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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18259

FusionGeneSummary for KCNIP1_KCNIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNIP1_KCNIP1
Fusion gene ID: 18259
HgeneTgene
Gene symbol

KCNIP1

KCNIP1

Gene ID

30820

30820

Gene namepotassium voltage-gated channel interacting protein 1potassium voltage-gated channel interacting protein 1
SynonymsKCHIP1|VABPKCHIP1|VABP
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionKv channel-interacting protein 1A-type potassium channel modulatory protein 1Kv channel interacting protein 1potassium channel interacting protein 1vesicle APC-binding proteinKv channel-interacting protein 1A-type potassium channel modulatory protein 1Kv channel interacting protein 1potassium channel interacting protein 1vesicle APC-binding protein
Modification date2018052220180522
UniProtAcc

Q9NZI2

Q9NZI2

Ensembl transtripts involved in fusion geneENST00000518527, ENST00000377360, 
ENST00000328939, ENST00000390656, 
ENST00000520740, ENST00000434108, 
ENST00000411494, 		ENST00000518527, 
ENST00000377360, ENST00000328939, 
ENST00000390656, ENST00000520740, 
ENST00000434108, ENST00000411494, 
Fusion gene scores* DoF score4 X 5 X 1=207 X 7 X 5=245
# samples 610
** MAII scorelog2(6/20*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNIP1 [Title/Abstract] AND KCNIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNIP1

GO:1901379

regulation of potassium ion transmembrane transport

10676964|17187064

TgeneKCNIP1

GO:1901379

regulation of potassium ion transmembrane transport

10676964|17187064


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV314228KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
ChiTaRS3.1BF767818KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000518527ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000377360ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000328939ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000390656ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000520740ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000434108ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000518527KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000377360KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000328939KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000390656KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000520740KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000434108KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000411494ENST00000411494KCNIP1chr5

170033733

+KCNIP1chr5

170033637

-
intron-intronENST00000518527ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000518527ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000377360ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000328939ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000390656ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000520740ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000434108ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000518527KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000377360KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000328939KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000390656KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000520740KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000434108KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+
intron-intronENST00000411494ENST00000411494KCNIP1chr5

169805642

-KCNIP1chr5

169805893

+

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FusionProtFeatures for KCNIP1_KCNIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNIP1

Q9NZI2

KCNIP1

Q9NZI2

Regulatory subunit of Kv4/D (Shal)-type voltage-gatedrapidly inactivating A-type potassium channels. Regulates channeldensity, inactivation kinetics and rate of recovery frominactivation in a calcium-dependent and isoform-specific manner.In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents.Increases the presence of KCND2 at the cell surface.{ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117,ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}. Regulatory subunit of Kv4/D (Shal)-type voltage-gatedrapidly inactivating A-type potassium channels. Regulates channeldensity, inactivation kinetics and rate of recovery frominactivation in a calcium-dependent and isoform-specific manner.In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents.Increases the presence of KCND2 at the cell surface.{ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117,ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCNIP1_KCNIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCNIP1_KCNIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCNIP1_KCNIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCNIP1_KCNIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource