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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18476

FusionGeneSummary for KDM4C_PTPRD

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4C_PTPRD
Fusion gene ID: 18476
HgeneTgene
Gene symbol

KDM4C

PTPRD

Gene ID

23081

5789

Gene namelysine demethylase 4Cprotein tyrosine phosphatase, receptor type D
SynonymsGASC1|JHDM3C|JMJD2C|TDRD14CHPTP|HPTPD|HPTPDELTA|PTPD|RPTPDELTA
Cytomap

9p24.1

9p24.1-p23

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14Creceptor-type tyrosine-protein phosphatase deltaR-PTP-deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta
Modification date2018052320180522
UniProtAcc

Q9H3R0

P23468

Ensembl transtripts involved in fusion geneENST00000535193, ENST00000543771, 
ENST00000381306, ENST00000381309, 
ENST00000442236, ENST00000489243, 
ENST00000536108, ENST00000428870, 
ENST00000401787, 
ENST00000381196, 
ENST00000360074, ENST00000537002, 
ENST00000397617, ENST00000358503, 
ENST00000397611, ENST00000355233, 
ENST00000356435, ENST00000540109, 
ENST00000486161, ENST00000397606, 
ENST00000463477, ENST00000471274, 
Fusion gene scores* DoF score11 X 8 X 10=88013 X 12 X 8=1248
# samples 1213
** MAII scorelog2(12/880*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/1248*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4C [Title/Abstract] AND PTPRD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

HgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

HgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A7AQ-01AKDM4Cchr9

6990524

+PTPRDchr9

10341017

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000535193ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000535193ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000535193ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000543771ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000543771ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000381306ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381306ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000381309ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000381309ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-5UTRENST00000442236ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000442236ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-5UTRENST00000489243ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000489243ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000536108ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000536108ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-5UTRENST00000428870ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
5CDS-intronENST00000428870ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000381196KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000360074KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000537002KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000397617KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000358503KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000397611KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000355233KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000356435KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000540109KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000486161KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000397606KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-5UTRENST00000401787ENST00000463477KDM4Cchr9

6990524

+PTPRDchr9

10341017

-
intron-intronENST00000401787ENST00000471274KDM4Cchr9

6990524

+PTPRDchr9

10341017

-

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FusionProtFeatures for KDM4C_PTPRD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4C

Q9H3R0

PTPRD

P23468

Can bidirectionally induce pre- and post-synapticdifferentiation of neurons by mediating interaction with IL1RAPand IL1RAPL1 trans-synaptically. Involved in pre-synapticdifferentiation through interaction with SLITRK2.{ECO:0000250|UniProtKB:Q64487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM4C_PTPRD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KDM4C_PTPRD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM4CKDM4A, KDM4C, HIST1H3A, H3F3A, PPARG, HDAC1, HDAC3, HIST2H3C, SHMT2, MOV10, NXF1, TRIM25PTPRDPPFIA1, PTPRS, LPAR6, IL2RG, SCN2B, LRRTM2, PPFIA2, PPFIA3, EGFR, COPG2, HADHA, HADHB, TPP2, DSC3, TRIO, LRRN1, PCDHB16, PIANP, LITAF, CD83, ICOSLG, PMEL, PCDH20, IZUMO1, GPR37, ABCG8, PCDHGB4, LILRB4, C19orf45, ARHGAP36, IL17RD, LINGO2, FYN, STMN4, MILR1, TMEM52B, RPL28, TPCN2, TMEM223, NLGN3, IL20RA, MTNR1A, MTNR1B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM4C_PTPRD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KDM4C_PTPRD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM4CC0025149Medulloblastoma1CTD_human
HgeneKDM4CC0236663Alcohol withdrawal syndrome1PSYGENET
TgenePTPRDC0009404Colorectal Neoplasms2CTD_human
TgenePTPRDC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTPRDC0035258Restless Legs Syndrome1CTD_human
TgenePTPRDC1263846Attention deficit hyperactivity disorder1CTD_human
TgenePTPRDC1458155Mammary Neoplasms1CTD_human