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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18111

FusionGeneSummary for JUP_NRG3

check button Fusion gene summary
Fusion gene informationFusion gene name: JUP_NRG3
Fusion gene ID: 18111
HgeneTgene
Gene symbol

JUP

NRG3

Gene ID

3728

10718

Gene namejunction plakoglobinneuregulin 3
SynonymsCTNNG|DP3|DPIII|PDGB|PKGBHRG3|pro-NRG3
Cytomap

17q21.2

10q23.1

Type of geneprotein-codingprotein-coding
Descriptionjunction plakoglobincatenin (cadherin-associated protein), gamma 80kDadesmoplakin IIIdesmoplakin-3pro-neuregulin-3, membrane-bound isoformneuregulin 3 variant 1neuregulin 3 variant 10neuregulin 3 variant 11neuregulin 3 variant 12neuregulin 3 variant 13neuregulin 3 variant 14neuregulin 3 variant 3neuregulin 3 variant 4neuregulin 3 variant 5ne
Modification date2018052320180523
UniProtAcc

P14923

P56975

Ensembl transtripts involved in fusion geneENST00000540235, ENST00000393930, 
ENST00000393931, ENST00000310706, 
ENST00000372141, ENST00000404547, 
ENST00000372142, ENST00000404576, 
ENST00000556918, ENST00000537893, 
ENST00000545131, 
Fusion gene scores* DoF score18 X 17 X 8=24486 X 5 X 5=150
# samples 216
** MAII scorelog2(21/2448*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JUP [Title/Abstract] AND NRG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJUP

GO:0002159

desmosome assembly

22889254

HgeneJUP

GO:0042127

regulation of cell proliferation

17924338

HgeneJUP

GO:0042307

positive regulation of protein import into nucleus

10825188|14661054

HgeneJUP

GO:0050982

detection of mechanical stimulus

18937352

HgeneJUP

GO:0051091

positive regulation of DNA binding transcription factor activity

14661054

HgeneJUP

GO:0071681

cellular response to indole-3-methanol

10868478

HgeneJUP

GO:0098609

cell-cell adhesion

18937352


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF826653JUPchr17

39847509

-NRG3chr10

83842520

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000540235ENST00000372141JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000404547JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000372142JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000404576JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000556918JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000537893JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000540235ENST00000545131JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000372141JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000404547JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000372142JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000404576JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000556918JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000537893JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393930ENST00000545131JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000372141JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000404547JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000372142JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000404576JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000556918JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000537893JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000393931ENST00000545131JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000372141JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000404547JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000372142JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000404576JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000556918JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000537893JUPchr17

39847509

-NRG3chr10

83842520

+
intron-intronENST00000310706ENST00000545131JUPchr17

39847509

-NRG3chr10

83842520

+

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FusionProtFeatures for JUP_NRG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JUP

P14923

NRG3

P56975

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an importantstrategic position to influence the arrangement and function ofboth the cytoskeleton and the cells within the tissue. Thepresence of plakoglobin in both the desmosomes and in theintermediate junctions suggests that it plays a central role inthe structure and function of submembranous plaques. Acts as asubstrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-cateninin E-cadherin/catenin adhesion complexes which are proposed tocouple cadherins to the actin cytoskeleton (By similarity).{ECO:0000250}. Direct ligand for the ERBB4 tyrosine kinase receptor.Binding results in ligand-stimulated tyrosine phosphorylation andactivation of the receptor. Does not bind to the EGF receptor,ERBB2 or ERBB3 receptors. May be a survival factor foroligodendrocytes. {ECO:0000269|PubMed:16478787,ECO:0000269|PubMed:9275162}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JUP_NRG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JUP_NRG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JUP_NRG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneJUPP14923DB01593ZincJunction plakoglobinsmall moleculeapproved|investigational

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RelatedDiseases for JUP_NRG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJUPC0023895Liver diseases1CTD_human
HgeneJUPC0033578Prostatic Neoplasms1CTD_human
HgeneJUPC0232347No-Reflow Phenomenon1CTD_human
HgeneJUPC1969081Arrhythmogenic Right Ventricular Dysplasia, Familial, 121CTD_human;UNIPROT
TgeneNRG3C0005586Bipolar Disorder2PSYGENET
TgeneNRG3C0036341Schizophrenia1CTD_human
TgeneNRG3C0853193Bipolar I disorder1PSYGENET