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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18119

FusionGeneSummary for KALRN_CREB5

check button Fusion gene summary
Fusion gene informationFusion gene name: KALRN_CREB5
Fusion gene ID: 18119
HgeneTgene
Gene symbol

KALRN

CREB5

Gene ID

8997

9586

Gene namekalirin RhoGEF kinasecAMP responsive element binding protein 5
SynonymsARHGEF24|CHD5|CHDS5|DUET|DUO|HAPIP|TRADCRE-BPA|CREB-5
Cytomap

3q21.1-q21.2

7p15.1

Type of geneprotein-codingprotein-coding
Descriptionkalirinhuntingtin-associated protein interacting protein (duo)serine/threonine-protein kinase with Dbl- and pleckstrin homology domaincyclic AMP-responsive element-binding protein 5cAMP response element-binding protein CRE-BPa
Modification date2018051920180519
UniProtAcc

O60229

Q02930

Ensembl transtripts involved in fusion geneENST00000477496, ENST00000460856, 
ENST00000240874, ENST00000360013, 
ENST00000393496, ENST00000291478, 
ENST00000428018, ENST00000459915, 
ENST00000462213, 
ENST00000396299, 
ENST00000357727, ENST00000396300, 
ENST00000409603, ENST00000396298, 
ENST00000482692, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 7 X 5=315
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KALRN [Title/Abstract] AND CREB5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREB5

GO:0045893

positive regulation of transcription, DNA-templated

8378084


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A1OH-01AKALRNchr3

124352800

+CREB5chr7

28527793

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000477496ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000477496ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-5UTRENST00000477496ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000477496ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000477496ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000477496ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000460856ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000460856ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-5UTRENST00000460856ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000460856ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000460856ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000460856ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000240874ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000240874ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-5UTRENST00000240874ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000240874ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000240874ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000240874ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000360013ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000360013ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-5UTRENST00000360013ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000360013ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000360013ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000360013ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000393496ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000393496ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-5UTRENST00000393496ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000393496ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000393496ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000393496ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000291478ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000291478ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-5UTRENST00000291478ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000291478ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000291478ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000291478ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000428018ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000428018ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-5UTRENST00000428018ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000428018ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000428018ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
5CDS-intronENST00000428018ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000459915ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000459915ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-5UTRENST00000459915ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000459915ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000459915ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000459915ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000462213ENST00000396299KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000462213ENST00000357727KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-5UTRENST00000462213ENST00000396300KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000462213ENST00000409603KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000462213ENST00000396298KALRNchr3

124352800

+CREB5chr7

28527793

+
intron-intronENST00000462213ENST00000482692KALRNchr3

124352800

+CREB5chr7

28527793

+

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FusionProtFeatures for KALRN_CREB5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KALRN

O60229

CREB5

Q02930

Promotes the exchange of GDP by GTP. Activates specificRho GTPase family members, thereby inducing various signalingmechanisms that regulate neuronal shape, growth, and plasticity,through their effects on the actin cytoskeleton. Induceslamellipodia independent of its GEF activity.{ECO:0000269|PubMed:10023074}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KALRN_CREB5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KALRN_CREB5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KALRNPAM, RAC1, ATXN7, CACNA1A, CDC5L, DISC1, DTNBP1, NDEL1, LNX1, FASLG, GNB1, COIL, GFI1B, SNCAIP, DICER1, SPTAN1CREB5CREB5, JUN, LGR4, TRIM23, COL8A1, FOS, FOSL2, KIFC3, KRT15, MDFI, TRAF2, TRIP6, FOSL1, RGS20, SPRY1, SPRY2, RBPMS, MTUS2, EFEMP2, ADAMTSL4, TSGA10, KRTAP4-12, KRTAP3-2, KRTAP9-2, KRTAP9-4, KRTAP4-2, RIMBP3, KRT40, MGAT5B, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-11, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, KRTAP5-6, BRCA1, ATF7, ATF2, JUND, BACH1, EWSR1, LGALS13, KRTAP5-9, JUNB, ARIH1, MLLT6, BATF3, PPP2R2D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KALRN_CREB5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KALRN_CREB5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKALRNC0041696Unipolar Depression1PSYGENET
HgeneKALRNC1269683Major Depressive Disorder1PSYGENET