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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 18525

FusionGeneSummary for KEAP1_EYA2

check button Fusion gene summary
Fusion gene informationFusion gene name: KEAP1_EYA2
Fusion gene ID: 18525
HgeneTgene
Gene symbol

KEAP1

EYA2

Gene ID

9817

2139

Gene namekelch like ECH associated protein 1EYA transcriptional coactivator and phosphatase 2
SynonymsINrf2|KLHL19EAB1
Cytomap

19p13.2

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionkelch-like ECH-associated protein 1KEAP1 delta Ccytosolic inhibitor of Nrf2kelch-like family member 19kelch-like protein 19eyes absent homolog 2
Modification date2018052720180523
UniProtAcc

Q14145

O00167

Ensembl transtripts involved in fusion geneENST00000171111, ENST00000393623, 
ENST00000588024, 		ENST00000357410, 
ENST00000327619, ENST00000497428, 
ENST00000317304, 
Fusion gene scores* DoF score2 X 2 X 2=811 X 7 X 8=616
# samples 216
** MAII scorelog2(2/8*10)=1.32192809488736log2(16/616*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KEAP1 [Title/Abstract] AND EYA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKEAP1

GO:0010499

proteasomal ubiquitin-independent protein catabolic process

15983046

HgeneKEAP1

GO:0016567

protein ubiquitination

15983046

TgeneEYA2

GO:0016576

histone dephosphorylation

19351884


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-49-AARE-01AKEAP1chr19

10599868

-EYA2chr20

45797787

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000171111ENST00000357410KEAP1chr19

10599868

-EYA2chr20

45797787

+
In-frameENST00000171111ENST00000327619KEAP1chr19

10599868

-EYA2chr20

45797787

+
5CDS-intronENST00000171111ENST00000497428KEAP1chr19

10599868

-EYA2chr20

45797787

+
5CDS-intronENST00000171111ENST00000317304KEAP1chr19

10599868

-EYA2chr20

45797787

+
Frame-shiftENST00000393623ENST00000357410KEAP1chr19

10599868

-EYA2chr20

45797787

+
Frame-shiftENST00000393623ENST00000327619KEAP1chr19

10599868

-EYA2chr20

45797787

+
5CDS-intronENST00000393623ENST00000497428KEAP1chr19

10599868

-EYA2chr20

45797787

+
5CDS-intronENST00000393623ENST00000317304KEAP1chr19

10599868

-EYA2chr20

45797787

+
intron-3CDSENST00000588024ENST00000357410KEAP1chr19

10599868

-EYA2chr20

45797787

+
intron-3CDSENST00000588024ENST00000327619KEAP1chr19

10599868

-EYA2chr20

45797787

+
intron-intronENST00000588024ENST00000497428KEAP1chr19

10599868

-EYA2chr20

45797787

+
intron-intronENST00000588024ENST00000317304KEAP1chr19

10599868

-EYA2chr20

45797787

+

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FusionProtFeatures for KEAP1_EYA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KEAP1

Q14145

EYA2

O00167

Acts as a substrate adapter protein for the E3 ubiquitinligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 forubiquitination and degradation by the proteasome, thus resultingin the suppression of its transcriptional activity and therepression of antioxidant response element-mediated detoxifyingenzyme gene expression. Retains NFE2L2/NRF2 and may also retainBPTF in the cytosol. Targets PGAM5 for ubiquitination anddegradation by the proteasome. {ECO:0000269|PubMed:14585973,ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695,ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56184_286569625DomainNote=BACK
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-5677_149569625DomainBTB
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56184_286569625DomainNote=BACK
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-5677_149569625DomainBTB
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56301_310569625MotifNote=Nuclear export signal
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56301_310569625MotifNote=Nuclear export signal
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56327_372569625RepeatNote=Kelch 1
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56373_423569625RepeatNote=Kelch 2
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56424_470569625RepeatNote=Kelch 3
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56471_517569625RepeatNote=Kelch 4
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56518_564569625RepeatNote=Kelch 5
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56327_372569625RepeatNote=Kelch 1
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56373_423569625RepeatNote=Kelch 2
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56424_470569625RepeatNote=Kelch 3
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56471_517569625RepeatNote=Kelch 4
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56518_564569625RepeatNote=Kelch 5

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKEAP1chr19:10599868chr20:45797787ENST00000171111-56565_611569625RepeatNote=Kelch 6
HgeneKEAP1chr19:10599868chr20:45797787ENST00000393623-56565_611569625RepeatNote=Kelch 6


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FusionGeneSequence for KEAP1_EYA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000357410_chr20_45797787_+_134aa
DCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKA

>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000327619_chr20_45797787_+_213aa
DCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAE
LEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000357410_chr20_45797787_+_402nt
GATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCAC
AGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGG
GTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCT
GTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGAC

>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000327619_chr20_45797787_+_639nt
GATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCAC
AGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGG
GTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAG
CTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTC
ACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACC
AAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAG
GAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000357410_chr20_45797787_+_3369nt
GATTGCGCCACTGCACTCCAGCCTGGGCGTGCAGATCAGAGCGAGACCTTGTCTCTAAAGGAAAAAAAAAAAGAAAGAAAGAAAGAAAAG
AAAAGAAAAGAAAACCTAGCGAGGTAGATAATTTTCCCTAGATCCTGCGGCCGCCGGACCACGAGGCCGGCGCTGTGCGTTGTTAAAAGG
AGAATAGCAGATGGTGGCGCGCAGCCCCGCGAGGAGACATCCAGCAACGAAATCGGGAGATGGAAGGGACAGTGAGAAGGGGGGCCTGGC
TGTGCGCCCCCGCCCGATGCCCCACTCCTCGCCGACGGGCGCCGGGCACCTGCGGGAAGGGCGGGAGAATCGCCGCTCCTTTCCCGCCGC
GCCCTTTCCGCCCTCTCCCCGCCTCCTTTTCGGGCGTCCCGAGGCCGCTCCCCAACCGACAACCAAGACCCCGCAGGCCACGCAGCCCTG
GAGCCGAGGCCCCCCGACGGCGGAGGCGCCCGCGGGTCCCCTACAGCCAAGGTCCCTGAGTGCCAGAGGTGGTGGTGTTGCTTATCTTCT
GGAACCCCATGCAGCCAGATCCCAGGCCTAGCGGGGCTGGGGCCTGCTGCCGATTCCTGCCCCTGCAGTCACAGTGCCCTGAGGGGGCAG
GGGACGCGGTGATGTACGCCTCCACTGAGTGCAAGGCGGAGGTGACGCCCTCCCAGCATGGCAACCGCACCTTCAGCTACACCCTGGAGG
ATCATACCAAGCAGGCCTTTGGCATCATGAACGAGCTGCGGCTCAGCCAGCAGCTGTGTGACGTCACACTGCAGGTCAAGTACCAGGATG
CACCGGCCGCCCAGTTCATGGCCCACAAGGTGGTGCTGGCCTCATCCAGCCCTGTCTTCAAGGCCATGTTCACCAACGGGCTGCGGGAGC
AGGGCATGGAGGTGGTGTCCATTGAGGGTATCCACCCCAAGGTCATGGAGCGCCTCATTGAATTCGCCTACACGGCCTCCATCTCCATGG
GCGAGAAGTGTGTCCTCCACGTCATGAACGGTGCTGTCATGTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTTCCTGGTGCAGC
AGCTGGACCCCAGCAATGCCATCGGCATCGCCAACTTCGCTGAGCAGATTGGCTGTGTGGAGTTGCACCAGCGTGCCCGGGAGTACATCT
ACATGCATTTTGGGGAGGTGGCCAAGCAAGAGGAGTTCTTCAACCTGTCCCACTGCCAACTGGTGACCCTCATCAGCCGGGACGACCTGA
ACGTGCGCTGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGACGGTTCTACGTCCAGGCGCTGC
TGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTCCTGCAGATGCAGCTGCAGAAGTGCGAGATCCTGCAGTCCGACTCCCGCTGCA
AGGACTACCTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGGGCGCCCAAGGTGGGCCGCCTGA
TCTACACCGCGGGCGGCTACTTCCGACAGTCGCTCAGCTACCTGGAGGCTTACAACCCCAGTGACGGCACCTGGCTCCGGTTGGCGGACC
TGCAGGTGCCGCGGAGCGGCCTGGCCGGCTGCGTGGTGGGCGGGCTGTTGTACGCCGTGGGCGGCAGGAACAACTCGCCCGACGGCAACA
CCGACTCCAGCGCCCTGGACTGTTACAACCCCATGACCAATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCCCGTAACCGCATCGGGG
TGGGGGTCATCGATGGCCACATCTATGCCGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTGGAGAGGTATGAGCCAGAGCGGG
ATGAGTGGCACTTGGTGGCCCCAATGCTGACACGAAGGATCGGGGTGGGCGTGGCTGTCCTCAATCGTCTCCTTTATGCCGTGGGGGGCT
TTGACGGGACAAACCGCCTTAATTCAGCTGAGTGTTACTACCCAGAGAGGAACGAGTGGCGAATGATCACAGCAATGAACACCATCCGAA
GCGGGGCAGGCGTCTGCGTCCTGCACAACTGTATCTATGCTGCTGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGCTACG
ATGTGGAAACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACTGTCCACCAGGGGAGAATCTACG
TCCTTGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGC
TTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTAC
CGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGA
AAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCAC
GCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACC
CCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCA
GTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGG
AAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGG
AGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTC
TTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTT
GTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACT
TGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATG

>In-frame_KEAP1_ENST00000171111_chr19_10599868_-_EYA2_ENST00000327619_chr20_45797787_+_3606nt
GATTGCGCCACTGCACTCCAGCCTGGGCGTGCAGATCAGAGCGAGACCTTGTCTCTAAAGGAAAAAAAAAAAGAAAGAAAGAAAGAAAAG
AAAAGAAAAGAAAACCTAGCGAGGTAGATAATTTTCCCTAGATCCTGCGGCCGCCGGACCACGAGGCCGGCGCTGTGCGTTGTTAAAAGG
AGAATAGCAGATGGTGGCGCGCAGCCCCGCGAGGAGACATCCAGCAACGAAATCGGGAGATGGAAGGGACAGTGAGAAGGGGGGCCTGGC
TGTGCGCCCCCGCCCGATGCCCCACTCCTCGCCGACGGGCGCCGGGCACCTGCGGGAAGGGCGGGAGAATCGCCGCTCCTTTCCCGCCGC
GCCCTTTCCGCCCTCTCCCCGCCTCCTTTTCGGGCGTCCCGAGGCCGCTCCCCAACCGACAACCAAGACCCCGCAGGCCACGCAGCCCTG
GAGCCGAGGCCCCCCGACGGCGGAGGCGCCCGCGGGTCCCCTACAGCCAAGGTCCCTGAGTGCCAGAGGTGGTGGTGTTGCTTATCTTCT
GGAACCCCATGCAGCCAGATCCCAGGCCTAGCGGGGCTGGGGCCTGCTGCCGATTCCTGCCCCTGCAGTCACAGTGCCCTGAGGGGGCAG
GGGACGCGGTGATGTACGCCTCCACTGAGTGCAAGGCGGAGGTGACGCCCTCCCAGCATGGCAACCGCACCTTCAGCTACACCCTGGAGG
ATCATACCAAGCAGGCCTTTGGCATCATGAACGAGCTGCGGCTCAGCCAGCAGCTGTGTGACGTCACACTGCAGGTCAAGTACCAGGATG
CACCGGCCGCCCAGTTCATGGCCCACAAGGTGGTGCTGGCCTCATCCAGCCCTGTCTTCAAGGCCATGTTCACCAACGGGCTGCGGGAGC
AGGGCATGGAGGTGGTGTCCATTGAGGGTATCCACCCCAAGGTCATGGAGCGCCTCATTGAATTCGCCTACACGGCCTCCATCTCCATGG
GCGAGAAGTGTGTCCTCCACGTCATGAACGGTGCTGTCATGTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTTCCTGGTGCAGC
AGCTGGACCCCAGCAATGCCATCGGCATCGCCAACTTCGCTGAGCAGATTGGCTGTGTGGAGTTGCACCAGCGTGCCCGGGAGTACATCT
ACATGCATTTTGGGGAGGTGGCCAAGCAAGAGGAGTTCTTCAACCTGTCCCACTGCCAACTGGTGACCCTCATCAGCCGGGACGACCTGA
ACGTGCGCTGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGACGGTTCTACGTCCAGGCGCTGC
TGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTCCTGCAGATGCAGCTGCAGAAGTGCGAGATCCTGCAGTCCGACTCCCGCTGCA
AGGACTACCTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGGGCGCCCAAGGTGGGCCGCCTGA
TCTACACCGCGGGCGGCTACTTCCGACAGTCGCTCAGCTACCTGGAGGCTTACAACCCCAGTGACGGCACCTGGCTCCGGTTGGCGGACC
TGCAGGTGCCGCGGAGCGGCCTGGCCGGCTGCGTGGTGGGCGGGCTGTTGTACGCCGTGGGCGGCAGGAACAACTCGCCCGACGGCAACA
CCGACTCCAGCGCCCTGGACTGTTACAACCCCATGACCAATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCCCGTAACCGCATCGGGG
TGGGGGTCATCGATGGCCACATCTATGCCGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTGGAGAGGTATGAGCCAGAGCGGG
ATGAGTGGCACTTGGTGGCCCCAATGCTGACACGAAGGATCGGGGTGGGCGTGGCTGTCCTCAATCGTCTCCTTTATGCCGTGGGGGGCT
TTGACGGGACAAACCGCCTTAATTCAGCTGAGTGTTACTACCCAGAGAGGAACGAGTGGCGAATGATCACAGCAATGAACACCATCCGAA
GCGGGGCAGGCGTCTGCGTCCTGCACAACTGTATCTATGCTGCTGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGCTACG
ATGTGGAAACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACTGTCCACCAGGGGAGAATCTACG
TCCTTGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGC
TTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTAC
CGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGA
GCTGAGCTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTG
CTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGT
GCAACCAAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTG
GAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAG
CTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTC
CAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAA
TGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGT
AAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATT
TATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTG
GTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGG
AAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGC
TACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACAT


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FusionGenePPI for KEAP1_EYA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KEAP1ETF1, NFE2L2, MYO7A, CUL3, AMER1, ARCN1, BBS1, GBAS, MAD2L1, MAZ, PFAS, SQSTM1, SLK, ZRANB1, USP11, BTRC, OSBPL10, COPG1, VWA8, GET4, TMEM160, FAM129B, MCMBP, TSC22D4, RBM45, SASS6, PGAM5, GABPA, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, RBX1, CUL2, KEAP1, IKBKB, NFE2L1, RELA, IRF1, AK4, NEIL2, KPNA6, IPO11, ENC1, TERF1, KLHL2, BPTF, SESN2, SESN1, DDIT3, DPP3, FAM117B, MCM3, WDR1, TSC22D2, FAM46A, NPM1, CLU, BAD, CAT, SNRPN, PDCD6IP, GLRX5, PIDD1, PRKCE, HSP90AA1, BCL2, GPRASP2, XPO1, PTMA, FBXW11, GYPA, PRKAG1, RECK, ATG5, NUDT4, MAPKBP1, KLHL3, LSM3, ZSCAN32, OXR1, CCNB1IP1, WDR83, UBC, SYNE4, MLST8, NEU2, CDK13, MED4, CEP135, CCNB1, MYH7, POLR2F, TUBG1, BAG3, GAR1, POLR3E, FERMT3, NAF1, BOD1L1, TRIM15, EGFR, HSP90AB1, PALB2, CDH1, PAQR3, USP15, CDH5, LEPREL2, APP, ZC3H18, SSH3, BRCA2, BRCA1, RAD51, PPP1R13L, UBE2A, CDK20, CTTNEYA2DMRTB1, RBPMS, SIX4, GNAZ, GNAI2, SIX1, MMS19, ZNF609, TRPS1, NCOR2, CGN, ARID1A, ARID1B, KMT2D, BCOR, NCOR1, TFAP2A, GSE1, CEP85, TLE3, RBM20, KDM6A, PRRC2B, TNRC6A, RAVER1, SEC16A, PUM1, HELZ, CIC, CCDC18, SDCCAG3, KIF14, CNOT1, CEP192, LZTS2, AGO2, NBN, BAG3, MIA3, EYA2, THEM6, PHKG2, CGRRF1, TMEM9, PHKB, NPPC, PHKA2, DUSP1, GPX8, FAM3A, NDUFAF3, NDUFAF4, GMPPB, TMCO1, DCD, PHKA1, CYC1, NDUFA9, GNB2, PIGT, CCDC28A, GDAP1, QPCTL, TIMM21, ETFB, SCO1, ACAD9, AKR7A2, DCAF11, NME1, IDE, LOC442497, DNAJB12, GMPPA, C2orf47, OXA1L, PNKD, UQCRFS1P1, VAPB, SIX2, CCDC85C, AATK, ROR2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KEAP1_EYA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKEAP1Q14145DB08908Dimethyl fumarateKelch-like ECH-associated protein 1small moleculeapproved|investigational

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RelatedDiseases for KEAP1_EYA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKEAP1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneKEAP1C0007134Renal Cell Carcinoma1CTD_human
HgeneKEAP1C0016978gallbladder neoplasm1CTD_human
HgeneKEAP1C0017178Gastrointestinal Diseases1CTD_human
HgeneKEAP1C0019158Hepatitis1CTD_human
HgeneKEAP1C0022593Keratosis1CTD_human
HgeneKEAP1C0033578Prostatic Neoplasms1CTD_human