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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18153

FusionGeneSummary for KANSL3_ANKRD36

check button Fusion gene summary
Fusion gene informationFusion gene name: KANSL3_ANKRD36
Fusion gene ID: 18153
HgeneTgene
Gene symbol

KANSL3

ANKRD36

Gene ID

55683

375248

Gene nameKAT8 regulatory NSL complex subunit 3ankyrin repeat domain 36
SynonymsKIAA1310|NSL3|Rcd1UNQ2430
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
DescriptionKAT8 regulatory NSL complex subunit 3NSL complex protein NSL3non-specific lethal 3 homologserum inhibited-related proteintestis development protein PRTDankyrin repeat domain-containing protein 36Aankyrin repeat domain-containing protein 36ankyrin-related
Modification date2018052320180519
UniProtAcc

Q9P2N6

A6QL64

Ensembl transtripts involved in fusion geneENST00000487070, ENST00000431828, 
ENST00000599854, ENST00000441706, 
ENST00000440133, ENST00000435669, 
ENST00000461153, ENST00000420699, 
ENST00000357042, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 53
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: KANSL3 [Title/Abstract] AND ANKRD36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKANSL3

GO:0043981

histone H4-K5 acetylation

20018852

HgeneKANSL3

GO:0043982

histone H4-K8 acetylation

20018852

HgeneKANSL3

GO:0043984

histone H4-K16 acetylation

20018852


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-36-1575-01AKANSL3chr2

97297049

-ANKRD36chr2

97930066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000487070ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5UTR-3UTRENST00000487070ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5UTR-intronENST00000487070ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000431828ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-3UTRENST00000431828ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000431828ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000599854ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-3UTRENST00000599854ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000599854ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000441706ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-3UTRENST00000441706ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000441706ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5UTR-intronENST00000440133ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5UTR-3UTRENST00000440133ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5UTR-intronENST00000440133ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000435669ENST00000461153KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-3UTRENST00000435669ENST00000420699KANSL3chr2

97297049

-ANKRD36chr2

97930066

+
5CDS-intronENST00000435669ENST00000357042KANSL3chr2

97297049

-ANKRD36chr2

97930066

+

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FusionProtFeatures for KANSL3_ANKRD36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KANSL3

Q9P2N6

ANKRD36

A6QL64


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KANSL3_ANKRD36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KANSL3_ANKRD36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KANSL3CNOT2, STAT5B, SAMHD1, FOXK2, PHF20, ANKMY2, CAMK2D, TRIM25ANKRD36GAPDH, PER3, GAN, TSC22D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KANSL3_ANKRD36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KANSL3_ANKRD36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource