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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18164

FusionGeneSummary for KAT5_KAT5

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT5_KAT5
Fusion gene ID: 18164
HgeneTgene
Gene symbol

KAT5

KAT5

Gene ID

10524

10524

Gene namelysine acetyltransferase 5lysine acetyltransferase 5
SynonymsESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2ESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT560 kDa Tat-interactive proteinHIV-1 Tat interactive protein, 60kDaK(lysine) acetyltransferase 5K-acetyltransferase 5Tat interacting protein, 60kDacPLA(2)-interacting proteincPLA2 interacting proteinhistone acetyltranshistone acetyltransferase KAT560 kDa Tat-interactive proteinHIV-1 Tat interactive protein, 60kDaK(lysine) acetyltransferase 5K-acetyltransferase 5Tat interacting protein, 60kDacPLA(2)-interacting proteincPLA2 interacting proteinhistone acetyltrans
Modification date2018052320180523
UniProtAcc

Q92993

Q92993

Ensembl transtripts involved in fusion geneENST00000377046, ENST00000352980, 
ENST00000341318, ENST00000530446, 
ENST00000534650, ENST00000525204, 
ENST00000377046, ENST00000352980, 
ENST00000341318, ENST00000530446, 
ENST00000534650, ENST00000525204, 
Fusion gene scores* DoF score1 X 2 X 1=21 X 2 X 1=2
# samples 33
** MAII scorelog2(3/2*10)=3.90689059560852log2(3/2*10)=3.90689059560852
Context

PubMed: KAT5 [Title/Abstract] AND KAT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT5

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14966270

HgeneKAT5

GO:0010212

response to ionizing radiation

18397884

HgeneKAT5

GO:0016573

histone acetylation

10966108

HgeneKAT5

GO:0032703

negative regulation of interleukin-2 production

17360565

HgeneKAT5

GO:0045892

negative regulation of transcription, DNA-templated

17360565

HgeneKAT5

GO:0045893

positive regulation of transcription, DNA-templated

14966270

HgeneKAT5

GO:0071392

cellular response to estradiol stimulus

23637611

HgeneKAT5

GO:1901985

positive regulation of protein acetylation

24012345

TgeneKAT5

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14966270

TgeneKAT5

GO:0010212

response to ionizing radiation

18397884

TgeneKAT5

GO:0016573

histone acetylation

10966108

TgeneKAT5

GO:0032703

negative regulation of interleukin-2 production

17360565

TgeneKAT5

GO:0045892

negative regulation of transcription, DNA-templated

17360565

TgeneKAT5

GO:0045893

positive regulation of transcription, DNA-templated

14966270

TgeneKAT5

GO:0071392

cellular response to estradiol stimulus

23637611

TgeneKAT5

GO:1901985

positive regulation of protein acetylation

24012345


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CR735169KAT5chr11

65482186

+KAT5chr11

65480241

+
ChiTaRS3.1AA344110KAT5chr11

65484234

+KAT5chr11

65481975

+
ChiTaRS3.1BE731511KAT5chr11

65482186

+KAT5chr11

65480241

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000377046ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000377046ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000377046ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000377046ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000377046ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000377046ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000352980ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000352980ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000352980ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000352980ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000352980ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000352980ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000341318ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000341318ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000341318ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000341318ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000341318ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000341318ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000530446ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000530446ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000530446ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000530446ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000530446ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000530446ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000534650ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000534650ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000534650ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shitENST00000534650ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000534650ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000534650ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-5UTRENST00000525204ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3UTRENST00000525204ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
In-frameENST00000377046ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000377046ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000377046ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000352980ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000352980ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000341318ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000341318ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000530446ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000530446ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000534650ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000534650ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-5UTRENST00000525204ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-intronENST00000525204ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+

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FusionProtFeatures for KAT5_KAT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT5

Q92993

KAT5

Q92993


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KAT5_KAT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KAT5_KAT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT5_KAT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT5_KAT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource