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Fusion gene ID: 18547 |
FusionGeneSummary for KHSRP_ZNF441 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KHSRP_ZNF441 | Fusion gene ID: 18547 | Hgene | Tgene | Gene symbol | KHSRP | ZNF441 | Gene ID | 8570 | 126068 |
| Gene name | KH-type splicing regulatory protein | zinc finger protein 441 | |
| Synonyms | FBP2|FUBP2|KSRP | - | |
| Cytomap | 19p13.3 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | far upstream element-binding protein 2FUSE-binding protein 2p75 | zinc finger protein 441 | |
| Modification date | 20180527 | 20180403 | |
| UniProtAcc | Q92945 | Q8N8Z8 | |
| Ensembl transtripts involved in fusion gene | ENST00000398148, | ENST00000454339, ENST00000357901, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: KHSRP [Title/Abstract] AND ZNF441 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KHSRP | GO:0043488 | regulation of mRNA stability | 16126846 |
| Hgene | KHSRP | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 16126846 |
| Hgene | KHSRP | GO:0061014 | positive regulation of mRNA catabolic process | 16126846 |
| Hgene | KHSRP | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 16126846 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-8052-01A | KHSRP | chr19 | 6421289 | - | ZNF441 | chr19 | 11889145 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000398148 | ENST00000454339 | KHSRP | chr19 | 6421289 | - | ZNF441 | chr19 | 11889145 | + |
| 5CDS-5UTR | ENST00000398148 | ENST00000357901 | KHSRP | chr19 | 6421289 | - | ZNF441 | chr19 | 11889145 | + |
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FusionProtFeatures for KHSRP_ZNF441 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KHSRP | ZNF441 |
| Binds to the dendritic targeting element and may play arole in mRNA trafficking (By similarity). Part of a ternarycomplex that binds to the downstream control sequence (DCS) of thepre-mRNA. Mediates exon inclusion in transcripts that are subjectto tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activategene expression. Also involved in degradation of inherentlyunstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644,ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. | May be involved in transcriptional regulation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KHSRP_ZNF441 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KHSRP_ZNF441 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KHSRP | PUF60, EXOSC2, PARN, PTBP2, HNRNPA1, HNRNPH1, A1CF, PSMA3, GSK3B, STK3, GADD45A, ELAVL1, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RAE1, CPLX1, CIRBP, ASF1B, STRIP1, FN1, VCAM1, UBL4A, ITGA4, MPG, CD81, TARDBP, APBB1, GARS, GFPT1, HNRNPD, ALDH16A1, NAP1L4, WWOX, LGR4, UBC, STAU1, HUWE1, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, MAEL, CHCHD2, CPSF6, CPSF7, FUBP3, HTRA2, EIF4B, RAD54L2, SMARCA2, KYNU, NUP50, PRDX2, PRDX5, SIN3A, SMARCC1, SMARCC2, SYMPK, NTRK1, SCARNA22, MKNK2, FOS, JUN, FOXF1, CRY2, MCM2, NANOG, U2AF2, KLHL12, BRCA1, UBE2I, DROSHA, DGCR8, MIRLET7A1, MIRLET7A3 | ZNF441 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KHSRP_ZNF441 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KHSRP | Q92945 | DB11638 | Artenimol | Far upstream element-binding protein 2 | small molecule | approved|investigational |
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RelatedDiseases for KHSRP_ZNF441 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KHSRP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
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