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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18403

FusionGeneSummary for KDM2A_GSTP1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2A_GSTP1
Fusion gene ID: 18403
HgeneTgene
Gene symbol

KDM2A

GSTP1

Gene ID

22992

2950

Gene namelysine demethylase 2Aglutathione S-transferase pi 1
SynonymsCXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINADFN7|FAEES3|GST3|GSTP|HEL-S-22|PI
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing hglutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III
Modification date2018051920180527
UniProtAcc

Q9Y2K7

P09211

Ensembl transtripts involved in fusion geneENST00000398645, ENST00000529006, 
ENST00000526258, ENST00000308783, 
ENST00000530342, 		ENST00000398606, 
ENST00000398603, ENST00000498765, 
Fusion gene scores* DoF score24 X 12 X 14=40323 X 2 X 3=18
# samples 313
** MAII scorelog2(31/4032*10)=-3.70115551822568
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KDM2A [Title/Abstract] AND GSTP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTP1

GO:0006469

negative regulation of protein kinase activity

16636664

TgeneGSTP1

GO:0006749

glutathione metabolic process

1540159

TgeneGSTP1

GO:0006805

xenobiotic metabolic process

1540159

TgeneGSTP1

GO:0009890

negative regulation of biosynthetic process

18962899

TgeneGSTP1

GO:0032691

negative regulation of interleukin-1 beta production

18962899

TgeneGSTP1

GO:0032720

negative regulation of tumor necrosis factor production

18962899

TgeneGSTP1

GO:0043407

negative regulation of MAP kinase activity

11408560

TgeneGSTP1

GO:0043508

negative regulation of JUN kinase activity

16636664

TgeneGSTP1

GO:0043651

linoleic acid metabolic process

16624487

TgeneGSTP1

GO:0051771

negative regulation of nitric-oxide synthase biosynthetic process

18962899

TgeneGSTP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11408560

TgeneGSTP1

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18962899

TgeneGSTP1

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

16636664


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GV-A3QK-01BKDM2Achr11

66888829

+GSTP1chr11

67351605

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398645ENST00000398606KDM2Achr11

66888829

+GSTP1chr11

67351605

+
Frame-shiftENST00000398645ENST00000398603KDM2Achr11

66888829

+GSTP1chr11

67351605

+
5CDS-intronENST00000398645ENST00000498765KDM2Achr11

66888829

+GSTP1chr11

67351605

+
Frame-shiftENST00000529006ENST00000398606KDM2Achr11

66888829

+GSTP1chr11

67351605

+
Frame-shiftENST00000529006ENST00000398603KDM2Achr11

66888829

+GSTP1chr11

67351605

+
5CDS-intronENST00000529006ENST00000498765KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000526258ENST00000398606KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000526258ENST00000398603KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-intronENST00000526258ENST00000498765KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000308783ENST00000398606KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000308783ENST00000398603KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-intronENST00000308783ENST00000498765KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000530342ENST00000398606KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-3CDSENST00000530342ENST00000398603KDM2Achr11

66888829

+GSTP1chr11

67351605

+
intron-intronENST00000530342ENST00000498765KDM2Achr11

66888829

+GSTP1chr11

67351605

+

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FusionProtFeatures for KDM2A_GSTP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2A

Q9Y2K7

GSTP1

P09211

Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles. Regulatesnegatively CDK5 activity via p25/p35 translocation to preventneurodegeneration. {ECO:0000269|PubMed:21668448}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM2A_GSTP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM2A_GSTP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM2ARELA, FOS, BCL6, ELAVL1, KIAA0368, HIST2H3C, SKP1, HIST3H3, SMAD7, SMAD3, ZNF512B, MPG, UBE2G2, RB1, E2F1, EED, ACTR1B, ARHGEF7, PSMB3, RANGAP1, PPP1R2, STAG2, KRAS, HIST1H2BG, RAB5C, REEP5, CBX4, KIF20B, RBPJ, ATM, CGB2, TRIM25, UHRF2GSTP1FANCC, TGM2, PNO1, PTN, GSTP1, MAPK8, SIRT7, ISG15, CUL3, CUL2, CDK2, COPS5, TRAF2, MAPK1, MAP3K1, ACTA2, LIG4, FN1, VCAM1, ATF2, MLH1, ITGA4, SCAF1, FUS, KRT31, APPBP2, KRTAP10-7, KRTAP10-9, KRTAP10-3, NOTCH2NL, CUL7, HNRNPA1, NTRK1, GSTT2, GSTT2B, ACY1, GABPB1, ZNF518A, TXNL4A, RBMX, UBE2O, FOXD4, FBXL12, MCM2, PRDX6, EGFR, DLD, DLST, SOD1, UBE2A, DCAF4L2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM2A_GSTP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTP1P09211DB00316AcetaminophenGlutathione S-transferase Psmall moleculeapproved
TgeneGSTP1P09211DB00363ClozapineGlutathione S-transferase Psmall moleculeapproved
TgeneGSTP1P09211DB01015SulfamethoxazoleGlutathione S-transferase Psmall moleculeapproved
TgeneGSTP1P09211DB00903Etacrynic acidGlutathione S-transferase Psmall moleculeapproved|investigational
TgeneGSTP1P09211DB04339CarbocisteineGlutathione S-transferase Psmall moleculeapproved|investigational
TgeneGSTP1P09211DB09462GlycerinGlutathione S-transferase Psmall moleculeapproved|investigational
TgeneGSTP1P09211DB00143GlutathioneGlutathione S-transferase Psmall moleculeapproved|investigational|nutraceutical
TgeneGSTP1P09211DB01242ClomipramineGlutathione S-transferase Psmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for KDM2A_GSTP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSTP1C0032927Precancerous Conditions5CTD_human
TgeneGSTP1C0033578Prostatic Neoplasms5CTD_human
TgeneGSTP1C0023904Liver Neoplasms, Experimental4CTD_human
TgeneGSTP1C0004096Asthma3CTD_human
TgeneGSTP1C0005695Bladder Neoplasm3CTD_human
TgeneGSTP1C0030567Parkinson Disease2CTD_human
TgeneGSTP1C0036341Schizophrenia2PSYGENET
TgeneGSTP1C0038356Stomach Neoplasms2CTD_human
TgeneGSTP1C4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneGSTP1C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneGSTP1C0004352Autistic Disorder1CTD_human
TgeneGSTP1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneGSTP1C0007134Renal Cell Carcinoma1CTD_human
TgeneGSTP1C0007273Carotid Artery Diseases1CTD_human
TgeneGSTP1C0008625Chromosome Aberrations1CTD_human
TgeneGSTP1C0011616Contact Dermatitis1CTD_human
TgeneGSTP1C0013182Drug Allergy1CTD_human
TgeneGSTP1C0017638Glioma1CTD_human
TgeneGSTP1C0019829Hodgkin Disease1CTD_human
TgeneGSTP1C0022650Kidney Calculi1CTD_human
TgeneGSTP1C0022658Kidney Diseases1CTD_human
TgeneGSTP1C0023473Myeloid Leukemia, Chronic1CTD_human
TgeneGSTP1C0024121Lung Neoplasms1CTD_human
TgeneGSTP1C0027540Necrosis1CTD_human
TgeneGSTP1C0029463Osteosarcoma1CTD_human
TgeneGSTP1C0031117Peripheral Neuropathy1CTD_human
TgeneGSTP1C0033941Psychoses, Substance-Induced1CTD_human
TgeneGSTP1C0033975Psychotic Disorders1PSYGENET
TgeneGSTP1C0035234Respiratory Sounds1CTD_human
TgeneGSTP1C0036939Shared Paranoid Disorder1PSYGENET
TgeneGSTP1C0042594Vestibular Diseases1CTD_human
TgeneGSTP1C0151744Myocardial Ischemia1CTD_human
TgeneGSTP1C0236733Amphetamine-Related Disorders1CTD_human
TgeneGSTP1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneGSTP1C0349204Nonorganic psychosis1PSYGENET
TgeneGSTP1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneGSTP1C0600427Cocaine Dependence1PSYGENET
TgeneGSTP1C0948089Acute Coronary Syndrome1CTD_human
TgeneGSTP1C1261473Sarcoma1CTD_human
TgeneGSTP1C1456865Ureteral Calculi1CTD_human
TgeneGSTP1C1458155Mammary Neoplasms1CTD_human
TgeneGSTP1C2239176Liver carcinoma1CTD_human
TgeneGSTP1C2609414Acute kidney injury1CTD_human