTCCTGAAGGAGCAGCTGGAGGCAGTGCTGGAAGGACATCTCAGGGAGCGGAAGAAGTGTCTGACG
TGGAAGGAGGTGTGGAGAAGCAGCTTCCTCCACCACAGTAACCGCTGCTCCTGCTTCCACTGGCCGGGGGCCTCACTCATGCTACTGGCC
GTGCTGCTGCTGCTGGGCTGCTGCGGGGGACAGCCAGCCGGGAGCCGTGGGGTGGGGCTGGTGAATGCCTCGGCCTTGTTCCTGTTACTG
CTTCTCAACCTTGTGCTCATCGGGCGGCAAGACCGGCTGAAGCGTCGGGAGGTAGAGCGGAGGCTGCGAGGGATCATTGACCAAATCCAA
GCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTC
CGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTC
ACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGC
CTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTC
ACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGG
GTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGC
ATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTT
GGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATT
TTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCC
CACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAG
CTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGG
TGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCTCCCACATCTTCCAACACGCTTCACCCCCAACCCTACTT
CCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCATCATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCC
CATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTG
CCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACA
AGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGC
ATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCC
CACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACA
TGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGG
CTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTTGGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCC
AGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCTCCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTT
TCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTG
GAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCC
CCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGG
GATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGC
CTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTCCCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGC
CCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGG
AAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCT
AATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATTCATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAG
TCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGGAACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGG
GGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATG
CCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCC
ACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCC
CGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACA
GCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTC
CCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCC
AGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGC
CACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGC
CCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCC
AAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGA
CTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCAT
TTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGC


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FusionGenePPI for KIAA0195_TMEM104


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA0195CDK5, FIBP, LYPD3, DLK1, PTGER3, TNFRSF10A, SLC17A2, RBM3TMEM104USP36, HTR3C, SLC22A16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0195_TMEM104


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0195_TMEM104


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource