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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18458

FusionGeneSummary for KDM4B_KDM4B

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4B_KDM4B
Fusion gene ID: 18458
HgeneTgene
Gene symbol

KDM4B

KDM4B

Gene ID

23030

23030

Gene namelysine demethylase 4Blysine demethylase 4B
SynonymsJMJD2B|TDRD14BJMJD2B|TDRD14B
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14Blysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14B
Modification date2018052320180523
UniProtAcc

O94953

O94953

Ensembl transtripts involved in fusion geneENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
ENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
Fusion gene scores* DoF score19 X 9 X 12=20529 X 9 X 9=729
# samples 1912
** MAII scorelog2(19/2052*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/729*10)=-2.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4B [Title/Abstract] AND KDM4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792

TgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

TgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL133622KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000159111ENST00000159111KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000159111ENST00000381759KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000159111ENST00000536461KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000159111ENST00000592175KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-3CDSENST00000381759ENST00000159111KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000381759ENST00000381759KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000381759ENST00000536461KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000381759ENST00000592175KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
Frame-shiftENST00000536461ENST00000159111KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000536461ENST00000381759KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000536461ENST00000536461KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
5CDS-intronENST00000536461ENST00000592175KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-3CDSENST00000592175ENST00000159111KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000592175ENST00000381759KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000592175ENST00000536461KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+
intron-intronENST00000592175ENST00000592175KDM4Bchr19

5131096

-KDM4Bchr19

5131229

+

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FusionProtFeatures for KDM4B_KDM4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

KDM4B

O94953

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does notdemethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', witha weaker activity than KDM4A, KDM4C and KDM4D. Demethylation ofLys residue generates formaldehyde and succinate.{ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does notdemethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', witha weaker activity than KDM4A, KDM4C and KDM4D. Demethylation ofLys residue generates formaldehyde and succinate.{ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM4B_KDM4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM4B_KDM4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM4B_KDM4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM4B_KDM4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM4BC0025149Medulloblastoma1CTD_human
TgeneKDM4BC0025149Medulloblastoma1CTD_human