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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18487

FusionGeneSummary for KDM5B_OXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM5B_OXR1
Fusion gene ID: 18487
HgeneTgene
Gene symbol

KDM5B

OXR1

Gene ID

10765

55074

Gene namelysine demethylase 5Boxidation resistance 1
SynonymsCT31|JARID1B|PLU-1|PLU1|PPP1R98|PUT1|RBBP2H1A|RBP2-H1Nbla00307|TLDC3
Cytomap

1q32.1

8q23.1

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative Doxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307
Modification date2018052320180519
UniProtAcc

Q9UGL1

Q8N573

Ensembl transtripts involved in fusion geneENST00000367265, ENST00000367264, 
ENST00000456180, 		ENST00000445937, 
ENST00000531443, ENST00000517566, 
ENST00000452423, ENST00000442977, 
ENST00000521963, ENST00000312046, 
ENST00000449762, ENST00000297447, 
ENST00000521592, ENST00000497705, 
Fusion gene scores* DoF score8 X 6 X 7=33611 X 10 X 4=440
# samples 912
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM5B [Title/Abstract] AND OXR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM5B

GO:0034720

histone H3-K4 demethylation

20228790


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP208834KDM5Bchr1

202777228

-OXR1chr8

107749747

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367265ENST00000445937KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000531443KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000517566KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000452423KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000442977KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000521963KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000312046KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000449762KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000297447KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-5UTRENST00000367265ENST00000521592KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367265ENST00000497705KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000445937KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000531443KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000517566KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000452423KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000442977KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000521963KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000312046KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000449762KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000297447KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-5UTRENST00000367264ENST00000521592KDM5Bchr1

202777228

-OXR1chr8

107749747

+
5CDS-intronENST00000367264ENST00000497705KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000445937KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000531443KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000517566KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000452423KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000442977KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000521963KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000312046KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000449762KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000297447KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-5UTRENST00000456180ENST00000521592KDM5Bchr1

202777228

-OXR1chr8

107749747

+
intron-intronENST00000456180ENST00000497705KDM5Bchr1

202777228

-OXR1chr8

107749747

+

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FusionProtFeatures for KDM5B_OXR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM5B

Q9UGL1

OXR1

Q8N573

Histone demethylase that demethylates 'Lys-4' of histoneH3, thereby playing a central role in histone code(PubMed:24952722, PubMed:27214403, PubMed:28262558). Does notdemethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylatestrimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts asa transcriptional corepressor for FOXG1B and PAX9. Favors theproliferation of breast cancer cells by repressing tumorsuppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). Incontrast, may act as a tumor suppressor for melanoma. Repressesthe CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptionalactivation of the core clock component PER2 (By similarity).{ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635,ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161,ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722,ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168,ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM5B_OXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM5B_OXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM5BFOXG1, PAX9, PRPF4, CACNA1H, CDC20, PCNX, SMARCC2, DGKQ, CACNA1A, NR4A3, BMP2K, VGLL3, CDX2, CBX4, SLITRK3, AXIN2, FOXC2, ONECUT2, MAF, ELF4, SLC39A6, BRD4, RNF43, RBM15B, PRDM13, GTF2A1, DBNL, CECR6, RHOBTB2, TAF2, SHOX2, ARID1B, HOXA1, GRIN2B, MEOX2, ZNF217, RCOR1, RB1, AR, LMO2, KLF10, HDAC1, CHD3, KDM1A, MTA2, MTA3, HDAC2, RBBP7, RBBP4, MBD2, MBD3, HDAC4, HDAC5, HDAC7, NCOR1, ELAVL1, TFAP2C, MYC, FBXW11, FAM90A1, KRAS, TSPYL6, TRIM25OXR1LIG4, GTF2E1, NMI, RPL24, TOLLIP, VPS35, KEAP1, MYO1C, IQGAP1, DUSP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM5B_OXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM5B_OXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM5BC0009375Colonic Neoplasms1CTD_human