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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18332

FusionGeneSummary for KCNQ1_TSPAN32

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNQ1_TSPAN32
Fusion gene ID: 18332
HgeneTgene
Gene symbol

KCNQ1

TSPAN32

Gene ID

3784

10077

Gene namepotassium voltage-gated channel subfamily Q member 1tetraspanin 32
SynonymsATFB1|ATFB3|JLNS1|KCNA8|KCNA9|KVLQT1|Kv1.9|Kv7.1|LQT|LQT1|RWS|SQT2|WRSART1|PHEMX|PHMX|TSSC6
Cytomap

11p15.5-p15.4

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 1IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1kidney and cardiac voltage dependend K+ channelpotassium channel, voltage gated KQT-like subfamily Q, member 1potassium voltagtetraspanin-32pan-hematopoietic expression proteinprotein Phemxtumor-suppressing STF cDNA 6tumor-suppressing subchromosomal transferable fragment cDNA 6tumor-suppressing subtransferable candidate 6
Modification date2018052720180523
UniProtAcc

P51787

Q96QS1

Ensembl transtripts involved in fusion geneENST00000155840, ENST00000335475, 
ENST00000526095, 
ENST00000182290, 
ENST00000483227, ENST00000381121, 
ENST00000451520, 
Fusion gene scores* DoF score12 X 8 X 8=7682 X 2 X 2=8
# samples 122
** MAII scorelog2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KCNQ1 [Title/Abstract] AND TSPAN32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ1

GO:0035690

cellular response to drug

9108097

HgeneKCNQ1

GO:0060306

regulation of membrane repolarization

11299204

HgeneKCNQ1

GO:0071320

cellular response to cAMP

11299204|16002409

HgeneKCNQ1

GO:0071435

potassium ion export

8900283|10400998

HgeneKCNQ1

GO:0071805

potassium ion transmembrane transport

9354802|11299204|16002409

HgeneKCNQ1

GO:0086011

membrane repolarization during action potential

8900283|11299204|19646991

HgeneKCNQ1

GO:0097623

potassium ion export across plasma membrane

17289006

HgeneKCNQ1

GO:1901381

positive regulation of potassium ion transmembrane transport

8900283


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1JG-01BKCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000155840ENST00000182290KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000155840ENST00000483227KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000155840ENST00000381121KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000155840ENST00000451520KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
In-frameENST00000335475ENST00000182290KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000335475ENST00000483227KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000335475ENST00000381121KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
5CDS-3UTRENST00000335475ENST00000451520KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
intron-3CDSENST00000526095ENST00000182290KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
intron-3UTRENST00000526095ENST00000483227KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
intron-3UTRENST00000526095ENST00000381121KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+
intron-3UTRENST00000526095ENST00000451520KCNQ1chr11

2549248

+TSPAN32chr11

2324074

+

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FusionProtFeatures for KCNQ1_TSPAN32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNQ1

P51787

TSPAN32

Q96QS1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216143_147159677Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+2161_121159677Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216122_142159677TransmembraneHelical%3B Name%3DSegment S1
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000182290+010203_22322321TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000182290+01060_8022321TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000182290+01090_11022321TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000381121+09203_22322254TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000381121+0960_8022254TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000381121+0990_11022254TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216585_621159677Coiled coilOntology_term=ECO:0000269
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216585_62132550Coiled coilOntology_term=ECO:0000269
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216300_320159677IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216300_32032550IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216312_317159677MotifSelectivity filter
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216312_31732550MotifSelectivity filter
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216589_620159677RegionC-terminal assembly domain
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216589_62032550RegionC-terminal assembly domain
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216169_196159677Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216218_225159677Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216249_261159677Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216283_299159677Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216321_327159677Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216349_676159677Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216143_14732550Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216169_19632550Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+2161_12132550Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216218_22532550Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216249_26132550Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216283_29932550Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216321_32732550Topological domainExtracellular
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216349_67632550Topological domainCytoplasmic
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216148_168159677TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216197_217159677TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216226_248159677TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216262_282159677TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216328_348159677TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216122_14232550TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216148_16832550TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216197_21732550TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216226_24832550TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216262_28232550TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216328_34832550TransmembraneHelical%3B Name%3DSegment S6
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000182290+01014_3422321TransmembraneHelical
TgeneTSPAN32chr11:2549248chr11:2324074ENST00000381121+0914_3422254TransmembraneHelical


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FusionGeneSequence for KCNQ1_TSPAN32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KCNQ1_ENST00000155840_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_458aa
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPR
VSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMLLGLSVATMVTLTYFGAHFAV
IRRASLEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAAATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQVEDAMLDTYDLVYEQ
AMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAAREDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSFLWFAI
RCGCSLDRKGKYTLTPRACGRQPQEPSLLRCSQGGPTHCLHSEAVAIGPRGCSGSLRWLQESDAAPLPLSCHLAAHRALQGRSRGGLSGC

>In-frame_KCNQ1_ENST00000335475_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_331aa
MDFLIVLVCLIFSVLSTIEQYAALATGTLFWMLLGLSVATMVTLTYFGAHFAVIRRASLEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSA
AATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEA
DLCQGEEAAREDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSFLWFAIRCGCSLDRKGKYTLTPRACGRQPQEPSLLRCSQGGPT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KCNQ1_ENST00000155840_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_1374nt
ATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGGCGGGGCAGCGCGGGCCTG
GCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGCGCCCGGCGCCCCAGGT
CCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCGGTGAGCCTAGACCCGCGC
GTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGAGCGTCCCACCGGCTGG
AAATGCTTCGTTTACCACTTCGCCGTCTTCCTCATCGTCCTGGTCTGCCTCATCTTCAGCGTGCTGTCCACCATCGAGCAGTATGCCGCC
CTGGCCACGGGGACTCTCTTCTGGATGCTGCTGGGCCTCTCTGTGGCCACCATGGTGACTCTTACCTACTTCGGGGCCCACTTTGCTGTC
ATCCGCCGAGCGTCCCTGGAGAAGAACCCGTACCAGGCTGTGCACCAATGGGCCTTCTCTGCGGGGTTGAGCCTGGTGGGCCTCCTGACT
CTGGGAGCCGTGCTGAGCGCTGCAGCCACCGTGAGGGAGGCCCAGGGCCTCATGGCAGGGGGCTTCCTGTGCTTCTCCCTGGCGTTCTGC
GCACAGGTGCAGGTGGTGTTCTGGAGACTCCACAGCCCCACCCAGGTGGAGGACGCCATGCTGGACACCTACGACCTGGTATATGAGCAG
GCGATGAAAGGTACGTCCCACGTCCGGCGGCAGGAGCTGGCGGCCATCCAGGACGTGTTTCTGTGCTGTGGGAAGAAGTCTCCTTTCAGC
CGTCTGGGGAGCACAGAGGCTGACCTGTGTCAGGGAGAGGAGGCGGCGAGAGAGGACTGCCTTCAGGGCATCCGGAGCTTCCTGAGGACA
CACCAGCAGGTCGCCTCCAGCCTGACCAGCATCGGCCTGGCCCTCACGGTGTCCGCCTTGCTCTTCAGCTCCTTCCTGTGGTTTGCCATC
CGCTGTGGCTGCAGCTTGGACCGCAAGGGCAAATACACCCTGACCCCACGAGCATGTGGCCGCCAGCCCCAGGAGCCCAGCCTCTTGAGA
TGCTCCCAGGGTGGACCCACACATTGTCTCCACTCCGAAGCAGTTGCTATTGGTCCAAGAGGATGCTCGGGTAGTCTTCGGTGGCTGCAG
GAGAGCGATGCTGCGCCTCTGCCCCTCTCCTGCCACCTGGCTGCCCACAGAGCTCTCCAGGGCAGAAGTCGCGGTGGGCTCAGTGGGTGC

>In-frame_KCNQ1_ENST00000335475_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_993nt
ATGGACTTCCTCATCGTCCTGGTCTGCCTCATCTTCAGCGTGCTGTCCACCATCGAGCAGTATGCCGCCCTGGCCACGGGGACTCTCTTC
TGGATGCTGCTGGGCCTCTCTGTGGCCACCATGGTGACTCTTACCTACTTCGGGGCCCACTTTGCTGTCATCCGCCGAGCGTCCCTGGAG
AAGAACCCGTACCAGGCTGTGCACCAATGGGCCTTCTCTGCGGGGTTGAGCCTGGTGGGCCTCCTGACTCTGGGAGCCGTGCTGAGCGCT
GCAGCCACCGTGAGGGAGGCCCAGGGCCTCATGGCAGGGGGCTTCCTGTGCTTCTCCCTGGCGTTCTGCGCACAGGTGCAGGTGGTGTTC
TGGAGACTCCACAGCCCCACCCAGGTGGAGGACGCCATGCTGGACACCTACGACCTGGTATATGAGCAGGCGATGAAAGGTACGTCCCAC
GTCCGGCGGCAGGAGCTGGCGGCCATCCAGGACGTGTTTCTGTGCTGTGGGAAGAAGTCTCCTTTCAGCCGTCTGGGGAGCACAGAGGCT
GACCTGTGTCAGGGAGAGGAGGCGGCGAGAGAGGACTGCCTTCAGGGCATCCGGAGCTTCCTGAGGACACACCAGCAGGTCGCCTCCAGC
CTGACCAGCATCGGCCTGGCCCTCACGGTGTCCGCCTTGCTCTTCAGCTCCTTCCTGTGGTTTGCCATCCGCTGTGGCTGCAGCTTGGAC
CGCAAGGGCAAATACACCCTGACCCCACGAGCATGTGGCCGCCAGCCCCAGGAGCCCAGCCTCTTGAGATGCTCCCAGGGTGGACCCACA
CATTGTCTCCACTCCGAAGCAGTTGCTATTGGTCCAAGAGGATGCTCGGGTAGTCTTCGGTGGCTGCAGGAGAGCGATGCTGCGCCTCTG
CCCCTCTCCTGCCACCTGGCTGCCCACAGAGCTCTCCAGGGCAGAAGTCGCGGTGGGCTCAGTGGGTGCCCTGAGCGGGGTCTCTCAGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KCNQ1_ENST00000155840_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_1700nt
GCGGCGGGGCTGGCAGCAGTGGCTGCCCGCACTGCGCCCGGGCGCTCGCCTTCGCTGCAGCTCCCGGTGCCGCCGCTCGGGCCGGCCCCC
CGGCAGGCCCTCCTCGTTATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGG
CGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATC
GCGCCCGGCGCCCCAGGTCCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCG
GTGAGCCTAGACCCGCGCGTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTC
GAGCGTCCCACCGGCTGGAAATGCTTCGTTTACCACTTCGCCGTCTTCCTCATCGTCCTGGTCTGCCTCATCTTCAGCGTGCTGTCCACC
ATCGAGCAGTATGCCGCCCTGGCCACGGGGACTCTCTTCTGGATGCTGCTGGGCCTCTCTGTGGCCACCATGGTGACTCTTACCTACTTC
GGGGCCCACTTTGCTGTCATCCGCCGAGCGTCCCTGGAGAAGAACCCGTACCAGGCTGTGCACCAATGGGCCTTCTCTGCGGGGTTGAGC
CTGGTGGGCCTCCTGACTCTGGGAGCCGTGCTGAGCGCTGCAGCCACCGTGAGGGAGGCCCAGGGCCTCATGGCAGGGGGCTTCCTGTGC
TTCTCCCTGGCGTTCTGCGCACAGGTGCAGGTGGTGTTCTGGAGACTCCACAGCCCCACCCAGGTGGAGGACGCCATGCTGGACACCTAC
GACCTGGTATATGAGCAGGCGATGAAAGGTACGTCCCACGTCCGGCGGCAGGAGCTGGCGGCCATCCAGGACGTGTTTCTGTGCTGTGGG
AAGAAGTCTCCTTTCAGCCGTCTGGGGAGCACAGAGGCTGACCTGTGTCAGGGAGAGGAGGCGGCGAGAGAGGACTGCCTTCAGGGCATC
CGGAGCTTCCTGAGGACACACCAGCAGGTCGCCTCCAGCCTGACCAGCATCGGCCTGGCCCTCACGGTGTCCGCCTTGCTCTTCAGCTCC
TTCCTGTGGTTTGCCATCCGCTGTGGCTGCAGCTTGGACCGCAAGGGCAAATACACCCTGACCCCACGAGCATGTGGCCGCCAGCCCCAG
GAGCCCAGCCTCTTGAGATGCTCCCAGGGTGGACCCACACATTGTCTCCACTCCGAAGCAGTTGCTATTGGTCCAAGAGGATGCTCGGGT
AGTCTTCGGTGGCTGCAGGAGAGCGATGCTGCGCCTCTGCCCCTCTCCTGCCACCTGGCTGCCCACAGAGCTCTCCAGGGCAGAAGTCGC
GGTGGGCTCAGTGGGTGCCCTGAGCGGGGTCTCTCAGACTGACGTCAGGCCTTGGTGGGCTGCACTCTCACCTGGAGGCTCCGGGGAAGC
ATCTGCCTCCAGGACCATTCAGGCTGTTGACAAGTCAACTCCTCATGGCTGTAGGACTGAGGTTCCCAAGTCCTTGTCCCTGGTCCTGTG

>In-frame_KCNQ1_ENST00000335475_chr11_2549248_+_TSPAN32_ENST00000182290_chr11_2324074_+_1485nt
CTCTTCCCTTCCTCCCCTGCAGCTTCCATGGCCTGGGGCTGTGAGAGGCCCGGGAAGGCACTGTCTTTGCGCCTGCACATGTGTGTGTCT
GGAGTGTAGGATGGCACTGGTGCCGGGCCTGGATTTACTCAGCCCAGATCACGGCTGCTTTTGTTTACGTGGCCCCTGCTCTCACCCACA
ACTCCAGGTTTCTGGCTCTCGGGAATTTGAGGCCTGTGGCTGCTGTGGACCCTGGGAAAGAGCCTGTGCTTCCTGAGCCAGTGCGGGGCC
TGGCATGGACTTCCTCATCGTCCTGGTCTGCCTCATCTTCAGCGTGCTGTCCACCATCGAGCAGTATGCCGCCCTGGCCACGGGGACTCT
CTTCTGGATGCTGCTGGGCCTCTCTGTGGCCACCATGGTGACTCTTACCTACTTCGGGGCCCACTTTGCTGTCATCCGCCGAGCGTCCCT
GGAGAAGAACCCGTACCAGGCTGTGCACCAATGGGCCTTCTCTGCGGGGTTGAGCCTGGTGGGCCTCCTGACTCTGGGAGCCGTGCTGAG
CGCTGCAGCCACCGTGAGGGAGGCCCAGGGCCTCATGGCAGGGGGCTTCCTGTGCTTCTCCCTGGCGTTCTGCGCACAGGTGCAGGTGGT
GTTCTGGAGACTCCACAGCCCCACCCAGGTGGAGGACGCCATGCTGGACACCTACGACCTGGTATATGAGCAGGCGATGAAAGGTACGTC
CCACGTCCGGCGGCAGGAGCTGGCGGCCATCCAGGACGTGTTTCTGTGCTGTGGGAAGAAGTCTCCTTTCAGCCGTCTGGGGAGCACAGA
GGCTGACCTGTGTCAGGGAGAGGAGGCGGCGAGAGAGGACTGCCTTCAGGGCATCCGGAGCTTCCTGAGGACACACCAGCAGGTCGCCTC
CAGCCTGACCAGCATCGGCCTGGCCCTCACGGTGTCCGCCTTGCTCTTCAGCTCCTTCCTGTGGTTTGCCATCCGCTGTGGCTGCAGCTT
GGACCGCAAGGGCAAATACACCCTGACCCCACGAGCATGTGGCCGCCAGCCCCAGGAGCCCAGCCTCTTGAGATGCTCCCAGGGTGGACC
CACACATTGTCTCCACTCCGAAGCAGTTGCTATTGGTCCAAGAGGATGCTCGGGTAGTCTTCGGTGGCTGCAGGAGAGCGATGCTGCGCC
TCTGCCCCTCTCCTGCCACCTGGCTGCCCACAGAGCTCTCCAGGGCAGAAGTCGCGGTGGGCTCAGTGGGTGCCCTGAGCGGGGTCTCTC
AGACTGACGTCAGGCCTTGGTGGGCTGCACTCTCACCTGGAGGCTCCGGGGAAGCATCTGCCTCCAGGACCATTCAGGCTGTTGACAAGT
CAACTCCTCATGGCTGTAGGACTGAGGTTCCCAAGTCCTTGTCCCTGGTCCTGTGGTCCCTCCACCTTCAAACCAGCAATGGTGCATTGA


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FusionGenePPI for KCNQ1_TSPAN32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KCNQ1TRAF6, AKAP9, PRKAR2A, PPP1CA, PRKACA, KCNE1, KCNE2, KCNQ2, HSPA4, NEDD4, USP2, AP2M1, NEDD4L, ATP4A, EGFR, BACE1TSPAN32


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216588_616159677AKAP9
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216588_61632550AKAP9
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000155840+216535_572159677KCNE1 C-terminus
HgeneKCNQ1chr11:2549248chr11:2324074ENST00000335475+216535_57232550KCNE1 C-terminus


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCNQ1_TSPAN32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKCNQ1P51787DB00808IndapamidePotassium voltage-gated channel subfamily KQT member 1 {ECO:0000305}small moleculeapproved
HgeneKCNQ1P51787DB11633IsavuconazolePotassium voltage-gated channel subfamily KQT member 1 {ECO:0000305}small moleculeapproved|investigational
HgeneKCNQ1P51787DB01244BepridilPotassium voltage-gated channel subfamily KQT member 1 {ECO:0000305}small moleculeapproved|withdrawn

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RelatedDiseases for KCNQ1_TSPAN32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKCNQ1C0035828Romano-Ward Syndrome36CTD_human;ORPHANET;UNIPROT
HgeneKCNQ1C0022387Jervell-Lange Nielsen Syndrome9CTD_human;ORPHANET;UNIPROT
HgeneKCNQ1C0023976Long QT Syndrome7CTD_human
HgeneKCNQ1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneKCNQ1C0001418Adenocarcinoma1CTD_human
HgeneKCNQ1C0018781Noise-induced hearing loss1CTD_human
HgeneKCNQ1C0021841Intestinal Neoplasms1CTD_human
HgeneKCNQ1C1837014Atrial Fibrillation, Familial, 31CTD_human;UNIPROT
HgeneKCNQ1C1865019SHORT QT SYNDROME 2 (disorder)1CTD_human;UNIPROT