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Fusion gene ID: 18258 |
FusionGeneSummary for KCNH7_ZNF16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNH7_ZNF16 | Fusion gene ID: 18258 | Hgene | Tgene | Gene symbol | KCNH7 | ZNF16 | Gene ID | 90134 | 7564 |
| Gene name | potassium voltage-gated channel subfamily H member 7 | zinc finger protein 16 | |
| Synonyms | ERG3|HERG3|Kv11.3 | HZF1|KOX9 | |
| Cytomap | 2q24.2 | 8q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | potassium voltage-gated channel subfamily H member 7ERG-3eag-related protein 3ether-a-go-go-related gene potassium channel 3ether-a-go-go-related protein 3potassium channel subunit HERG-3potassium channel, voltage gated eag related subfamily H, memb | zinc finger protein 16zinc finger protein KOX9zinc finger protein Kruppel type 9 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9NS40 | P17020 | |
| Ensembl transtripts involved in fusion gene | ENST00000332142, ENST00000328032, ENST00000477019, | ENST00000276816, ENST00000394909, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 2=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KCNH7 [Title/Abstract] AND ZNF16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZNF16 | GO:0008284 | positive regulation of cell proliferation | 21874239 |
| Tgene | ZNF16 | GO:0033674 | positive regulation of kinase activity | 21874239 |
| Tgene | ZNF16 | GO:0043066 | negative regulation of apoptotic process | 21874239 |
| Tgene | ZNF16 | GO:0072707 | cellular response to sodium dodecyl sulfate | 21874239 |
| Tgene | ZNF16 | GO:1901989 | positive regulation of cell cycle phase transition | 21874239 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW811810 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000332142 | ENST00000276816 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| intron-intron | ENST00000332142 | ENST00000394909 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| intron-intron | ENST00000328032 | ENST00000276816 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| intron-intron | ENST00000328032 | ENST00000394909 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| intron-intron | ENST00000477019 | ENST00000276816 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
| intron-intron | ENST00000477019 | ENST00000394909 | KCNH7 | chr2 | 163383517 | - | ZNF16 | chr8 | 146160678 | - |
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FusionProtFeatures for KCNH7_ZNF16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNH7 | ZNF16 |
| Pore-forming (alpha) subunit of voltage-gated potassiumchannel. Channel properties may be modulated by cAMP and subunitassembly. | Acts as a transcriptional activator. Promotes cellproliferation by facilitating the cell cycle phase transition fromthe S to G2/M phase. Involved in both the hemin- and phorbolmyristate acetate (PMA)-induced erythroid and megakaryocyticdifferentiation, respectively. Plays also a role as an inhibitorof cell apoptosis. {ECO:0000269|PubMed:16628192,ECO:0000269|PubMed:19763908, ECO:0000269|PubMed:21874239}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KCNH7_ZNF16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KCNH7_ZNF16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCNH7_ZNF16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KCNH7 | Q9NS40 | DB00308 | Ibutilide | Potassium voltage-gated channel subfamily H member 7 | small molecule | approved |
| Hgene | KCNH7 | Q9NS40 | DB00457 | Prazosin | Potassium voltage-gated channel subfamily H member 7 | small molecule | approved |
| Hgene | KCNH7 | Q9NS40 | DB00590 | Doxazosin | Potassium voltage-gated channel subfamily H member 7 | small molecule | approved |
| Hgene | KCNH7 | Q9NS40 | DB01162 | Terazosin | Potassium voltage-gated channel subfamily H member 7 | small molecule | approved |
| Hgene | KCNH7 | Q9NS40 | DB01110 | Miconazole | Potassium voltage-gated channel subfamily H member 7 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for KCNH7_ZNF16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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