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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18434

FusionGeneSummary for KDM3B_KDM3B

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM3B_KDM3B
Fusion gene ID: 18434
HgeneTgene
Gene symbol

KDM3B

KDM3B

Gene ID

51780

51780

Gene namelysine demethylase 3Blysine demethylase 3B
Synonyms5qNCA|C5orf7|JMJD1B|NET225qNCA|C5orf7|JMJD1B|NET22
Cytomap

5q31.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 3BjmjC domain-containing histone demethylation protein 2Bjumonji domain containing 1Bjumonji domain-containing protein 1Blysine (K)-specific demethylase 3Bnuclear protein 5qNCAlysine-specific demethylase 3BjmjC domain-containing histone demethylation protein 2Bjumonji domain containing 1Bjumonji domain-containing protein 1Blysine (K)-specific demethylase 3Bnuclear protein 5qNCA
Modification date2018052320180523
UniProtAcc

Q7LBC6

Q7LBC6

Ensembl transtripts involved in fusion geneENST00000314358, ENST00000394866, 
ENST00000542866, ENST00000508386, 
ENST00000314358, ENST00000394866, 
ENST00000542866, ENST00000508386, 
Fusion gene scores* DoF score1 X 2 X 1=26 X 7 X 3=126
# samples 27
** MAII scorelog2(2/2*10)=3.32192809488736log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM3B [Title/Abstract] AND KDM3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ308590KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
ChiTaRS3.1BF346562KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000314358ENST00000314358KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
Frame-shiftENST00000314358ENST00000394866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
5CDS-intronENST00000314358ENST00000542866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
5CDS-intronENST00000314358ENST00000508386KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
Frame-shiftENST00000394866ENST00000314358KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
Frame-shiftENST00000394866ENST00000394866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
5CDS-intronENST00000394866ENST00000542866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
5CDS-intronENST00000394866ENST00000508386KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-3CDSENST00000542866ENST00000314358KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-3CDSENST00000542866ENST00000394866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-intronENST00000542866ENST00000542866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-intronENST00000542866ENST00000508386KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-3CDSENST00000508386ENST00000314358KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-3CDSENST00000508386ENST00000394866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-intronENST00000508386ENST00000542866KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
intron-intronENST00000508386ENST00000508386KDM3Bchr5

137726928

-KDM3Bchr5

137722245

+
In-frameENST00000314358ENST00000314358KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000314358ENST00000394866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000314358ENST00000542866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
5CDS-intronENST00000314358ENST00000508386KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000394866ENST00000314358KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000394866ENST00000394866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000394866ENST00000542866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
5CDS-intronENST00000394866ENST00000508386KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000542866ENST00000314358KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000542866ENST00000394866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
In-frameENST00000542866ENST00000542866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
5CDS-intronENST00000542866ENST00000508386KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
intron-3CDSENST00000508386ENST00000314358KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
intron-3CDSENST00000508386ENST00000394866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
intron-3CDSENST00000508386ENST00000542866KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+
intron-intronENST00000508386ENST00000508386KDM3Bchr5

137766009

-KDM3Bchr5

137766042

+

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FusionProtFeatures for KDM3B_KDM3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM3B

Q7LBC6

KDM3B

Q7LBC6

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.Demethylation of Lys residue generates formaldehyde and succinate.May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.Demethylation of Lys residue generates formaldehyde and succinate.May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM3B_KDM3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM3B_KDM3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM3B_KDM3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM3B_KDM3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM3BC0274869Toxic effect of heavy metal1CTD_human
TgeneKDM3BC0274869Toxic effect of heavy metal1CTD_human