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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18201

FusionGeneSummary for KATNA1_RALYL

check button Fusion gene summary
Fusion gene informationFusion gene name: KATNA1_RALYL
Fusion gene ID: 18201
HgeneTgene
Gene symbol

KATNA1

RALYL

Gene ID

11104

138046

Gene namekatanin catalytic subunit A1RALY RNA binding protein like
Synonyms-HNRPCL3
Cytomap

6q25.1

8q21.2

Type of geneprotein-codingprotein-coding
Descriptionkatanin p60 ATPase-containing subunit A1katanin p60 (ATPase containing) subunit A 1katanin p60 subunit A1p60 kataninRNA-binding Raly-like proteinheterogeneous nuclear ribonucleoprotein C-like 3hnRNP core protein C-like 3
Modification date2018052320180523
UniProtAcc

O75449

Q86SE5

Ensembl transtripts involved in fusion geneENST00000335647, ENST00000335643, 
ENST00000367411, ENST00000494504, 
ENST00000522455, ENST00000521695, 
ENST00000521268, ENST00000518566, 
ENST00000517638, ENST00000523850, 
ENST00000521376, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 5 X 9=405
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KATNA1 [Title/Abstract] AND RALYL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01AKATNA1chr6

149969605

-RALYLchr8

85441534

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000335647ENST00000522455KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000335647ENST00000521695KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000335647ENST00000521268KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000335647ENST00000518566KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000335647ENST00000517638KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-intronENST00000335647ENST00000523850KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-intronENST00000335647ENST00000521376KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000335643ENST00000522455KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000335643ENST00000521695KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000335643ENST00000521268KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000335643ENST00000518566KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000335643ENST00000517638KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-intronENST00000335643ENST00000523850KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-intronENST00000335643ENST00000521376KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000367411ENST00000522455KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000367411ENST00000521695KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000367411ENST00000521268KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000367411ENST00000518566KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-5UTRENST00000367411ENST00000517638KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-intronENST00000367411ENST00000523850KATNA1chr6

149969605

-RALYLchr8

85441534

+
5UTR-intronENST00000367411ENST00000521376KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000494504ENST00000522455KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000494504ENST00000521695KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000494504ENST00000521268KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000494504ENST00000518566KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-5UTRENST00000494504ENST00000517638KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-intronENST00000494504ENST00000523850KATNA1chr6

149969605

-RALYLchr8

85441534

+
intron-intronENST00000494504ENST00000521376KATNA1chr6

149969605

-RALYLchr8

85441534

+

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FusionProtFeatures for KATNA1_RALYL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KATNA1

O75449

RALYL

Q86SE5

Catalytic subunit of a complex which severs microtubulesin an ATP-dependent manner. Microtubule severing may promote rapidreorganization of cellular microtubule arrays and the release ofmicrotubules from the centrosome following nucleation. Microtubulerelease from the mitotic spindle poles may allow depolymerizationof the microtubule end proximal to the spindle pole, leading topoleward microtubule flux and poleward motion of chromosome.Microtubule release within the cell body of neurons may berequired for their transport into neuronal processes bymicrotubule-dependent motor proteins. This transport is requiredfor axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023,ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226,ECO:0000269|PubMed:19287380}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KATNA1_RALYL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KATNA1_RALYL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KATNA1KLHL42, CUL3, UBR5, DYRK2, VPRBP, DDB1, SH3KBP1, KATNB1, NDEL1, DYNC1H1, PAFAH1B1, CLU, USP47, STUB1, HSP90AA1, HSPA1A, KATNBL1, APP, CLK1, SSX2IP, ODF2, CAPN1, MAPT, SRSF2, SRSF3, SOAT1, SPTBN1, SRPR, USP1, AKR7A2, LATS1, SORBS3, GOLT1B, RTEL1, NCKAP5L, SRPRB, ENOPH1, ARHGAP39, SLC30A7, CCDC88C, INPP5K, PFDN4, CCT7, ARIH1, LACRT, ASB3RALYLTHAP1, LMO3, FXR2, MCRS1, RALYL, C20orf27, AEBP2, HNRNPC, ZNF408, CCDC85B, EWSR1, RBM41, CEP170P1, VHL, LRRK2, PSMF1, TSNAX, BYSL, AEN, CCDC9, SKA2, ELAVL2, CRNKL1, SF3A1, RBM22, TRAF7, CDC40, PNN, ZC3H14, XAB2, DGCR14, CCDC12, RALY, YTHDC1, PRKRA, ISY1, AQR, CWF19L1, FBXW7, PPIE, RBM3, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KATNA1_RALYL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KATNA1_RALYL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRALYLC1458155Mammary Neoplasms1CTD_human