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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18360

FusionGeneSummary for KCTD20_BRPF3

check button Fusion gene summary
Fusion gene informationFusion gene name: KCTD20_BRPF3
Fusion gene ID: 18360
HgeneTgene
Gene symbol

KCTD20

BRPF3

Gene ID

222658

27154

Gene namepotassium channel tetramerization domain containing 20bromodomain and PHD finger containing 3
SynonymsC6orf69|dJ108K11.3-
Cytomap

6p21.31

6p21.31

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein KCTD20potassium channel tetramerisation domain containing 20bromodomain and PHD finger-containing protein 3
Modification date2018051920180519
UniProtAcc

Q7Z5Y7

Q9ULD4

Ensembl transtripts involved in fusion geneENST00000373731, ENST00000474988, 
ENST00000544295, ENST00000449081, 
ENST00000536244, 
ENST00000357641, 
ENST00000339717, ENST00000534694, 
ENST00000543502, ENST00000443324, 
ENST00000534400, 
Fusion gene scores* DoF score7 X 2 X 7=983 X 3 X 2=18
# samples 73
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCTD20 [Title/Abstract] AND BRPF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRPF3

GO:0043966

histone H3 acetylation

16387653


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A91N-01AKCTD20chr6

36410888

+BRPF3chr6

36168074

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000373731ENST00000357641KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000373731ENST00000339717KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000373731ENST00000534694KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000373731ENST00000543502KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000373731ENST00000443324KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000373731ENST00000534400KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000357641KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000339717KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000534694KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000543502KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000443324KCTD20chr6

36410888

+BRPF3chr6

36168074

+
3UTR-5UTRENST00000474988ENST00000534400KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000357641KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000339717KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000534694KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000543502KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000443324KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000544295ENST00000534400KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000357641KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000339717KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000534694KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000543502KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000443324KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000449081ENST00000534400KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000357641KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000339717KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000534694KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000543502KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000443324KCTD20chr6

36410888

+BRPF3chr6

36168074

+
5UTR-5UTRENST00000536244ENST00000534400KCTD20chr6

36410888

+BRPF3chr6

36168074

+

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FusionProtFeatures for KCTD20_BRPF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCTD20

Q7Z5Y7

BRPF3

Q9ULD4

Promotes the phosphorylation of AKT family members.{ECO:0000250|UniProtKB:Q8CDD8}. Component of the MOZ/MORF complex which has a histone H3acetyltransferase activity. {ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCTD20_BRPF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCTD20_BRPF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KCTD20MARK4, PPP1CA, CUL3, PPP1CC, BUB3, XPO1, COPS7A, DUSP16, TRIM25BRPF3ING5, ELAVL1, WEE1, MEAF6, KAT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCTD20_BRPF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCTD20_BRPF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource