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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18039

FusionGeneSummary for JAZF1-AS1_ABLIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: JAZF1-AS1_ABLIM1
Fusion gene ID: 18039
HgeneTgene
Gene symbol

JAZF1-AS1

ABLIM1

Gene ID

100128081

3983

Gene nameJAZF1 antisense RNA 1actin binding LIM protein 1
Synonyms-ABLIM|LIMAB1|LIMATIN|abLIM-1
Cytomap

7p15.1

10q25.3

Type of genencRNAprotein-coding
DescriptionJAZF1 antisense RNA 1 (non-protein coding)actin-binding LIM protein 1actin-binding LIM protein family member 1actin-binding double-zinc-finger protein
Modification date2018032920180523
UniProtAcc

O14639

Ensembl transtripts involved in fusion geneENST00000455963, ENST00000436758, 
ENST00000444500, 
ENST00000369252, 
ENST00000533213, ENST00000277895, 
ENST00000369266, ENST00000392952, 
ENST00000369253, ENST00000477638, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 3=147
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JAZF1-AS1 [Title/Abstract] AND ABLIM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI037108JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000455963ENST00000369252JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000533213JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000277895JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000369266JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000392952JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000369253JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000455963ENST00000477638JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000369252JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000533213JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000277895JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000369266JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000392952JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000369253JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000436758ENST00000477638JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000369252JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000533213JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000277895JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000369266JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000392952JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000369253JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-
intron-intronENST00000444500ENST00000477638JAZF1-AS1chr7

28269062

-ABLIM1chr10

116273615

-

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FusionProtFeatures for JAZF1-AS1_ABLIM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JAZF1-AS1

ABLIM1

O14639

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JAZF1-AS1_ABLIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JAZF1-AS1_ABLIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JAZF1-AS1_ABLIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for JAZF1-AS1_ABLIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABLIM1C0236969Substance-Related Disorders1CTD_human