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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18409

FusionGeneSummary for KDM2A_PPP6R3

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2A_PPP6R3
Fusion gene ID: 18409
HgeneTgene
Gene symbol

KDM2A

PPP6R3

Gene ID

22992

55291

Gene namelysine demethylase 2Aprotein phosphatase 6 regulatory subunit 3
SynonymsCXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINAC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing hserine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL
Modification date2018051920180520
UniProtAcc

Q9Y2K7

Q5H9R7

Ensembl transtripts involved in fusion geneENST00000398645, ENST00000529006, 
ENST00000526258, ENST00000308783, 
ENST00000530342, 
ENST00000393799, 
ENST00000530427, ENST00000393800, 
ENST00000534534, ENST00000524845, 
ENST00000265637, ENST00000524904, 
ENST00000393801, ENST00000265636, 
ENST00000529710, ENST00000527403, 
Fusion gene scores* DoF score24 X 12 X 14=403215 X 15 X 6=1350
# samples 3119
** MAII scorelog2(31/4032*10)=-3.70115551822568
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/1350*10)=-2.82888808360725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM2A [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A0J3-01AKDM2Achr11

66888829

+PPP6R3chr11

68363565

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000398645ENST00000393799KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000530427KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000393800KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000534534KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000524845KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000265637KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000524904KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000393801KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000265636KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000529710KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000398645ENST00000527403KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
Frame-shitENST00000529006ENST00000393799KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000530427KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000393800KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000534534KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000524845KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000265637KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000524904KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000393801KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000265636KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000529710KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
5CDS-intronENST00000529006ENST00000527403KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-3CDSENST00000526258ENST00000393799KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000530427KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000393800KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000534534KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000524845KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000265637KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000524904KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000393801KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000265636KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000529710KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000526258ENST00000527403KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-3CDSENST00000308783ENST00000393799KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000530427KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000393800KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000534534KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000524845KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000265637KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000524904KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000393801KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000265636KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000529710KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000308783ENST00000527403KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-3CDSENST00000530342ENST00000393799KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000530427KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000393800KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000534534KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000524845KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000265637KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000524904KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000393801KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000265636KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000529710KDM2Achr11

66888829

+PPP6R3chr11

68363565

+
intron-intronENST00000530342ENST00000527403KDM2Achr11

66888829

+PPP6R3chr11

68363565

+

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FusionProtFeatures for KDM2A_PPP6R3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2A

Q9Y2K7

PPP6R3

Q5H9R7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM2A_PPP6R3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM2A_PPP6R3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM2ARELA, FOS, BCL6, ELAVL1, KIAA0368, HIST2H3C, SKP1, HIST3H3, SMAD7, SMAD3, ZNF512B, MPG, UBE2G2, RB1, E2F1, EED, ACTR1B, ARHGEF7, PSMB3, RANGAP1, PPP1R2, STAG2, KRAS, HIST1H2BG, RAB5C, REEP5, CBX4, KIF20B, RBPJ, ATM, CGB2, TRIM25, UHRF2PPP6R3KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM2A_PPP6R3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM2A_PPP6R3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource