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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18094

FusionGeneSummary for JUND_NASP

check button Fusion gene summary
Fusion gene informationFusion gene name: JUND_NASP
Fusion gene ID: 18094
HgeneTgene
Gene symbol

JUND

NASP

Gene ID

3727

4678

Gene nameJunD proto-oncogene, AP-1 transcription factor subunitnuclear autoantigenic sperm protein
SynonymsAP-1FLB7527|HMDRA1|PRO1999
Cytomap

19p13.11

1p34.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor jun-DJunD-FL isoformactivator protein 1jun D proto-oncogenenuclear autoantigenic sperm proteinNASP histone chaperonehistone H1-binding proteinnuclear autoantigenic sperm protein (histone-binding)
Modification date2018052320180523
UniProtAcc

P17535

P49321

Ensembl transtripts involved in fusion geneENST00000252818, ENST00000402363, 
ENST00000537798, ENST00000350030, 
ENST00000372052, ENST00000351223, 
ENST00000530073, 
Fusion gene scores* DoF score4 X 4 X 1=167 X 8 X 4=224
# samples 510
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JUND [Title/Abstract] AND NASP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJUND

GO:0045944

positive regulation of transcription by RNA polymerase II

10508860

TgeneNASP

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneNASP

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC080632JUNDchr19

18391459

-NASPchr1

46067972

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000252818ENST00000402363JUNDchr19

18391459

-NASPchr1

46067972

+
intron-intronENST00000252818ENST00000537798JUNDchr19

18391459

-NASPchr1

46067972

+
intron-intronENST00000252818ENST00000350030JUNDchr19

18391459

-NASPchr1

46067972

+
intron-intronENST00000252818ENST00000372052JUNDchr19

18391459

-NASPchr1

46067972

+
intron-intronENST00000252818ENST00000351223JUNDchr19

18391459

-NASPchr1

46067972

+
intron-intronENST00000252818ENST00000530073JUNDchr19

18391459

-NASPchr1

46067972

+

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FusionProtFeatures for JUND_NASP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JUND

P17535

NASP

P49321

Transcription factor binding AP-1 sites.{ECO:0000269|PubMed:9989505}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JUND_NASP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JUND_NASP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JUND_NASP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for JUND_NASP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJUNDC0017658Glomerulonephritis1CTD_human
HgeneJUNDC0023890Liver Cirrhosis1CTD_human
HgeneJUNDC0038220Status Epilepticus1CTD_human
HgeneJUNDC0236736Cocaine-Related Disorders1CTD_human
HgeneJUNDC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human