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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18367

FusionGeneSummary for KCTD21_KCTD21

check button Fusion gene summary
Fusion gene informationFusion gene name: KCTD21_KCTD21
Fusion gene ID: 18367
HgeneTgene
Gene symbol

KCTD21

KCTD21

Gene ID

283219

283219

Gene namepotassium channel tetramerization domain containing 21potassium channel tetramerization domain containing 21
SynonymsKCASH2KCASH2
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein KCTD21potassium channel tetramerisation domain containing 21potassium channel tetramerization domain-containing protein 21BTB/POZ domain-containing protein KCTD21potassium channel tetramerisation domain containing 21potassium channel tetramerization domain-containing protein 21
Modification date2018051920180519
UniProtAcc

Q4G0X4

Q4G0X4

Ensembl transtripts involved in fusion geneENST00000340067, ENST00000340067, 
Fusion gene scores* DoF score4 X 2 X 4=325 X 2 X 3=30
# samples 56
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCTD21 [Title/Abstract] AND KCTD21 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCTD21

GO:0006511

ubiquitin-dependent protein catabolic process

21472142

HgeneKCTD21

GO:0045879

negative regulation of smoothened signaling pathway

21472142

TgeneKCTD21

GO:0006511

ubiquitin-dependent protein catabolic process

21472142

TgeneKCTD21

GO:0045879

negative regulation of smoothened signaling pathway

21472142


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N28979KCTD21chr11

77882659

+KCTD21chr11

77882622

-
ChiTaRS3.1BX114694KCTD21chr11

77882659

+KCTD21chr11

77882622

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000340067ENST00000340067KCTD21chr11

77882659

+KCTD21chr11

77882622

-

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FusionProtFeatures for KCTD21_KCTD21


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCTD21

Q4G0X4

KCTD21

Q4G0X4

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating theubiquitination and subsequent proteasomal degradation of targetproteins. Promotes the ubiquitination of HDAC1. Can function asantagonist of the Hedgehog pathway by affecting the nucleartransfer of transcription factor GLI1; the function probablyoccurs via HDAC1 down-regulation, keeping GLI1 acetylated andinactive. Inhibits cell growth and tumorigenicity ofmedulloblastoma (MDB) (PubMed:21472142).{ECO:0000269|PubMed:21472142}. Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating theubiquitination and subsequent proteasomal degradation of targetproteins. Promotes the ubiquitination of HDAC1. Can function asantagonist of the Hedgehog pathway by affecting the nucleartransfer of transcription factor GLI1; the function probablyoccurs via HDAC1 down-regulation, keeping GLI1 acetylated andinactive. Inhibits cell growth and tumorigenicity ofmedulloblastoma (MDB) (PubMed:21472142).{ECO:0000269|PubMed:21472142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCTD21_KCTD21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCTD21_KCTD21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCTD21_KCTD21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCTD21_KCTD21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource