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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18262

FusionGeneSummary for KCNIP1_TROVE2

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNIP1_TROVE2
Fusion gene ID: 18262
HgeneTgene
Gene symbol

KCNIP1

TROVE2

Gene ID

30820

6738

Gene namepotassium voltage-gated channel interacting protein 1TROVE domain family member 2
SynonymsKCHIP1|VABPRO60|RORNP|SSA2
Cytomap

5q35.1

1q31.2

Type of geneprotein-codingprotein-coding
DescriptionKv channel-interacting protein 1A-type potassium channel modulatory protein 1Kv channel interacting protein 1potassium channel interacting protein 1vesicle APC-binding protein60 kDa SS-A/Ro ribonucleoprotein60 kDa ribonucleoprotein RoSjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)gastric cancer multi-drug resistance proteinsjoegren syndrome type A antigen
Modification date2018052220180519
UniProtAcc

Q9NZI2

P10155

Ensembl transtripts involved in fusion geneENST00000518527, ENST00000377360, 
ENST00000328939, ENST00000390656, 
ENST00000520740, ENST00000434108, 
ENST00000411494, 
ENST00000400968, 
ENST00000432079, ENST00000460715, 
ENST00000416058, ENST00000367446, 
ENST00000367445, ENST00000367444, 
ENST00000367443, ENST00000367441, 
Fusion gene scores* DoF score4 X 5 X 1=203 X 3 X 2=18
# samples 64
** MAII scorelog2(6/20*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCNIP1 [Title/Abstract] AND TROVE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNIP1

GO:1901379

regulation of potassium ion transmembrane transport

10676964|17187064


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA074210KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000518527ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000518527ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000518527ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000377360ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000377360ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000328939ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000328939ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000390656ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000390656ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000520740ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000520740ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000434108ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000434108ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000400968KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-3UTRENST00000411494ENST00000432079KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000460715KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000416058KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000367446KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000367445KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000367444KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000367443KCNIP1chr5

169793046

-TROVE2chr1

193057020

+
intron-intronENST00000411494ENST00000367441KCNIP1chr5

169793046

-TROVE2chr1

193057020

+

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FusionProtFeatures for KCNIP1_TROVE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNIP1

Q9NZI2

TROVE2

P10155

Regulatory subunit of Kv4/D (Shal)-type voltage-gatedrapidly inactivating A-type potassium channels. Regulates channeldensity, inactivation kinetics and rate of recovery frominactivation in a calcium-dependent and isoform-specific manner.In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents.Increases the presence of KCND2 at the cell surface.{ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117,ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCNIP1_TROVE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCNIP1_TROVE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCNIP1_TROVE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCNIP1_TROVE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource