FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18053

FusionGeneSummary for JDP2_FLVCR2

check button Fusion gene summary
Fusion gene informationFusion gene name: JDP2_FLVCR2
Fusion gene ID: 18053
HgeneTgene
Gene symbol

JDP2

FLVCR2

Gene ID

122953

55640

Gene nameJun dimerization protein 2feline leukemia virus subgroup C cellular receptor family member 2
SynonymsJUNDM2C14orf58|CCT|EPV|FLVCRL14q|MFSD7C|PVHH
Cytomap

14q24.3

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionjun dimerization protein 2progesterone receptor co-activatorfeline leukemia virus subgroup C receptor-related protein 2calcium-chelate transporter
Modification date2018052320180523
UniProtAcc

Q8WYK2

Q9UPI3

Ensembl transtripts involved in fusion geneENST00000419727, ENST00000559773, 
ENST00000437176, ENST00000435893, 
ENST00000267569, 		ENST00000238667, 
ENST00000539311, ENST00000556241, 
ENST00000553587, ENST00000556856, 
ENST00000555027, 
Fusion gene scores* DoF score4 X 3 X 4=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: JDP2 [Title/Abstract] AND FLVCR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-66-2793-01AJDP2chr14

75899039

+FLVCR2chr14

76088422

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000419727ENST00000238667JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000419727ENST00000539311JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3UTRENST00000419727ENST00000556241JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-5UTRENST00000419727ENST00000553587JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000419727ENST00000556856JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000419727ENST00000555027JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000559773ENST00000238667JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000559773ENST00000539311JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3UTRENST00000559773ENST00000556241JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-5UTRENST00000559773ENST00000553587JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000559773ENST00000556856JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000559773ENST00000555027JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000437176ENST00000238667JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000437176ENST00000539311JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3UTRENST00000437176ENST00000556241JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-5UTRENST00000437176ENST00000553587JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000437176ENST00000556856JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000437176ENST00000555027JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000435893ENST00000238667JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3CDSENST00000435893ENST00000539311JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-3UTRENST00000435893ENST00000556241JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-5UTRENST00000435893ENST00000553587JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000435893ENST00000556856JDP2chr14

75899039

+FLVCR2chr14

76088422

+
intron-intronENST00000435893ENST00000555027JDP2chr14

75899039

+FLVCR2chr14

76088422

+
Frame-shiftENST00000267569ENST00000238667JDP2chr14

75899039

+FLVCR2chr14

76088422

+
Frame-shiftENST00000267569ENST00000539311JDP2chr14

75899039

+FLVCR2chr14

76088422

+
5CDS-3UTRENST00000267569ENST00000556241JDP2chr14

75899039

+FLVCR2chr14

76088422

+
5CDS-5UTRENST00000267569ENST00000553587JDP2chr14

75899039

+FLVCR2chr14

76088422

+
5CDS-intronENST00000267569ENST00000556856JDP2chr14

75899039

+FLVCR2chr14

76088422

+
5CDS-intronENST00000267569ENST00000555027JDP2chr14

75899039

+FLVCR2chr14

76088422

+

Top

FusionProtFeatures for JDP2_FLVCR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JDP2

Q8WYK2

FLVCR2

Q9UPI3

Component of the AP-1 transcription factor thatrepresses transactivation mediated by the Jun family of proteins.Involved in a variety of transcriptional responses associated withAP-1 such as UV-induced apoptosis, cell differentiation,tumorigenesis and antitumogeneris. Can also function as arepressor by recruiting histone deacetylase 3/HDAC3 to thepromoter region of JUN. May control transcription via directregulation of the modification of histones and the assembly ofchromatin. {ECO:0000269|PubMed:12707301,ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868,ECO:0000269|PubMed:16518400}. Acts as an importer of heme. Also acts as a transporterfor a calcium-chelator complex, important for growth and calciummetabolism. {ECO:0000269|PubMed:20823265}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for JDP2_FLVCR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for JDP2_FLVCR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
JDP2IRF2BP1, ATF7, JUND, JUN, ATF2, GTF2H1, JDP2, PGR, ELAVL1, HDAC6, HDAC10, HDAC1, HDAC4, HDAC5, TRIM25FLVCR2SHMT2, NXF1, EPN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for JDP2_FLVCR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for JDP2_FLVCR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJDP2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneJDP2C2239176Liver carcinoma1CTD_human
TgeneFLVCR2C1856972Encephaloclastic Proliferative Vasculopathy3CTD_human;UNIPROT