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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 18067

FusionGeneSummary for JMJD1C_GABPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: JMJD1C_GABPB1
Fusion gene ID: 18067
HgeneTgene
Gene symbol

JMJD1C

GABPB1

Gene ID

221037

2553

Gene namejumonji domain containing 1CGA binding protein transcription factor subunit beta 1
SynonymsKDM3C|TRIP-8|TRIP8BABPB2|E4TF1|E4TF1-47|E4TF1-53|E4TF1B|GABPB|GABPB-1|GABPB2|NRF2B1|NRF2B2
Cytomap

10q21.3

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionprobable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8GA-binding protein subunit beta-1GA binding protein transcription factor beta subunit 1 transcript variant gamma-2GABP subunit beta-2nuclear respiratory factor 2transcription factor E4TF1-47transcription factor E4TF1-53
Modification date2018052320180519
UniProtAcc

Q15652

Q06547

Ensembl transtripts involved in fusion geneENST00000399262, ENST00000402544, 
ENST00000399251, ENST00000542921, 
ENST00000489372, 		ENST00000380877, 
ENST00000220429, ENST00000543881, 
ENST00000429662, ENST00000396464, 
ENST00000359031, ENST00000560825, 
Fusion gene scores* DoF score13 X 8 X 6=6241 X 1 X 1=1
# samples 131
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: JMJD1C [Title/Abstract] AND GABPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGABPB1

GO:0045944

positive regulation of transcription by RNA polymerase II

9857059


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03P-01AJMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000399262ENST00000380877JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
In-frameENST00000399262ENST00000220429JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5CDS-intronENST00000399262ENST00000543881JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5CDS-intronENST00000399262ENST00000429662JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5CDS-intronENST00000399262ENST00000396464JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5CDS-intronENST00000399262ENST00000359031JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5CDS-intronENST00000399262ENST00000560825JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000402544ENST00000380877JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000402544ENST00000220429JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000402544ENST00000543881JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000402544ENST00000429662JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000402544ENST00000396464JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000402544ENST00000359031JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000402544ENST00000560825JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-3CDSENST00000399251ENST00000380877JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-3CDSENST00000399251ENST00000220429JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-intronENST00000399251ENST00000543881JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-intronENST00000399251ENST00000429662JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-intronENST00000399251ENST00000396464JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-intronENST00000399251ENST00000359031JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
5UTR-intronENST00000399251ENST00000560825JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000542921ENST00000380877JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000542921ENST00000220429JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000542921ENST00000543881JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000542921ENST00000429662JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000542921ENST00000396464JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000542921ENST00000359031JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000542921ENST00000560825JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000489372ENST00000380877JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-3CDSENST00000489372ENST00000220429JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000489372ENST00000543881JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000489372ENST00000429662JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000489372ENST00000396464JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000489372ENST00000359031JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-
intron-intronENST00000489372ENST00000560825JMJD1Cchr10

65225255

-GABPB1chr15

50601995

-

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FusionProtFeatures for JMJD1C_GABPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JMJD1C

Q15652

GABPB1

Q06547

Transcription factor capable of interacting with purinerich repeats (GA repeats). Necessary for the expression of theAdenovirus E4 gene. {ECO:0000269|PubMed:10675337,ECO:0000269|PubMed:8816484}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGABPB1chr10:65225255chr15:50601995ENST00000220429-09103_1320396RepeatNote=ANK 4
TgeneGABPB1chr10:65225255chr15:50601995ENST00000220429-09136_1660396RepeatNote=ANK 5
TgeneGABPB1chr10:65225255chr15:50601995ENST00000220429-0937_660396RepeatNote=ANK 2
TgeneGABPB1chr10:65225255chr15:50601995ENST00000220429-095_340396RepeatNote=ANK 1
TgeneGABPB1chr10:65225255chr15:50601995ENST00000220429-0970_990396RepeatNote=ANK 3
TgeneGABPB1chr10:65225255chr15:50601995ENST00000359031-19103_1320349RepeatNote=ANK 4
TgeneGABPB1chr10:65225255chr15:50601995ENST00000359031-19136_1660349RepeatNote=ANK 5
TgeneGABPB1chr10:65225255chr15:50601995ENST00000359031-1937_660349RepeatNote=ANK 2
TgeneGABPB1chr10:65225255chr15:50601995ENST00000359031-195_340349RepeatNote=ANK 1
TgeneGABPB1chr10:65225255chr15:50601995ENST00000359031-1970_990349RepeatNote=ANK 3
TgeneGABPB1chr10:65225255chr15:50601995ENST00000380877-09103_1320384RepeatNote=ANK 4
TgeneGABPB1chr10:65225255chr15:50601995ENST00000380877-09136_1660384RepeatNote=ANK 5
TgeneGABPB1chr10:65225255chr15:50601995ENST00000380877-0937_660384RepeatNote=ANK 2
TgeneGABPB1chr10:65225255chr15:50601995ENST00000380877-095_340384RepeatNote=ANK 1
TgeneGABPB1chr10:65225255chr15:50601995ENST00000380877-0970_990384RepeatNote=ANK 3
TgeneGABPB1chr10:65225255chr15:50601995ENST00000396464-08103_1320349RepeatNote=ANK 4
TgeneGABPB1chr10:65225255chr15:50601995ENST00000396464-08136_1660349RepeatNote=ANK 5
TgeneGABPB1chr10:65225255chr15:50601995ENST00000396464-0837_660349RepeatNote=ANK 2
TgeneGABPB1chr10:65225255chr15:50601995ENST00000396464-085_340349RepeatNote=ANK 1
TgeneGABPB1chr10:65225255chr15:50601995ENST00000396464-0870_990349RepeatNote=ANK 3
TgeneGABPB1chr10:65225255chr15:50601995ENST00000429662-08103_1320361RepeatNote=ANK 4
TgeneGABPB1chr10:65225255chr15:50601995ENST00000429662-08136_1660361RepeatNote=ANK 5
TgeneGABPB1chr10:65225255chr15:50601995ENST00000429662-0837_660361RepeatNote=ANK 2
TgeneGABPB1chr10:65225255chr15:50601995ENST00000429662-085_340361RepeatNote=ANK 1
TgeneGABPB1chr10:65225255chr15:50601995ENST00000429662-0870_990361RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399251-1252274_2498-163477DomainJmjC
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399262-1262274_2498562541DomainJmjC
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000542921-1252274_2498-2062359DomainJmjC
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399251-1252066_2070-163477MotifNote=LXXLL motif
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399262-1262066_2070562541MotifNote=LXXLL motif
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000542921-1252066_2070-2062359MotifNote=LXXLL motif
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399251-1251846_1871-163477Zinc fingerC6-type
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000399262-1261846_1871562541Zinc fingerC6-type
HgeneJMJD1Cchr10:65225255chr15:50601995ENST00000542921-1251846_1871-2062359Zinc fingerC6-type


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FusionGeneSequence for JMJD1C_GABPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000380877_chr15_50601995_-_440aa
MAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAMSLVDLGKKLLEAARAGQDDEVRILMANGAPFTT
DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI
KYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLAT
LAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIA

>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000220429_chr15_50601995_-_452aa
MAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAMSLVDLGKKLLEAARAGQDDEVRILMANGAPFTT
DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI
KYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAV
QFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDG
QQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000380877_chr15_50601995_-_1320nt
ATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTGGCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGC
GGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACACAGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTA
GATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAAGTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACA
GACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTATTCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGA
GATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAGGGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGT
GCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCCACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATC
AAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTTGATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAG
ATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCTGACACTGTGACAATACATGCTGCAACACCACAGTTTATC
ATTGGACCTGGAGGGGTGGTGAACCTAACAGATGAAACGGGTGTATCTGCTGTTCAGTTTGGAAACTCTTCTACATCAGTATTAGCTACA
TTAGCTGCCTTAGCTGAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACTCCAGTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCT
GTGGATGGTGCCATTCAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATCACAATAGTTACAGATGGAATTCAGCTTGGAAATTTGCAC
TCTATTCCAACCAGTGGAATTGGTCAGCCCATCATTGTGACCATGCCAGATGGACAACAAGTATTAACAGTACCAGCAACAGACATTGCT
GAAGAAACTGTTATAAGTGAAGAACCACCAGCTAAGAGACAATGTATCGAAATAATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAG
AGAGAAGCTCTTCAGAAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAATATCGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAG

>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000220429_chr15_50601995_-_1356nt
ATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTGGCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGC
GGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACACAGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTA
GATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAAGTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACA
GACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTATTCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGA
GATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAGGGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGT
GCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCCACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATC
AAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTTGATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAG
ATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCTGACACTGTGACAATACATGCTGCAACACCACAGTTTATC
ATTGGACCTGGAGGGGTGGTGAACCTAACAGGTCTGGTATCTTCAGAAAATTCATCCAAGGCAACAGATGAAACGGGTGTATCTGCTGTT
CAGTTTGGAAACTCTTCTACATCAGTATTAGCTACATTAGCTGCCTTAGCTGAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACTCCA
GTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCTGTGGATGGTGCCATTCAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATCACA
ATAGTTACAGATGGAATTCAGCTTGGAAATTTGCACTCTATTCCAACCAGTGGAATTGGTCAGCCCATCATTGTGACCATGCCAGATGGA
CAACAAGTATTAACAGTACCAGCAACAGACATTGCTGAAGAAACTGTTATAAGTGAAGAACCACCAGCTAAGAGACAATGTATCGAAATA
ATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAGAGAGAAGCTCTTCAGAAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAATAT
CGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAGGCCTACAGACAGAAGTTGGAAGCTATGACTCGTCTTCAGACTAATAAAGAAGCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000380877_chr15_50601995_-_2979nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTAGATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAA
GTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACAGACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTAT
TCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGAGATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAG
GGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGTGCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCC
ACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATCAAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTT
GATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAGATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCT
GACACTGTGACAATACATGCTGCAACACCACAGTTTATCATTGGACCTGGAGGGGTGGTGAACCTAACAGATGAAACGGGTGTATCTGCT
GTTCAGTTTGGAAACTCTTCTACATCAGTATTAGCTACATTAGCTGCCTTAGCTGAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACT
CCAGTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCTGTGGATGGTGCCATTCAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATC
ACAATAGTTACAGATGGAATTCAGCTTGGAAATTTGCACTCTATTCCAACCAGTGGAATTGGTCAGCCCATCATTGTGACCATGCCAGAT
GGACAACAAGTATTAACAGTACCAGCAACAGACATTGCTGAAGAAACTGTTATAAGTGAAGAACCACCAGCTAAGAGACAATGTATCGAA
ATAATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAGAGAGAAGCTCTTCAGAAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAA
TATCGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAGGCCTACAGACAGAAGTTGGAAGCTATGACTCGTCTTCAGACTAATAAAGAA
GCTGTTTAATTGAAATGAACATGTAGTTTGATTTTACTTTTGGTCAAGAAAGAATACAATCTTGAACTGTACACAACAAAGGTACAGCCA
TGGGAATACAGAATGATAGAAGAGACTACAGATGGATAATTGGACTTAAGCCATGAGCTCTGAGTTCTTGTAACATAAAACTTTACTTTA
GAAGTTGTGAAATGTATTTAAAACTGAATTCTGTAAATAGTTTTTTTTTTTTTACAGTTCCAAATGAGTTGATAAAGATTGTTGAAGAGA
TCCAAAACCAGAATAAGCCACTGTTTTTGTGAATTCTTTTTGATTTTAGTACAAACCTTAATTTCTCAGAAACGGAACAGTTTTAAGGGT
GATCGTTGTTGGTTAGGCCAAATGTTGTGTAATAATTATGGTGGACTGATGCTGGAATTACTCCTGTAGGTATAAACCTCTGTATGAAGA
GAAGATTTCTCCCAGGAAATCTTTGTACAGCTTTAAGTTGTGTCAGATTCTCTGAAAACATTTTTTAGAAAGCAAAATTTTTATATTTGT
TCAATTTCAGCTATACCCAAGTAGATTTACATGTATATGAAGCAAATATTTTTAAAAATTTCTGTTTGTACATATTCTGCATGTTTTATA
ATTTCAAAATGCATCACTTACATAGGTATTTCTCCCACAGAAATGATGAAAGTGACCAGAAAAAAACAAAAACAAAACCCCTTTACTCTG
TAGGTCATTGAAACGAAGTAAGCTGGCAGCTGGTTTTATTGGAATGACAGTGTTCTCGGAAGGAGCAGCCTACAAGATAACTTGAATTTG
CCAATTCTGCAAAATCTGTGCTTTTTTGAAAATTTAAGAGTGGGGACGTGAAACTGTATTCTGTGCCTTCCATCATGATTTCCACATGAA
AGCACTTTAAGGCACTGATTTTAAGATAATGTTTTTGGAAAACCCAATGCATATGGGTTTCTGAAATATTTTATGGACTTATTTCTCCCC
AGGAAATGATTCTTACGGAAAAAAATTGCTTTTGTATGTAGAACAGGAACTTTTTGTATTACAGTGATGCAATAGACATGTCTAATGTAA
CTTCTACTTTTCCTTTTGAAAGCTCAGTGTCTGTGCTATGACTTGCTCTCATCACAATATTGTTGAATTCCACAATGTATGGACATTAAA
CACTGGCAGACTGTTCACTTTTTCTTTTTTTTTTTTGGTAAAATATTACTTCAAACCCCTTTTTCTTGCTTTATTTTTCAGTGTTTTATT
GCTTTATGAACTGTTTAACCCTGAAATCCCTCTAGGTTATCTATACTGTATAAAAAAGCAATTACCCTTAAAACTGTACTCTGGCCTACT
TTTCTATTTTGCAATTAAATATCTTTTTCACATATGTTCATTGTAGACTTATGTTTTTATCACATCTTATTAACACATTAAAAATGTTAT

