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Fusion gene ID: 18276 |
FusionGeneSummary for KCNJ3_KCNJ3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNJ3_KCNJ3 | Fusion gene ID: 18276 | Hgene | Tgene | Gene symbol | KCNJ3 | KCNJ3 | Gene ID | 3760 | 3760 |
| Gene name | potassium voltage-gated channel subfamily J member 3 | potassium voltage-gated channel subfamily J member 3 | |
| Synonyms | GIRK1|KGA|KIR3.1 | GIRK1|KGA|KIR3.1 | |
| Cytomap | 2q24.1 | 2q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G protein-activated inward rectifier potassium channel 1GIRK-1inward rectifier K(+) channel Kir3.1inward rectifier K+ channel KIR3.1potassium channel, inwardly rectifying subfamily J member 3potassium inwardly-rectifying channel subfamily J member 3 | G protein-activated inward rectifier potassium channel 1GIRK-1inward rectifier K(+) channel Kir3.1inward rectifier K+ channel KIR3.1potassium channel, inwardly rectifying subfamily J member 3potassium inwardly-rectifying channel subfamily J member 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P48549 | P48549 | |
| Ensembl transtripts involved in fusion gene | ENST00000295101, ENST00000544049, ENST00000493505, | ENST00000295101, ENST00000544049, ENST00000493505, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KCNJ3 [Title/Abstract] AND KCNJ3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNJ3 | GO:1990573 | potassium ion import across plasma membrane | 20560207 |
| Tgene | KCNJ3 | GO:1990573 | potassium ion import across plasma membrane | 20560207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA682965 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000295101 | ENST00000295101 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000295101 | ENST00000544049 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000295101 | ENST00000493505 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000544049 | ENST00000295101 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000544049 | ENST00000544049 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000544049 | ENST00000493505 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000493505 | ENST00000295101 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000493505 | ENST00000544049 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
| intron-intron | ENST00000493505 | ENST00000493505 | KCNJ3 | chr2 | 155646241 | + | KCNJ3 | chr2 | 155652935 | - |
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FusionProtFeatures for KCNJ3_KCNJ3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNJ3 | KCNJ3 |
| This potassium channel is controlled by G proteins.Inward rectifier potassium channels are characterized by a greatertendency to allow potassium to flow into the cell rather than outof it. Their voltage dependence is regulated by the concentrationof extracellular potassium; as external potassium is raised, thevoltage range of the channel opening shifts to more positivevoltages. The inward rectification is mainly due to the blockageof outward current by internal magnesium. This receptor plays acrucial role in regulating the heartbeat. | This potassium channel is controlled by G proteins.Inward rectifier potassium channels are characterized by a greatertendency to allow potassium to flow into the cell rather than outof it. Their voltage dependence is regulated by the concentrationof extracellular potassium; as external potassium is raised, thevoltage range of the channel opening shifts to more positivevoltages. The inward rectification is mainly due to the blockageof outward current by internal magnesium. This receptor plays acrucial role in regulating the heartbeat. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KCNJ3_KCNJ3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KCNJ3_KCNJ3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCNJ3_KCNJ3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KCNJ3 | P48549 | DB00898 | Ethanol | G protein-activated inward rectifier potassium channel 1 | small molecule | approved |
| Hgene | KCNJ3 | P48549 | DB01159 | Halothane | G protein-activated inward rectifier potassium channel 1 | small molecule | approved|vet_approved |
| Tgene | KCNJ3 | P48549 | DB00898 | Ethanol | G protein-activated inward rectifier potassium channel 1 | small molecule | approved |
| Tgene | KCNJ3 | P48549 | DB01159 | Halothane | G protein-activated inward rectifier potassium channel 1 | small molecule | approved|vet_approved |
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RelatedDiseases for KCNJ3_KCNJ3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KCNJ3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | KCNJ3 | C0036341 | Schizophrenia | 1 | PSYGENET |
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