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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18392

FusionGeneSummary for KDM1B_DENR

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM1B_DENR
Fusion gene ID: 18392
HgeneTgene
Gene symbol

KDM1B

DENR

Gene ID

221656

8562

Gene namelysine demethylase 1Bdensity regulated re-initiation and release factor
SynonymsAOF1|C6orf193|LSD2|bA204B7.3|dJ298J15.2DRP|DRP1|SMAP-3
Cytomap

6p22.3

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific histone demethylase 1Bamine oxidase (flavin containing) domain 1amine oxidase, flavin containing 1flavin-containing amine oxidase domain-containing protein 1lysine (K)-specific demethylase 1Blysine-specific histone demethylase 2density-regulated proteinsmooth muscle cell associated protein-3
Modification date2018052320180523
UniProtAcc

Q8NB78

O43583

Ensembl transtripts involved in fusion geneENST00000546309, ENST00000397244, 
ENST00000388870, ENST00000297792, 
ENST00000280557, ENST00000455982, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 5 X 3=90
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM1B [Title/Abstract] AND DENR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM1B

GO:0034720

histone H3-K4 demethylation

23266887

TgeneDENR

GO:0001731

formation of translation preinitiation complex

20713520

TgeneDENR

GO:0032790

ribosome disassembly

20713520

TgeneDENR

GO:0075522

IRES-dependent viral translational initiation

20713520


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC012148KDM1Bchr6

18205966

+DENRchr12

123254301

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000546309ENST00000280557KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000546309ENST00000455982KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000397244ENST00000280557KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000397244ENST00000455982KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000388870ENST00000280557KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000388870ENST00000455982KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000297792ENST00000280557KDM1Bchr6

18205966

+DENRchr12

123254301

+
intron-3UTRENST00000297792ENST00000455982KDM1Bchr6

18205966

+DENRchr12

123254301

+

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FusionProtFeatures for KDM1B_DENR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM1B

Q8NB78

DENR

O43583

Histone demethylase that demethylates 'Lys-4' of histoneH3, a specific tag for epigenetic transcriptional activation,thereby acting as a corepressor. Required for de novo DNAmethylation of a subset of imprinted genes during oogenesis. Actsby oxidizing the substrate by FAD to generate the correspondingimine that is subsequently hydrolyzed. Demethylates both mono- anddi-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-,di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' ofhistone H4. {ECO:0000269|PubMed:23260659,ECO:0000269|PubMed:23357850}. May be involved in the translation of target mRNAs byscanning and recognition of the initiation codon. Involved intranslation initiation; promotes recruitmnet of aminoacetyledinitiator tRNA to P site of 40S ribosomes. Can promote release ofdeacylated tRNA and mRNA from recycled 40S subunits followingABCE1-mediated dissociation of post-termination ribosomalcomplexes into subunits. Plays a role in the modulation of thetranslational profile of a subset of cancer-related mRNAs whenrecruited to the translational initiation complex by the oncogeneMCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526,ECO:0000269|PubMed:20713520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KDM1B_DENR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KDM1B_DENR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM1B_DENR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM1B_DENR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource