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Fusion gene ID: 18442 |
FusionGeneSummary for KDM4A_MPL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM4A_MPL | Fusion gene ID: 18442 | Hgene | Tgene | Gene symbol | KDM4A | MPL | Gene ID | 9682 | 4352 |
| Gene name | lysine demethylase 4A | MPL proto-oncogene, thrombopoietin receptor | |
| Synonyms | JHDM3A|JMJD2|JMJD2A|TDRD14A | C-MPL|CD110|MPLV|THCYT2|TPOR | |
| Cytomap | 1p34.2-p34.1 | 1p34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 4AjmjC domain-containing histone demethylation protein 3Ajumonji C domain-containing histone demethylase 3Ajumonji domain containing 2jumonji domain containing 2Ajumonji domain-containing protein 2Alysine (K)-specific dem | thrombopoietin receptorTPO-Rmyeloproliferative leukemia proteinmyeloproliferative leukemia virus oncogeneproto-oncogene c-Mpl | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | O75164 | P40238 | |
| Ensembl transtripts involved in fusion gene | ENST00000372396, ENST00000463151, | ENST00000372470, ENST00000413998, | |
| Fusion gene scores | * DoF score | 13 X 12 X 9=1404 | 1 X 1 X 1=1 |
| # samples | 13 | 1 | |
| ** MAII score | log2(13/1404*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KDM4A [Title/Abstract] AND MPL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM4A | GO:0016577 | histone demethylation | 16024779 |
| Hgene | KDM4A | GO:0045892 | negative regulation of transcription, DNA-templated | 16024779 |
| Hgene | KDM4A | GO:0070544 | histone H3-K36 demethylation | 21914792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-2H-A9GJ-01A | KDM4A | chr1 | 44169783 | + | MPL | chr1 | 43805635 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372396 | ENST00000372470 | KDM4A | chr1 | 44169783 | + | MPL | chr1 | 43805635 | + |
| In-frame | ENST00000372396 | ENST00000413998 | KDM4A | chr1 | 44169783 | + | MPL | chr1 | 43805635 | + |
| intron-3CDS | ENST00000463151 | ENST00000372470 | KDM4A | chr1 | 44169783 | + | MPL | chr1 | 43805635 | + |
| intron-3CDS | ENST00000463151 | ENST00000413998 | KDM4A | chr1 | 44169783 | + | MPL | chr1 | 43805635 | + |
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FusionProtFeatures for KDM4A_MPL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM4A | MPL |
| Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a centralrole in histone code (PubMed:26741168). Does not demethylatehistone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylatestrimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has noactivity on mono- and dimethylated residues. Demethylation of Lysresidue generates formaldehyde and succinate. Participates intranscriptional repression of ASCL2 and E2F-responsive promotersvia the recruitment of histone deacetylases and NCOR1,respectively. {ECO:0000269|PubMed:16024779,ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}. Isoform 2: Crucial for muscle differentiation, promotestranscriptional activation of the Myog gene by directing theremoval of repressive chromatin marks at its promoter. Lacks theN-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. | Receptor for thrombopoietin that acts as a primaryregulator of megakaryopoiesis and platelet production. Mayrepresent a regulatory molecule specific for TPO-R-dependentimmune responses. {ECO:0000250|UniProtKB:Q08351}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 142_308 | 1018 | 1065 | Domain | JmjC |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 14_56 | 1018 | 1065 | Domain | JmjN |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 897_954 | 1018 | 1065 | Domain | Note=Tudor 1 |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 955_1011 | 1018 | 1065 | Domain | Note=Tudor 2 |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 709_767 | 1018 | 1065 | Zinc finger | Note=PHD-type 1 |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 772_805 | 1018 | 1065 | Zinc finger | C2HC pre-PHD-type |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 828_885 | 1018 | 1065 | Zinc finger | PHD-type 2 |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 335_338 | 230 | 636 | Compositional bias | Note=Poly-Glu |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 508_513 | 230 | 636 | Compositional bias | Note=Poly-Leu |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 392_486 | 230 | 636 | Domain | Fibronectin type-III 2 |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 474_478 | 230 | 636 | Motif | Note=WSXWS motif |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 528_536 | 230 | 636 | Motif | Note=Box 1 motif |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 514_635 | 230 | 636 | Topological domain | Cytoplasmic |
| Tgene | >MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 492_513 | 230 | 636 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 172_281 | 230 | 636 | Domain | Fibronectin type-III 1 |
| Tgene | MPL | chr1:44169783 | chr1:43805635 | ENST00000372470 | + | 3 | 12 | 26_491 | 230 | 636 | Topological domain | Extracellular |
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FusionGeneSequence for KDM4A_MPL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000372470_chr1_43805635_+_1424aa MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000413998_chr1_43805635_+_1338aa MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000372470_chr1_43805635_+_4272nt ATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGACCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATAC ATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCAAGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGAT GACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGACGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAA GCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGTACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAA TACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATGTGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATT GGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGATCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATG TGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACAGCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCT GTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCTTTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCAC AAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTCCCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACT TTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTGCGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGC AAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCTCCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAA CTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGCCCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCT CCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAGGGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCC AAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATACCACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTG AGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCCCTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGT CTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAGAGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAA CAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAGGGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCT AGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAGAAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGA GTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTGTGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGT TTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTTCCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTA AGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCAGTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCT GAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGAACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACC ATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGACTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGA AATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGATTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATC AACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCGTTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTAT GGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGTGTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTA CGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACGTTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATT GCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCTTCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACT GCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCTTCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCT GACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGATTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACT GCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACCAGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTC AACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACATAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGG GAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCAAGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTT GAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACACTGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCA GCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGCCTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGG ATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTGTGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTT ACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACCATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGC TGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAGAGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGC CACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGGTGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCT TTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACTGGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCAC CCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACACAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTC GGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACCGTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGT CCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCGAGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTG GGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTCCTGCACACTACAGGAGACTGAGGCATGCCCTGTGGCCCTCACTT CCAGACCTGCACCGGGTCCTAGGCCAGTACCTTAGGGACACTGCAGCCCTGAGCCCGCCCAAGGCCACAGTCTCAGATACCTGTGAAGAA GTGGAACCCAGCCTCCTTGAAATCCTCCCCAAGTCCTCAGAGAGGACTCCTTTGCCCCTGTGTTCCTCCCAGGCCCAGATGGACTACCGA AGATTGCAGCCTTCTTGCCTGGGGACCATGCCCCTGTCTGTGTGCCCACCCATGGCTGAGTCAGGGTCCTGCTGTACCACCCACATTGCC >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000413998_chr1_43805635_+_4014nt ATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGACCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATAC ATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCAAGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGAT GACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGACGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAA GCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGTACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAA TACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATGTGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATT GGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGATCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATG TGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACAGCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCT GTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCTTTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCAC AAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTCCCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACT TTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTGCGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGC AAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCTCCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAA CTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGCCCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCT CCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAGGGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCC AAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATACCACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTG AGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCCCTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGT CTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAGAGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAA CAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAGGGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCT AGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAGAAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGA GTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTGTGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGT TTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTTCCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTA AGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCAGTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCT GAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGAACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACC ATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGACTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGA AATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGATTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATC AACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCGTTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTAT GGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGTGTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTA CGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACGTTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATT GCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCTTCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACT GCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCTTCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCT GACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGATTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACT GCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACCAGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTC AACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACATAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGG GAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCAAGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTT GAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACACTGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCA GCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGCCTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGG ATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTGTGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTT ACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACCATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGC TGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAGAGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGC CACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGGTGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCT TTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACTGGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCAC CCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACACAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTC GGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACCGTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGT CCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCGAGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTG GGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTCCTGCACACTACAGGTACCGCCCCCGCCAGGCAGGAGACTGGCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000372470_chr1_43805635_+_4406nt GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC CTGCACACTACAGGAGACTGAGGCATGCCCTGTGGCCCTCACTTCCAGACCTGCACCGGGTCCTAGGCCAGTACCTTAGGGACACTGCAG CCCTGAGCCCGCCCAAGGCCACAGTCTCAGATACCTGTGAAGAAGTGGAACCCAGCCTCCTTGAAATCCTCCCCAAGTCCTCAGAGAGGA CTCCTTTGCCCCTGTGTTCCTCCCAGGCCCAGATGGACTACCGAAGATTGCAGCCTTCTTGCCTGGGGACCATGCCCCTGTCTGTGTGCC >In-frame_KDM4A_ENST00000372396_chr1_44169783_+_MPL_ENST00000413998_chr1_43805635_+_4241nt GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC CTGCACACTACAGGTACCGCCCCCGCCAGGCAGGAGACTGGCGGTGGACCAGGTGGAGCCGAAGGCCTGTAAACAGGCATTCTTGGTTCG CTCTGTGACCCCAGATCTCCGTCCACCGCCCGTGCGCACCTACGGCTTCGCCACTTCCTGCACGTCACCTCTGGGACTCGCCGCGGCTCC |
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FusionGenePPI for KDM4A_MPL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KDM4A | NCOR1, WDR48, KDM4A, KDM4C, HIST1H3A, HDAC1, HDAC3, RB1, AR, WAS, HIST1H4A, RNF8, RNF168, H3F3A, CUL1, FBXL4, MOV10, NXF1, CAPZA1, EPHB2, ZNF131, ZNF414, CCL22, STK11, KDM4B, ABHD5 | MPL | ATXN2L, SOCS1, ANKRA2, YWHAQ, BAG3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | KDM4A | chr1:44169783 | chr1:43805635 | ENST00000372396 | + | 21 | 22 | 597_638 | 1018 | 1065 | NCOR1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KDM4A_MPL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MPL | P40238 | DB05332 | Romiplostim | Thrombopoietin receptor | biotech | approved |
| Tgene | MPL | P40238 | DB06210 | Eltrombopag | Thrombopoietin receptor | small molecule | approved |
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RelatedDiseases for KDM4A_MPL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MPL | C3275998 | THROMBOCYTHEMIA 2 | 5 | ORPHANET;UNIPROT |
| Tgene | MPL | C0836924 | Thrombocytosis | 2 | CTD_human;HPO |
| Tgene | MPL | C1327915 | Congenital amegakaryocytic thrombocytopenia | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | MPL | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | MPL | C0026987 | Myelofibrosis | 1 | HPO;ORPHANET;UNIPROT |
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