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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18184

FusionGeneSummary for KAT6B_DDX4

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6B_DDX4
Fusion gene ID: 18184
HgeneTgene
Gene symbol

KAT6B

DDX4

Gene ID

23522

54514

Gene namelysine acetyltransferase 6BDEAD-box helicase 4
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfVASA
Cytomap

10q22.2

5q11.2

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone aprobable ATP-dependent RNA helicase DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4DEAD box protein 4DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4vasa homolog
Modification date2018052320180522
UniProtAcc

Q8WYB5

Q9NQI0

Ensembl transtripts involved in fusion geneENST00000372725, ENST00000372724, 
ENST00000287239, ENST00000372714, 
ENST00000372711, ENST00000490365, 
ENST00000514278, ENST00000353507, 
ENST00000505374, ENST00000508580, 
ENST00000354991, ENST00000511853, 
Fusion gene scores* DoF score11 X 9 X 4=3962 X 1 X 2=4
# samples 112
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: KAT6B [Title/Abstract] AND DDX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A228-01AKAT6Bchr10

76748870

+DDX4chr5

55034778

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000372725ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372725ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372725ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372725ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372725ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-intronENST00000372725ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372724ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372724ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372724ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372724ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372724ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-intronENST00000372724ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000287239ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000287239ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000287239ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000287239ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000287239ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-intronENST00000287239ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372714ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372714ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372714ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372714ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372714ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-intronENST00000372714ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372711ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372711ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-5UTRENST00000372711ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372711ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-3UTRENST00000372711ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
5CDS-intronENST00000372711ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-5UTRENST00000490365ENST00000514278KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-5UTRENST00000490365ENST00000353507KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-5UTRENST00000490365ENST00000505374KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-3UTRENST00000490365ENST00000508580KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-3UTRENST00000490365ENST00000354991KAT6Bchr10

76748870

+DDX4chr5

55034778

+
3UTR-intronENST00000490365ENST00000511853KAT6Bchr10

76748870

+DDX4chr5

55034778

+

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FusionProtFeatures for KAT6B_DDX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6B

Q8WYB5

DDX4

Q9NQI0

Histone acetyltransferase which may be involved in bothpositive and negative regulation of transcription. Required forRUNX2-dependent transcriptional activation. May be involved incerebral cortex development. Component of the MOZ/MORF complexwhich has a histone H3 acetyltransferase activity.{ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KAT6B_DDX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KAT6B_DDX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KAT6BRUNX2, RUNX1, ING5, ATN1, HIST3H3, UBE2I, SGOL1, MEAF6DDX4SPSB1, SPSB2, SPSB4, CUL3, DCUN1D1, CAND1, SMAD3, SRC, USP7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT6B_DDX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT6B_DDX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6BC0853193Bipolar I disorder1PSYGENET
HgeneKAT6BC3495559Juvenile arthritis1CTD_human