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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1836

FusionGeneSummary for ANKRD28_RFTN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD28_RFTN1
Fusion gene ID: 1836
HgeneTgene
Gene symbol

ANKRD28

RFTN1

Gene ID

23243

23180

Gene nameankyrin repeat domain 28raftlin, lipid raft linker 1
SynonymsPITK|PPP1R65MIG2|PIB10|PIG9|RAFTLIN
Cytomap

3p25.1

3p24.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory raftlincell migration-inducing gene 2 proteinproliferation-inducing protein 10proliferation-inducing protein 9raft-linking protein
Modification date2018051920180519
UniProtAcc

O15084

Q14699

Ensembl transtripts involved in fusion geneENST00000383777, ENST00000399451, 
ENST00000497037, 
ENST00000432519, 
ENST00000334133, ENST00000483671, 
Fusion gene scores* DoF score11 X 10 X 10=11003 X 3 X 3=27
# samples 123
** MAII scorelog2(12/1100*10)=-3.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD28 [Title/Abstract] AND RFTN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-18-3414-01AANKRD28chr3

15719716

-RFTN1chr3

16535384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000383777ENST00000432519ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5CDS-5UTRENST00000383777ENST00000334133ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5CDS-intronENST00000383777ENST00000483671ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5CDS-intronENST00000399451ENST00000432519ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5CDS-5UTRENST00000399451ENST00000334133ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5CDS-intronENST00000399451ENST00000483671ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5UTR-intronENST00000497037ENST00000432519ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5UTR-5UTRENST00000497037ENST00000334133ANKRD28chr3

15719716

-RFTN1chr3

16535384

-
5UTR-intronENST00000497037ENST00000483671ANKRD28chr3

15719716

-RFTN1chr3

16535384

-

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FusionProtFeatures for ANKRD28_RFTN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD28

O15084

RFTN1

Q14699

Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. Involved in the PP6-mediated dephosphorylation ofNFKBIE opposing its degradation in response to TNF-alpha.Selectively inhibits the phosphatase activity of PPP1C. TargetsPPP1C to modulate HNRPK phosphorylation.{ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}. Involved in protein trafficking via association withclathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Uponbacterial lipopolysaccharide stimulation, mediates internalizationof TLR4 to endosomes in dendritic cells and macrophages; andinternalization of poly(I:C) to TLR3-positive endosomes in myeloiddendritic cells and epithelial cells; resulting in activation ofTICAM1-mediated signaling and subsequent IFNB1 production(PubMed:27022195, PubMed:21266579). Involved in T-cell antigenreceptor-mediated signaling by regulating tyrosine kinase LCKlocalization, T-cell dependent antibody production and cytokinesecretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role inthe formation and/or maintenance of lipid rafts (PubMed:12805216).{ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216,ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD28_RFTN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD28_RFTN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD28TBK1, USP21, USP49, PLK1, PPP6C, SIRT7, AP2M1, BRCA1, ZNF512B, TGM2, CSNK2B, AGPAT2, FBXO6, USP10, ACACB, AKAP8L, ANKRD44, APC, ARHGEF2, CEP192, DNAJB1, EPS8, FAM175B, FAM193A, FBF1, HECTD1, CEP162, KRI1, MAGED1, MTMR3, NEK4, NFATC4, NOTCH2, PLEKHG1, PPP1R9A, PPP1R9B, PPP6R1, PPP6R2, PPP6R3, RAD21, RASSF8, RCN2, SDCCAG3, SEC16A, SHKBP1, SMC1A, SMC3, SNX18, TBKBP1, TRIM41, UBR5, MOB1A, MOB1B, CTTNBP2NL, FLNC, LEO1, HOXC4, NECAP2, SDCBP, FOXD4L6, DCLRE1C, PLK2, NTRK1, CEP128, CEP44, CNTRL, ODF2, RPGRIP1L, CEP19, LCA5, XRCC6, FOXK1, FOXK2, ZNRF2, ZNF574, TRMT2A, ZNF785, CIRH1A, CAMK4, CDKL1, MRPS7, DFNB31, TRIM25RFTN1SLC25A41, UNC119, MUS81, PTEN, CTDSPL, RABGAP1L, TGM5, ATG2A, SDC1, GJB7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD28_RFTN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD28_RFTN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource