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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 18424

FusionGeneSummary for KDM2B_RHOF

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2B_RHOF
Fusion gene ID: 18424
HgeneTgene
Gene symbol

KDM2B

RHOF

Gene ID

84678

54509

Gene namelysine demethylase 2Bras homolog family member F, filopodia associated
SynonymsCXXC2|FBXL10|Fbl10|JHDM1B|PCCX2ARHF|RIF
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethyrho-related GTP-binding protein RhoFras homolog family member F (in filopodia)ras homolog gene family, member F (in filopodia)rho family GTPase Rifrho in filopodia
Modification date2018051920180526
UniProtAcc

Q8NHM5

Q9HBH0

Ensembl transtripts involved in fusion geneENST00000377069, ENST00000542973, 
ENST00000377071, ENST00000536437, 
ENST00000538046, ENST00000543852, 
ENST00000267205, ENST00000537265, 
ENST00000537171, ENST00000545544, 
Fusion gene scores* DoF score8 X 6 X 7=3361 X 1 X 1=1
# samples 81
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: KDM2B [Title/Abstract] AND RHOF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM2B

GO:0035518

histone H2A monoubiquitination

16943429

TgeneRHOF

GO:0007015

actin filament organization

11084341


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A7WK-01AKDM2Bchr12

121932382

-RHOFchr12

122231145

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377069ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377069ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377069ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377069ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5UTR-3CDSENST00000542973ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5UTR-5UTRENST00000542973ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5UTR-5UTRENST00000542973ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5UTR-5UTRENST00000542973ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-
In-frameENST00000377071ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377071ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377071ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000377071ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-
Frame-shiftENST00000536437ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000536437ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000536437ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
5CDS-5UTRENST00000536437ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-3CDSENST00000538046ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000538046ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000538046ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000538046ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-3CDSENST00000543852ENST00000267205KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000543852ENST00000537265KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000543852ENST00000537171KDM2Bchr12

121932382

-RHOFchr12

122231145

-
intron-5UTRENST00000543852ENST00000545544KDM2Bchr12

121932382

-RHOFchr12

122231145

-

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FusionProtFeatures for KDM2B_RHOF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2B

Q8NHM5

RHOF

Q9HBH0

Plasma membrane-associated small GTPase which cyclesbetween an active GTP-bound and an inactive GDP-bound state.Causes the formation of thin, actin-rich surface projectionscalled filopodia. Functions cooperatively with CDC42 and Rac togenerate additional structures, increasing the diversity of actin-based morphology.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223409_4305471266Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223409_4305781337Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223178_3465471266DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223178_3465781337DomainJmjC
TgeneRHOFchr12:121932382chr12:122231145ENST00000267205-0548_5646212MotifEffector region
TgeneRHOFchr12:121932382chr12:122231145ENST00000267205-05131_13446212Nucleotide bindingGTP
TgeneRHOFchr12:121932382chr12:122231145ENST00000267205-0573_7746212Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223943_9715471266Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223943_9715781337Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214943_971-54912Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231014_10565471266Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231014_10565781337Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141014_1056-54912Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214409_430-54912Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231059_11055471266DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231059_11055781337DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141059_1105-54912DomainNote=F-box
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214178_346-54912DomainJmjC
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231093_11205471266RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231133_11545471266RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231156_11825471266RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231222_12475471266RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231248_12775471266RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231278_13025471266RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-12231303_13365471266RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231093_11205781337RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231133_11545781337RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231156_11825781337RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231222_12475781337RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231248_12775781337RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231278_13025781337RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-12231303_13365781337RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141093_1120-54912RepeatNote=LRR 1
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141133_1154-54912RepeatNote=LRR 2
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141156_1182-54912RepeatNote=LRR 3
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141222_1247-54912RepeatNote=LRR 4
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141248_1277-54912RepeatNote=LRR 5
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141278_1302-54912RepeatNote=LRR 6
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-2141303_1336-54912RepeatNote=LRR 7
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223606_6525471266Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377069-1223659_7255471266Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223606_6525781337Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000377071-1223659_7255781337Zinc fingerPHD-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214606_652-54912Zinc fingerCXXC-type
HgeneKDM2Bchr12:121932382chr12:122231145ENST00000542973-214659_725-54912Zinc fingerPHD-type
TgeneRHOFchr12:121932382chr12:122231145ENST00000267205-0526_3346212Nucleotide bindingGTP


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FusionGeneSequence for KDM2B_RHOF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KDM2B_ENST00000377069_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_713aa
MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDP
DFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ
TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELK
QGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI
DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESV
KSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT
WPKKTPKHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMNPTSYDNVLIKWFPEVTHFCRGIPMVLI

>In-frame_KDM2B_ENST00000377071_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_744aa
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICY
DVMNPTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFRENVEDVFREA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KDM2B_ENST00000377069_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_2139nt
ATGGAGGCAGAGAAAGACTCTGGAAGAAGATTGCGCCCGATTGACCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAG
ATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAGCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGAT
TTCAACTATGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCCTGATATTTCGAGAAAAGGATGGACTGGGAATTAAGATGCCTGACCCT
GATTTCACAGTCCGAGACGTCAAACTCCTAGTGGGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATG
AGCATGTCCCAGTTTGTGCGTTACTACGAGACGCCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACC
AAGCTGGAGCACTTGGTCAAGCGTCCGACTGTGGTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAG
ACAGAAGCCACGAACGCCATTGCAGAGATGAAGTACCCGAAAGTGAAAAAGTACTGTCTGATGAGCGTGAAAGGTTGTTTCACCGACTTC
CACATCGACTTTGGAGGCACTTCCGTTTGGTACCATGTTTTCCGGGGTGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAATTTG
GCGCTGTACGAGGAGTGGGTGCTGTCAGGCAAACAGAGTGACATCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTGAAG
CAGGGCTACACATTTTTCATCCCTTCCGGTTGGATCCATGCCGTCTACACCCCTGTAGACTCTTTGGTGTTCGGCGGAAACATCCTGCAC
AGCTTTAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGGACAGGACGCGGGTGCAGCCCAAATTCCGTTACCCCTTCTACTATGAG
ATGTGCTGGTATGTCCTGGAGAGATACGTGTACTGTGTGACCCAGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTTATT
GATGCCCCGAGGAAGCCCAGCATAGACGGCTTCTCTTCGGATTCCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAGGAG
GAGGAGGAGAAGGACGAGGAGGGCGAGGGCAGGGACAGGGCACCCAAACCGCCCACCGATGGCTCCACTTCACCCACCAGCACGCCCTCT
GAGGACCAGGAGGCCCTCGGGAAGAAGCCCAAAGCACCTGCCCTGCGATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGTGTG
AAGTCCACCACATTGGCCGTAGACTACCCCAAGACCCCCACCGGCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACTGAG
TTTGAACTGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGGCATCGAGGACCCC
CAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCTAGTCTGGCCATCACTGGGGTCCCTGTGGTGACT
TGGCCAAAGAAGACTCCAAAGCACTACGCCCCATCGGTGTTCGAGAAGTACACGGCCAGCGTGACCGTTGGCAGCAAGGAGGTGACCCTG
AACCTCTACGACACGGCCGGGCAAGAAGACTATGACCGGCTGCGGCCCCTGTCCTACCAGAACACCCACCTCGTGCTCATCTGCTATGAC
GTCATGAATCCCACCAGCTACGACAACGTCCTCATCAAGTGGTTCCCTGAGGTCACGCATTTCTGCCGCGGGATCCCCATGGTGCTCATC
GGCTGCAAGACAGACCTGAGGAAGGACAAGGAGCAGCTGCGGAAGCTCCGGGCCGCCCAGCTGGAGCCCATCACCTACATGCAGGGCCTG
AGCGCCTGCGAACAGATCCGAGCTGCTCTCTACCTGGAATGTTCCGCCAAGTTTCGGGAGAATGTGGAGGACGTCTTCCGGGAGGCCGCC

