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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1817

FusionGeneSummary for ANKRD26_ANKRD26

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD26_ANKRD26
Fusion gene ID: 1817
HgeneTgene
Gene symbol

ANKRD26

ANKRD26

Gene ID

22852

22852

Gene nameankyrin repeat domain 26ankyrin repeat domain 26
SynonymsTHC2|bA145E8.1THC2|bA145E8.1
Cytomap

10p12.1

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 26GNS/ANKRD26/NCKAP1L fusionankyrin repeat domain-containing protein 26GNS/ANKRD26/NCKAP1L fusion
Modification date2018051920180519
UniProtAcc

Q9UPS8

Q9UPS8

Ensembl transtripts involved in fusion geneENST00000376070, ENST00000376087, 
ENST00000436985, ENST00000466890, 
ENST00000376070, ENST00000376087, 
ENST00000436985, ENST00000466890, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD26 [Title/Abstract] AND ANKRD26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM450509ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000376070ENST00000376070ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000376070ENST00000376087ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000376070ENST00000436985ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
5CDS-intronENST00000376070ENST00000466890ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000376087ENST00000376070ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000376087ENST00000376087ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000376087ENST00000436985ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
5CDS-intronENST00000376087ENST00000466890ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000436985ENST00000376070ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000436985ENST00000376087ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
In-frameENST00000436985ENST00000436985ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
5CDS-intronENST00000436985ENST00000466890ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
intron-3CDSENST00000466890ENST00000376070ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
intron-3CDSENST00000466890ENST00000376087ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
intron-3CDSENST00000466890ENST00000436985ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-
intron-intronENST00000466890ENST00000466890ANKRD26chr10

27311485

-ANKRD26chr10

27337911

-

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FusionProtFeatures for ANKRD26_ANKRD26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD26

Q9UPS8

ANKRD26

Q9UPS8

Acts as a regulator of adipogenesis. Involved in theregulation of the feeding behavior.{ECO:0000250|UniProtKB:Q811D2}. Acts as a regulator of adipogenesis. Involved in theregulation of the feeding behavior.{ECO:0000250|UniProtKB:Q811D2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419529_5669621268Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419742_8729621268Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934529_56614051711Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934742_87214051711Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-141925_289621268Compositional biasNote=Poly-Gly
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419574_5799621268Compositional biasNote=Poly-Asp
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-293425_2814051711Compositional biasNote=Poly-Gly
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934574_57914051711Compositional biasNote=Poly-Asp
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419112_1419621268RepeatNote=ANK 3
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419145_1749621268RepeatNote=ANK 4
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419178_2079621268RepeatNote=ANK 5
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-141945_759621268RepeatNote=ANK 1
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-141979_1089621268RepeatNote=ANK 2
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934112_14114051711RepeatNote=ANK 3
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934145_17414051711RepeatNote=ANK 4
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934178_20714051711RepeatNote=ANK 5
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-293445_7514051711RepeatNote=ANK 1
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-293479_10814051711RepeatNote=ANK 2
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-0191516_15861021268Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-0191648_16731021268Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019529_5661021268Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019742_8721021268Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019904_14711021268Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-15341516_15865451711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-15341648_16735451711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534742_8725451711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534904_14715451711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019574_5791021268Compositional biasNote=Poly-Asp
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534574_5795451711Compositional biasNote=Poly-Asp
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019112_1411021268RepeatNote=ANK 3
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019145_1741021268RepeatNote=ANK 4
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-019178_2071021268RepeatNote=ANK 5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-14191516_15869621268Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-14191648_16739621268Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-1419904_14719621268Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-29341516_158614051711Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-29341648_167314051711Coiled coilOntology_term=ECO:0000255
HgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-2934904_147114051711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534529_5665451711Coiled coilOntology_term=ECO:0000255
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-01925_281021268Compositional biasNote=Poly-Gly
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-153425_285451711Compositional biasNote=Poly-Gly
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-01945_751021268RepeatNote=ANK 1
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376070-01979_1081021268RepeatNote=ANK 2
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534112_1415451711RepeatNote=ANK 3
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534145_1745451711RepeatNote=ANK 4
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-1534178_2075451711RepeatNote=ANK 5
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-153445_755451711RepeatNote=ANK 1
TgeneANKRD26chr10:27311485chr10:27337911ENST00000376087-153479_1085451711RepeatNote=ANK 2


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FusionGeneSequence for ANKRD26_ANKRD26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD26_ANKRD26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD26BRCA1, CBX2, CBX4, AMOT, PRKAR1A, MED4, PCM1, CEP128, CEP89, CNTRL, CCDC40, NDEL1, RALBP1ANKRD26BRCA1, CBX2, CBX4, AMOT, PRKAR1A, MED4, PCM1, CEP128, CEP89, CNTRL, CCDC40, NDEL1, RALBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD26_ANKRD26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD26_ANKRD26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource