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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18173

FusionGeneSummary for KAT6A_KAT6A

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6A_KAT6A
Fusion gene ID: 18173
HgeneTgene
Gene symbol

KAT6A

KAT6A

Gene ID

7994

7994

Gene namelysine acetyltransferase 6Alysine acetyltransferase 6A
SynonymsMOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220
Cytomap

8p11.21

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription
Modification date2018052320180523
UniProtAcc

Q92794

Q92794

Ensembl transtripts involved in fusion geneENST00000406337, ENST00000265713, 
ENST00000396930, ENST00000485568, 
ENST00000406337, ENST00000265713, 
ENST00000396930, ENST00000485568, 
Fusion gene scores* DoF score16 X 12 X 6=11526 X 11 X 4=264
# samples 2611
** MAII scorelog2(26/1152*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/264*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT6A [Title/Abstract] AND KAT6A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358

TgeneKAT6A

GO:0006473

protein acetylation

23431171

TgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

TgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

TgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

TgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

TgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA314440KAT6Achr8

41788641

+KAT6Achr8

41788955

-
ChiTaRS3.1AA868356KAT6Achr8

41895620

+KAT6Achr8

41850830

+
ChiTaRS3.1BP318953KAT6Achr8

41792245

-KAT6Achr8

41798753

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000406337ENST00000406337KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000406337ENST00000265713KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000406337ENST00000396930KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-intronENST00000406337ENST00000485568KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000265713ENST00000406337KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000265713ENST00000265713KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000265713ENST00000396930KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-intronENST00000265713ENST00000485568KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000396930ENST00000406337KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000396930ENST00000265713KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000396930ENST00000396930KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-intronENST00000396930ENST00000485568KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000485568ENST00000406337KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000485568ENST00000265713KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-3UTRENST00000485568ENST00000396930KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-intronENST00000485568ENST00000485568KAT6Achr8

41788641

+KAT6Achr8

41788955

-
intron-intronENST00000406337ENST00000406337KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000406337ENST00000265713KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000406337ENST00000396930KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000406337ENST00000485568KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000265713ENST00000406337KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000265713ENST00000265713KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000265713ENST00000396930KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000265713ENST00000485568KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000396930ENST00000406337KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000396930ENST00000265713KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000396930ENST00000396930KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000396930ENST00000485568KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000485568ENST00000406337KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000485568ENST00000265713KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000485568ENST00000396930KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-intronENST00000485568ENST00000485568KAT6Achr8

41895620

+KAT6Achr8

41850830

+
intron-3CDSENST00000406337ENST00000406337KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000406337ENST00000265713KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000406337ENST00000396930KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-intronENST00000406337ENST00000485568KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000265713ENST00000406337KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000265713ENST00000265713KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000265713ENST00000396930KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-intronENST00000265713ENST00000485568KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000396930ENST00000406337KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000396930ENST00000265713KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000396930ENST00000396930KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-intronENST00000396930ENST00000485568KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000485568ENST00000406337KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000485568ENST00000265713KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-3CDSENST00000485568ENST00000396930KAT6Achr8

41792245

-KAT6Achr8

41798753

-
intron-intronENST00000485568ENST00000485568KAT6Achr8

41792245

-KAT6Achr8

41798753

-

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FusionProtFeatures for KAT6A_KAT6A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

KAT6A

Q92794

Histone acetyltransferase that acetylates lysineresidues in histone H3 and histone H4 (in vitro). Component of theMOZ/MORF complex which has a histone H3 acetyltransferaseactivity. May act as a transcriptional coactivator for RUNX1 andRUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controlsits transcriptional activity via association with PML.{ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. Histone acetyltransferase that acetylates lysineresidues in histone H3 and histone H4 (in vitro). Component of theMOZ/MORF complex which has a histone H3 acetyltransferaseactivity. May act as a transcriptional coactivator for RUNX1 andRUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controlsits transcriptional activity via association with PML.{ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KAT6A_KAT6A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KAT6A_KAT6A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT6A_KAT6A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT6A_KAT6A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human
TgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneKAT6AC0025149Medulloblastoma1CTD_human