>In-frame_KDM2B_ENST00000377071_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_2232nt
ATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACGAAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATA
TATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGACCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAG
GAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAGCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAA
GATTTCAACTATGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCCTGATATTTCGAGAAAAGGATGGACTGGGAATTAAGATGCCTGAC
CCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTGGGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAG
ATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACGCCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCAC
ACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTGGTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAG
CAGACAGAAGCCACGAACGCCATTGCAGAGATGAAGTACCCGAAAGTGAAAAAGTACTGTCTGATGAGCGTGAAAGGTTGTTTCACCGAC
TTCCACATCGACTTTGGAGGCACTTCCGTTTGGTACCATGTTTTCCGGGGTGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAAT
TTGGCGCTGTACGAGGAGTGGGTGCTGTCAGGCAAACAGAGTGACATCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTG
AAGCAGGGCTACACATTTTTCATCCCTTCCGGTTGGATCCATGCCGTCTACACCCCTGTAGACTCTTTGGTGTTCGGCGGAAACATCCTG
CACAGCTTTAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGGACAGGACGCGGGTGCAGCCCAAATTCCGTTACCCCTTCTACTAT
GAGATGTGCTGGTATGTCCTGGAGAGATACGTGTACTGTGTGACCCAGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTT
ATTGATGCCCCGAGGAAGCCCAGCATAGACGGCTTCTCTTCGGATTCCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAG
GAGGAGGAGGAGAAGGACGAGGAGGGCGAGGGCAGGGACAGGGCACCCAAACCGCCCACCGATGGCTCCACTTCACCCACCAGCACGCCC
TCTGAGGACCAGGAGGCCCTCGGGAAGAAGCCCAAAGCACCTGCCCTGCGATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGT
GTGAAGTCCACCACATTGGCCGTAGACTACCCCAAGACCCCCACCGGCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACT
GAGTTTGAACTGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGGCATCGAGGAC
CCCCAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCTAGTCTGGCCATCACTGGGGTCCCTGTGGTG
ACTTGGCCAAAGAAGACTCCAAAGCACTACGCCCCATCGGTGTTCGAGAAGTACACGGCCAGCGTGACCGTTGGCAGCAAGGAGGTGACC
CTGAACCTCTACGACACGGCCGGGCAAGAAGACTATGACCGGCTGCGGCCCCTGTCCTACCAGAACACCCACCTCGTGCTCATCTGCTAT
GACGTCATGAATCCCACCAGCTACGACAACGTCCTCATCAAGTGGTTCCCTGAGGTCACGCATTTCTGCCGCGGGATCCCCATGGTGCTC
ATCGGCTGCAAGACAGACCTGAGGAAGGACAAGGAGCAGCTGCGGAAGCTCCGGGCCGCCCAGCTGGAGCCCATCACCTACATGCAGGGC
CTGAGCGCCTGCGAACAGATCCGAGCTGCTCTCTACCTGGAATGTTCCGCCAAGTTTCGGGAGAATGTGGAGGACGTCTTCCGGGAGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KDM2B_ENST00000377069_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_4286nt
CCAACAACAAAACAGCGATGCCACGGCGCTAACGGCGCCCGGTGCCTCCCGGGCTCCCTCCCCGCCCCATACCTCCTCGGGCCGCCGCCC
CCACCCCCCCAAGCCCGGGCCGAGAGCCCCCCCAAATAGCCCGGCCGCGGGCTCCGAGCGCGATCGGCAACAATGTTTACGTTCCGGGGA
TTATGACGTCGACGCCTCCCCCCCCCCACAACTGCTGAAAATGGTTTCCTAGGACTTTGCAAACGGATCTGCCTAAGTGTTGGTGCAAAA
CTTTGTAGATCTCGGCTCTGGCTTGCTTTATTTATTTATTTTTTGGTTTGTTTTCTTTGGTCTTCCCTCCTTCCCCCCTCGGCCAAAATG
CAGGGGGCAGGAGTGTTGACAATTAATTGGTGAACTCTCCTAAAAAAATGGAGGCAGAGAAAGACTCTGGAAGAAGATTGCGCCCGATTG
ACCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCA
GCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGATTTCAACTATGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCC
TGATATTTCGAGAAAAGGATGGACTGGGAATTAAGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTGGGGAGCCGGC
GGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACGCCCGAGGCCC
AGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTGGTAGACCTGG
TGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAGTACCCGAAAG
TGAAAAAGTACTGTCTGATGAGCGTGAAAGGTTGTTTCACCGACTTCCACATCGACTTTGGAGGCACTTCCGTTTGGTACCATGTTTTCC
GGGGTGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAATTTGGCGCTGTACGAGGAGTGGGTGCTGTCAGGCAAACAGAGTGACA
TCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTGAAGCAGGGCTACACATTTTTCATCCCTTCCGGTTGGATCCATGCCG
TCTACACCCCTGTAGACTCTTTGGTGTTCGGCGGAAACATCCTGCACAGCTTTAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGG
ACAGGACGCGGGTGCAGCCCAAATTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGTCCTGGAGAGATACGTGTACTGTGTGACCC
AGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTTATTGATGCCCCGAGGAAGCCCAGCATAGACGGCTTCTCTTCGGATT
CCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAGGAGGAGGAGGAGAAGGACGAGGAGGGCGAGGGCAGGGACAGGGCAC
CCAAACCGCCCACCGATGGCTCCACTTCACCCACCAGCACGCCCTCTGAGGACCAGGAGGCCCTCGGGAAGAAGCCCAAAGCACCTGCCC
TGCGATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGTGTGAAGTCCACCACATTGGCCGTAGACTACCCCAAGACCCCCACCG
GCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACTGAGTTTGAACTGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAAT
CCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGGCATCGAGGACCCCCAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACG
CAGATGATGACCCTAGTCTGGCCATCACTGGGGTCCCTGTGGTGACTTGGCCAAAGAAGACTCCAAAGCACTACGCCCCATCGGTGTTCG
AGAAGTACACGGCCAGCGTGACCGTTGGCAGCAAGGAGGTGACCCTGAACCTCTACGACACGGCCGGGCAAGAAGACTATGACCGGCTGC
GGCCCCTGTCCTACCAGAACACCCACCTCGTGCTCATCTGCTATGACGTCATGAATCCCACCAGCTACGACAACGTCCTCATCAAGTGGT
TCCCTGAGGTCACGCATTTCTGCCGCGGGATCCCCATGGTGCTCATCGGCTGCAAGACAGACCTGAGGAAGGACAAGGAGCAGCTGCGGA
AGCTCCGGGCCGCCCAGCTGGAGCCCATCACCTACATGCAGGGCCTGAGCGCCTGCGAACAGATCCGAGCTGCTCTCTACCTGGAATGTT
CCGCCAAGTTTCGGGAGAATGTGGAGGACGTCTTCCGGGAGGCCGCCAAGGTGGCTCTCAGCGCTCTGAAGAAGGCGCAACGGCAGAAGA
AGCGCCGGCTCTGCCTGCTGCTCTGACCCAGGGCAGACAGACCTCACGACAGCACTGACAGGGCCCGGGGGCCCAGGTGCCGATTGCACC
AGGGAGGCTGCCCCATCCCGACCCTCCAGCTCATGGTGTCTGGGGCCTGCGGCTAGACTCTTGGAACATTCTGGAACTCTCTCCTTTCCT
GGCTGGGGCTCTGACCACAAACTCCCCTCCAGGCTGCCCCTGGGACATGGTGGTGATGTGGGTGCAGGAGCCAGTGTCTGTTGTCGGGAC
TCGCAAGTGCCCTCATCACAGCCACCCCCACCACGAGTGTCTCCCCAGTGCAGACTCAAGTTATGCTTGAAATGAAAAAGTCTATCTGGT
AGTGGGTAAACGTAGACCTGGCACTGTTCCACGCGGGCGCCCCAAGCCTGCCACTCCTGTGTCCCTGCCTCCCTGGGCTCCCGAGATAGG
CACCACTGTATCCTCCAGCTCCTTCCTTCCTTCCCCCAGGAACACGGAGGCCACCGAGGGGGCTGGGCCTATCAGGAGGACACAGGCTGC
AGCCTGGCACCCACCCCTCCCATCTCCACCCCACATGGAAGACTTGTCTTCAACTTGGCCACTGTCTTTGCAGAGCTGGGCACATGTGCC
CAGGGGGCAGAAAAAATGGCTTCTCAGTTGTTAAAAGTATACCCTGGACCACCCATCTGACCATCTCCTTAAGGTTTCACCCAAAGCCCC
CAGTGTCAGAGACTTGGGATGGGAAGAACAGTCGGCTCCCAGTGTGGTCATGAGCAAGTTTTCTGTGGACTGTTCCCCCCACTGTGGTAG
GACAGGACTGGCCCACTTAGTCCTCAAGCTCCCAACCTGCTGTCCCTCAAGCCCCGCTTCTACCAGCCTGTGGAGTTCAGGAGGCGAGAC
ATCCTGGCCTCCTTTGAGAACTGATGGGATCTACCCCCTGTCCACGCGGGACAGTTTCTCAGAACTGGTTCATAGACCACCTGTGTCACC
AACAGCCAGATACCTAATCCCTGAGCCTCCTTTGGGAAGGTCTGGGGCCGAGGGTCTGGGAATTTTTTTTTTTTTTTTTTTTTGGGACAG
AGTCTCATTCTGTCACTCAGGCTAGAGTGCAGTGGCATGATCTTGGCTCACTGCAAGCTCCACCTCCTGGGTTCAAGCGATTCTCTTGCC
TCAGCCTCCTGAGTAGCTGGGACTACATGCGCACACCACCACGTCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTT
GGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCCGCCTTAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCG
GCCCAGGACTTTTAAAACAAGCATCCCAGGGGATTCCGGTGCCTACCAGAAGTCGCAAGCTGCTTGGCTCTGGAGGGCGCCTAGGAGTCG
GTGTCGCCTAAGATGGGATAATGGCTTCAGGCAACTCCTAGCCTTCCCCATATCTCCTGCCTCAGCCCCCCTGGCCCAGTGCTGGGGCGT
CAGCTAAACCTGAGCTTCCAAGAAGTCAGGTTGCCAAAGGAAGGAGCCTTCTGAGACCCTCCCCAACCCACCCAGGTTCCCAAGGCCCTG
CCGTACCCTGGGGAATCAACCAAGGAGTTCTTGTTCTCGAAGAACCCCAGGCCTCATGATGGTCTACGGTAGAGGTCCAACAACTACAGC

>In-frame_KDM2B_ENST00000377071_chr12_121932382_-_RHOF_ENST00000267205_chr12_122231145_-_4045nt
AAAAGTTAGGCAGTCCTTATAGGTATGGAAGCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAAT
GGGGGGATCTGCAGAGGATCACCCCCCACGAAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGA
ATTTGAGTCGGCCACACAGCGCCCGATTGACCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCG
CGGCTTCAGCCTGGAGGAGAAGCTTCGCAGCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGATTTCAACTATGAGTA
CGTACAGAGAGAAGCTCTCAGGGTTCCCCTGATATTTCGAGAAAAGGATGGACTGGGAATTAAGATGCCTGACCCTGATTTCACAGTCCG
AGACGTCAAACTCCTAGTGGGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTT
TGTGCGTTACTACGAGACGCCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTT
GGTCAAGCGTCCGACTGTGGTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAA
CGCCATTGCAGAGATGAAGTACCCGAAAGTGAAAAAGTACTGTCTGATGAGCGTGAAAGGTTGTTTCACCGACTTCCACATCGACTTTGG
AGGCACTTCCGTTTGGTACCATGTTTTCCGGGGTGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAATTTGGCGCTGTACGAGGA
GTGGGTGCTGTCAGGCAAACAGAGTGACATCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTGAAGCAGGGCTACACATT
TTTCATCCCTTCCGGTTGGATCCATGCCGTCTACACCCCTGTAGACTCTTTGGTGTTCGGCGGAAACATCCTGCACAGCTTTAACGTGCC
CATGCAGCTGCGGATCTACGAGATCGAGGACAGGACGCGGGTGCAGCCCAAATTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGT
CCTGGAGAGATACGTGTACTGTGTGACCCAGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTTATTGATGCCCCGAGGAA
GCCCAGCATAGACGGCTTCTCTTCGGATTCCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAGGAGGAGGAGGAGAAGGA
CGAGGAGGGCGAGGGCAGGGACAGGGCACCCAAACCGCCCACCGATGGCTCCACTTCACCCACCAGCACGCCCTCTGAGGACCAGGAGGC
CCTCGGGAAGAAGCCCAAAGCACCTGCCCTGCGATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGTGTGAAGTCCACCACATT
GGCCGTAGACTACCCCAAGACCCCCACCGGCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACTGAGTTTGAACTGAAGGG
CCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGGCATCGAGGACCCCCAGGCACTCCTGGA
GGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCTAGTCTGGCCATCACTGGGGTCCCTGTGGTGACTTGGCCAAAGAAGAC
TCCAAAGCACTACGCCCCATCGGTGTTCGAGAAGTACACGGCCAGCGTGACCGTTGGCAGCAAGGAGGTGACCCTGAACCTCTACGACAC
GGCCGGGCAAGAAGACTATGACCGGCTGCGGCCCCTGTCCTACCAGAACACCCACCTCGTGCTCATCTGCTATGACGTCATGAATCCCAC
CAGCTACGACAACGTCCTCATCAAGTGGTTCCCTGAGGTCACGCATTTCTGCCGCGGGATCCCCATGGTGCTCATCGGCTGCAAGACAGA
CCTGAGGAAGGACAAGGAGCAGCTGCGGAAGCTCCGGGCCGCCCAGCTGGAGCCCATCACCTACATGCAGGGCCTGAGCGCCTGCGAACA
GATCCGAGCTGCTCTCTACCTGGAATGTTCCGCCAAGTTTCGGGAGAATGTGGAGGACGTCTTCCGGGAGGCCGCCAAGGTGGCTCTCAG
CGCTCTGAAGAAGGCGCAACGGCAGAAGAAGCGCCGGCTCTGCCTGCTGCTCTGACCCAGGGCAGACAGACCTCACGACAGCACTGACAG
GGCCCGGGGGCCCAGGTGCCGATTGCACCAGGGAGGCTGCCCCATCCCGACCCTCCAGCTCATGGTGTCTGGGGCCTGCGGCTAGACTCT
TGGAACATTCTGGAACTCTCTCCTTTCCTGGCTGGGGCTCTGACCACAAACTCCCCTCCAGGCTGCCCCTGGGACATGGTGGTGATGTGG
GTGCAGGAGCCAGTGTCTGTTGTCGGGACTCGCAAGTGCCCTCATCACAGCCACCCCCACCACGAGTGTCTCCCCAGTGCAGACTCAAGT
TATGCTTGAAATGAAAAAGTCTATCTGGTAGTGGGTAAACGTAGACCTGGCACTGTTCCACGCGGGCGCCCCAAGCCTGCCACTCCTGTG
TCCCTGCCTCCCTGGGCTCCCGAGATAGGCACCACTGTATCCTCCAGCTCCTTCCTTCCTTCCCCCAGGAACACGGAGGCCACCGAGGGG
GCTGGGCCTATCAGGAGGACACAGGCTGCAGCCTGGCACCCACCCCTCCCATCTCCACCCCACATGGAAGACTTGTCTTCAACTTGGCCA
CTGTCTTTGCAGAGCTGGGCACATGTGCCCAGGGGGCAGAAAAAATGGCTTCTCAGTTGTTAAAAGTATACCCTGGACCACCCATCTGAC
CATCTCCTTAAGGTTTCACCCAAAGCCCCCAGTGTCAGAGACTTGGGATGGGAAGAACAGTCGGCTCCCAGTGTGGTCATGAGCAAGTTT
TCTGTGGACTGTTCCCCCCACTGTGGTAGGACAGGACTGGCCCACTTAGTCCTCAAGCTCCCAACCTGCTGTCCCTCAAGCCCCGCTTCT
ACCAGCCTGTGGAGTTCAGGAGGCGAGACATCCTGGCCTCCTTTGAGAACTGATGGGATCTACCCCCTGTCCACGCGGGACAGTTTCTCA
GAACTGGTTCATAGACCACCTGTGTCACCAACAGCCAGATACCTAATCCCTGAGCCTCCTTTGGGAAGGTCTGGGGCCGAGGGTCTGGGA
ATTTTTTTTTTTTTTTTTTTTTGGGACAGAGTCTCATTCTGTCACTCAGGCTAGAGTGCAGTGGCATGATCTTGGCTCACTGCAAGCTCC
ACCTCCTGGGTTCAAGCGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGGGACTACATGCGCACACCACCACGTCCGGCTAATTTTTGTAT
TTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCCGCCTTAGCCTCCCAAAGTGCT
GGGATTACAGGCGTGAGCCACCGTGCCCGGCCCAGGACTTTTAAAACAAGCATCCCAGGGGATTCCGGTGCCTACCAGAAGTCGCAAGCT
GCTTGGCTCTGGAGGGCGCCTAGGAGTCGGTGTCGCCTAAGATGGGATAATGGCTTCAGGCAACTCCTAGCCTTCCCCATATCTCCTGCC
TCAGCCCCCCTGGCCCAGTGCTGGGGCGTCAGCTAAACCTGAGCTTCCAAGAAGTCAGGTTGCCAAAGGAAGGAGCCTTCTGAGACCCTC
CCCAACCCACCCAGGTTCCCAAGGCCCTGCCGTACCCTGGGGAATCAACCAAGGAGTTCTTGTTCTCGAAGAACCCCAGGCCTCATGATG


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FusionGenePPI for KDM2B_RHOF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM2BBCOR, PCGF1, SKP1, EZH2, CEBPE, LZTR1, JUN, CUL1, SIN3A, PCGF3, RNF2, RYBP, YAF2, HIST1H3A, KIAA0368, KDM2B, UBE2D1, ACBD3, RBX1, FOS, NANOG, POU5F1, TRIM25RHOFELAVL1, ENO1, MOV10, NXF1, ANKFY1, XPO1, RALA, GAR1, NAA25, RAP1GDS1, CCT6B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM2B_RHOF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM2B_RHOF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM2BC0036341Schizophrenia1CTD_human