>In-frame_JMJD1C_ENST00000399262_chr10_65225255_-_GABPB1_ENST00000220429_chr15_50601995_-_2944nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTAGATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAA
GTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACAGACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTAT
TCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGAGATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAG
GGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGTGCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCC
ACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATCAAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTT
GATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAGATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCT
GACACTGTGACAATACATGCTGCAACACCACAGTTTATCATTGGACCTGGAGGGGTGGTGAACCTAACAGGTCTGGTATCTTCAGAAAAT
TCATCCAAGGCAACAGATGAAACGGGTGTATCTGCTGTTCAGTTTGGAAACTCTTCTACATCAGTATTAGCTACATTAGCTGCCTTAGCT
GAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACTCCAGTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCTGTGGATGGTGCCATT
CAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATCACAATAGTTACAGATGGAATTCAGCTTGGAAATTTGCACTCTATTCCAACCAGT
GGAATTGGTCAGCCCATCATTGTGACCATGCCAGATGGACAACAAGTATTAACAGTACCAGCAACAGACATTGCTGAAGAAACTGTTATA
AGTGAAGAACCACCAGCTAAGAGACAATGTATCGAAATAATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAGAGAGAAGCTCTTCAG
AAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAATATCGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAGGCCTACAGACAGAAG
TTGGAAGCTATGACTCGTCTTCAGACTAATAAAGAAGCTGTTTAATTGAAATGAACATGTAGTTTGATTTTACTTTTGGTCAAGAAAGAA
TACAATCTTGAACTGTACACAACAAAGGTACAGCCATGGGAATACAGAATGATAGAAGAGACTACAGATGGATAATTGGACTTAAGCCAT
GAGCTCTGAGTTCTTGTAACATAAAACTTTACTTTAGAAGTTGTGAAATGTATTTAAAACTGAATTCTGTAAATAGTTTTTTTTTTTTTA
CAGTTCCAAATGAGTTGATAAAGATTGTTGAAGAGATCCAAAACCAGAATAAGCCACTGTTTTTGTGAATTCTTTTTGATTTTAGTACAA
ACCTTAATTTCTCAGAAACGGAACAGTTTTAAGGGTGATCGTTGTTGGTTAGGCCAAATGTTGTGTAATAATTATGGTGGACTGATGCTG
GAATTACTCCTGTAGGTATAAACCTCTGTATGAAGAGAAGATTTCTCCCAGGAAATCTTTGTACAGCTTTAAGTTGTGTCAGATTCTCTG
AAAACATTTTTTAGAAAGCAAAATTTTTATATTTGTTCAATTTCAGCTATACCCAAGTAGATTTACATGTATATGAAGCAAATATTTTTA
AAAATTTCTGTTTGTACATATTCTGCATGTTTTATAATTTCAAAATGCATCACTTACATAGGTATTTCTCCCACAGAAATGATGAAAGTG
ACCAGAAAAAAACAAAAACAAAACCCCTTTACTCTGTAGGTCATTGAAACGAAGTAAGCTGGCAGCTGGTTTTATTGGAATGACAGTGTT
CTCGGAAGGAGCAGCCTACAAGATAACTTGAATTTGCCAATTCTGCAAAATCTGTGCTTTTTTGAAAATTTAAGAGTGGGGACGTGAAAC
TGTATTCTGTGCCTTCCATCATGATTTCCACATGAAAGCACTTTAAGGCACTGATTTTAAGATAATGTTTTTGGAAAACCCAATGCATAT
GGGTTTCTGAAATATTTTATGGACTTATTTCTCCCCAGGAAATGATTCTTACGGAAAAAAATTGCTTTTGTATGTAGAACAGGAACTTTT
TGTATTACAGTGATGCAATAGACATGTCTAATGTAACTTCTACTTTTCCTTTTGAAAGCTCAGTGTCTGTGCTATGACTTGCTCTCATCA
CAATATTGTTGAATTCCACAATGTATGGACATTAAACACTGGCAGACTGTTCACTTTTTCTTTTTTTTTTTTGGTAAAATATTACTTCAA
ACCCCTTTTTCTTGCTTTATTTTTCAGTGTTTTATTGCTTTATGAACTGTTTAACCCTGAAATCCCTCTAGGTTATCTATACTGTATAAA


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FusionGenePPI for JMJD1C_GABPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
JMJD1CVHL, ESR2, PPARG, NUDT21, TK1, GADD45A, AR, RNF8, RNF168, MT2A, PSMC1, SRPK2, RBPJ, NR3C1, TXNIPGABPB1FANCG, USO1, LMO3, MAGEB18, TDRD7, CIC, GABPA, DHX16, IL16, RYBP, YAF2, YY1, LMO1, SNRPA, SNRPB2, TRAF2, LMO4, POGZ, RSPH14, RBM11, FAM90A1, ZDHHC17, TPD52L2, GSTP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JMJD1C_GABPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for JMJD1C_GABPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJMJD1CC0004352Autistic Disorder1CTD_human
HgeneJMJD1CC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneJMJD1CC3495559Juvenile arthritis1CTD_human