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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18349

FusionGeneSummary for KCTD10_GLTP

check button Fusion gene summary
Fusion gene informationFusion gene name: KCTD10_GLTP
Fusion gene ID: 18349
HgeneTgene
Gene symbol

KCTD10

GLTP

Gene ID

83892

51228

Gene namepotassium channel tetramerization domain containing 10glycolipid transfer protein
SynonymsBTBD28|MSTP028|ULRO61|hBACURD3-
Cytomap

12q24.11

12q24.11

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3BTB/POZ domain-containing protein KCTD10potassium channel tetramerisation domain containing 10potassium channel tetramerization domain-containing protein 10glycolipid transfer proteintruncated glycolipid transfer protein
Modification date2018051920180523
UniProtAcc

Q9H3F6

Q9NZD2

Ensembl transtripts involved in fusion geneENST00000228495, ENST00000540089, 
ENST00000424763, ENST00000538161, 
ENST00000540411, 
ENST00000318348, 
ENST00000544393, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KCTD10 [Title/Abstract] AND GLTP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCTD10

GO:0006511

ubiquitin-dependent protein catabolic process

25401743

TgeneGLTP

GO:0120009

intermembrane lipid transfer

15901739


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8060-01AKCTD10chr12

109895797

-GLTPchr12

110296546

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000228495ENST00000318348KCTD10chr12

109895797

-GLTPchr12

110296546

-
Frame-shiftENST00000228495ENST00000544393KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000540089ENST00000318348KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000540089ENST00000544393KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000424763ENST00000318348KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000424763ENST00000544393KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000538161ENST00000318348KCTD10chr12

109895797

-GLTPchr12

110296546

-
5UTR-3CDSENST00000538161ENST00000544393KCTD10chr12

109895797

-GLTPchr12

110296546

-
Frame-shiftENST00000540411ENST00000318348KCTD10chr12

109895797

-GLTPchr12

110296546

-
Frame-shiftENST00000540411ENST00000544393KCTD10chr12

109895797

-GLTPchr12

110296546

-

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FusionProtFeatures for KCTD10_GLTP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCTD10

Q9H3F6

GLTP

Q9NZD2

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitinligase complex mediates the ubiquitination of target proteins,leading to their degradation by the proteasome (By similarity).{ECO:0000250|UniProtKB:Q8WZ19}. Accelerates the intermembrane transfer of variousglycolipids. Catalyzes the transfer of various glycosphingolipidsbetween membranes but does not catalyze the transfer ofphospholipids. May be involved in the intracellular translocationof glucosylceramides. {ECO:0000269|PubMed:15329726,ECO:0000269|PubMed:15504043, ECO:0000269|PubMed:17980653,ECO:0000269|PubMed:18261224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCTD10_GLTP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCTD10_GLTP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KCTD10ATXN3, USP13, USP25, KCTD13, UBC, ITSN2, SH3KBP1, TNFAIP1, CUL3, COPS5, COPS6, DCUN1D1, NEDD8, PCNA, FMNL1, RNF2, UBXN1, EPN3, ADAP2, CAPZA2, DBN1, FLNA, MYO1C, XRCC3, LIMA1, MYO18A, UBXN7, FAF1, ARIH1, RAD23B, TNFAIP3, LMO2, EXOSC1, CFAP36, GLMN, KIR3DL2, NRP1, RABGEF1, CEP76, SOST, PPP1R21, ODF3L2, AGRP, MAB21L2, FAM188A, NOTCH1GLTPELAVL1, CMTM5, STARD7, ASPSCR1, SHKBP1, AMD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCTD10_GLTP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCTD10_GLTP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource