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Fusion gene ID: 18297

FusionGeneSummary for KCNMA1_KCNMA1

Fusion gene summary

Fusion gene information	Fusion gene name: KCNMA1_KCNMA1
	Fusion gene ID: 18297
		Hgene	Tgene
	Gene symbol	KCNMA1	KCNMA1
	Gene ID	3778	3778
	Gene name	potassium calcium-activated channel subfamily M alpha 1	potassium calcium-activated channel subfamily M alpha 1
	Synonyms	BKTM\|CADEDS\|KCa1.1\|MaxiK\|PNKD3\|SAKCA\|SLO\|SLO-ALPHA\|SLO1\|bA205K10.1\|hSlo\|mSLO1	BKTM\|CADEDS\|KCa1.1\|MaxiK\|PNKD3\|SAKCA\|SLO\|SLO-ALPHA\|SLO1\|bA205K10.1\|hSlo\|mSLO1
	Cytomap	10q22.3	10q22.3
	Type of gene	protein-coding	protein-coding
	Description	calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo	calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo
	Modification date	20180523	20180523
	UniProtAcc	Q12791	Q12791
	Ensembl transtripts involved in fusion gene	ENST00000404771, ENST00000372440, ENST00000372443, ENST00000286628, ENST00000286627, ENST00000354353, ENST00000404857, ENST00000406533, ENST00000484507, ENST00000481070, ENST00000480683,	ENST00000404771, ENST00000372440, ENST00000372443, ENST00000286628, ENST00000286627, ENST00000354353, ENST00000404857, ENST00000406533, ENST00000484507, ENST00000481070, ENST00000480683,
Fusion gene scores	* DoF score	15 X 12 X 8=1440	11 X 10 X 6=660
	# samples	17	13
	** MAII score	log2(17/1440*10)=-3.08246216019197 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KCNMA1 [Title/Abstract] AND KCNMA1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KCNMA1	GO:0001666	response to hypoxia	15528406
Hgene	KCNMA1	GO:0006813	potassium ion transport	7573516\|7877450\|11245614\|12388065\|17706472\|18458941
Hgene	KCNMA1	GO:0006970	response to osmotic stress	10840032\|12388065
Hgene	KCNMA1	GO:0030007	cellular potassium ion homeostasis	11245614
Hgene	KCNMA1	GO:0034465	response to carbon monoxide	15528406
Hgene	KCNMA1	GO:0042391	regulation of membrane potential	7877450\|7993625
Hgene	KCNMA1	GO:0045794	negative regulation of cell volume	12388065
Hgene	KCNMA1	GO:0051592	response to calcium ion	12388065\|18458941
Hgene	KCNMA1	GO:0060073	micturition	11641143
Hgene	KCNMA1	GO:0060083	smooth muscle contraction involved in micturition	11641143
Tgene	KCNMA1	GO:0001666	response to hypoxia	15528406
Tgene	KCNMA1	GO:0006813	potassium ion transport	7573516\|7877450\|11245614\|12388065\|17706472\|18458941
Tgene	KCNMA1	GO:0006970	response to osmotic stress	10840032\|12388065
Tgene	KCNMA1	GO:0030007	cellular potassium ion homeostasis	11245614
Tgene	KCNMA1	GO:0034465	response to carbon monoxide	15528406
Tgene	KCNMA1	GO:0042391	regulation of membrane potential	7877450\|7993625
Tgene	KCNMA1	GO:0045794	negative regulation of cell volume	12388065
Tgene	KCNMA1	GO:0051592	response to calcium ion	12388065\|18458941
Tgene	KCNMA1	GO:0060073	micturition	11641143
Tgene	KCNMA1	GO:0060083	smooth muscle contraction involved in micturition	11641143

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA225487	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
ChiTaRS3.1			BE145278	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000404771	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372440	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000372443	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286628	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000286627	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000354353	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404857	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000406533	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000484507	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000481070	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000404771	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000372440	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000372443	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000286628	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000286627	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000354353	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000404857	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000406533	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000484507	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000481070	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000480683	ENST00000480683	KCNMA1	chr10	79146575	-	KCNMA1	chr10	79146505	+
intron-intron	ENST00000404771	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404771	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372440	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000372443	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286628	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000286627	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000354353	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000404857	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000406533	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000484507	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000481070	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000404771	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000372440	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000372443	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000286628	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000286627	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000354353	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000404857	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000406533	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000484507	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000481070	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-
intron-intron	ENST00000480683	ENST00000480683	KCNMA1	chr10	79197103	+	KCNMA1	chr10	79209195	-

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FusionProtFeatures for KCNMA1_KCNMA1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCNMA1 Q12791	KCNMA1 Q12791

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for KCNMA1_KCNMA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCNMA1_KCNMA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for KCNMA1_KCNMA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	KCNMA1	Q12791	DB00356	Chlorzoxazone	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Hgene	KCNMA1	Q12791	DB00436	Bendroflumethiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Hgene	KCNMA1	Q12791	DB01003	Cromoglicic acid	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Hgene	KCNMA1	Q12791	DB01119	Diazoxide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Hgene	KCNMA1	Q12791	DB09089	Trimebutine	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Hgene	KCNMA1	Q12791	DB00774	Hydroflumethiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational
Hgene	KCNMA1	Q12791	DB04209	Dequalinium	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational
Hgene	KCNMA1	Q12791	DB00721	Procaine	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational\|vet_approved
Hgene	KCNMA1	Q12791	DB01110	Miconazole	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational\|vet_approved
Hgene	KCNMA1	Q12791	DB00999	Hydrochlorothiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|vet_approved
Hgene	KCNMA1	Q12791	DB01159	Halothane	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|vet_approved
Tgene	KCNMA1	Q12791	DB00356	Chlorzoxazone	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Tgene	KCNMA1	Q12791	DB00436	Bendroflumethiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Tgene	KCNMA1	Q12791	DB01003	Cromoglicic acid	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Tgene	KCNMA1	Q12791	DB01119	Diazoxide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Tgene	KCNMA1	Q12791	DB09089	Trimebutine	Calcium-activated potassium channel subunit alpha-1	small molecule	approved
Tgene	KCNMA1	Q12791	DB00774	Hydroflumethiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational
Tgene	KCNMA1	Q12791	DB04209	Dequalinium	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational
Tgene	KCNMA1	Q12791	DB00721	Procaine	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational\|vet_approved
Tgene	KCNMA1	Q12791	DB01110	Miconazole	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|investigational\|vet_approved
Tgene	KCNMA1	Q12791	DB00999	Hydrochlorothiazide	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|vet_approved
Tgene	KCNMA1	Q12791	DB01159	Halothane	Calcium-activated potassium channel subunit alpha-1	small molecule	approved\|vet_approved

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RelatedDiseases for KCNMA1_KCNMA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KCNMA1	C0004352	Autistic Disorder	1	CTD_human
Hgene	KCNMA1	C0005944	Metabolic Bone Disorder	1	CTD_human
Hgene	KCNMA1	C0007134	Renal Cell Carcinoma	1	CTD_human
Hgene	KCNMA1	C0019284	Diaphragmatic Hernia	1	CTD_human
Hgene	KCNMA1	C0028756	Obesity, Morbid	1	CTD_human
Hgene	KCNMA1	C0038220	Status Epilepticus	1	CTD_human
Hgene	KCNMA1	C1836173	Generalized Epilepsy and Paroxysmal Dyskinesia	1	CTD_human;ORPHANET;UNIPROT
Tgene	KCNMA1	C0004352	Autistic Disorder	1	CTD_human
Tgene	KCNMA1	C0005944	Metabolic Bone Disorder	1	CTD_human
Tgene	KCNMA1	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	KCNMA1	C0019284	Diaphragmatic Hernia	1	CTD_human
Tgene	KCNMA1	C0028756	Obesity, Morbid	1	CTD_human
Tgene	KCNMA1	C0038220	Status Epilepticus	1	CTD_human
Tgene	KCNMA1	C1836173	Generalized Epilepsy and Paroxysmal Dyskinesia	1	CTD_human;ORPHANET;UNIPROT

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Fusion gene ID: 18297

FusionGeneSummary for KCNMA1_KCNMA1

FusionProtFeatures for KCNMA1_KCNMA1

FusionGeneSequence for KCNMA1_KCNMA1

FusionGenePPI for KCNMA1_KCNMA1

RelatedDrugs for KCNMA1_KCNMA1

RelatedDiseases for KCNMA1_KCNMA1