FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18004

FusionGeneSummary for JAGN1_ZC3H4

check button Fusion gene summary
Fusion gene informationFusion gene name: JAGN1_ZC3H4
Fusion gene ID: 18004
HgeneTgene
Gene symbol

JAGN1

ZC3H4

Gene ID

84522

23211

Gene namejagunal homolog 1zinc finger CCCH-type containing 4
SynonymsGL009|SCN6C19orf7
Cytomap

3p25.3

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionprotein jagunal homolog 1zinc finger CCCH domain-containing protein 4
Modification date2018051920180523
UniProtAcc

Q8N5M9

Q9UPT8

Ensembl transtripts involved in fusion geneENST00000307768, ENST00000489724, 
ENST00000253048, ENST00000594019, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 6 X 4=96
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JAGN1 [Title/Abstract] AND ZC3H4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-14-0817-01AJAGN1chr3

9934710

+ZC3H4chr19

47589795

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000307768ENST00000253048JAGN1chr3

9934710

+ZC3H4chr19

47589795

-
5CDS-intronENST00000307768ENST00000594019JAGN1chr3

9934710

+ZC3H4chr19

47589795

-
intron-3CDSENST00000489724ENST00000253048JAGN1chr3

9934710

+ZC3H4chr19

47589795

-
intron-intronENST00000489724ENST00000594019JAGN1chr3

9934710

+ZC3H4chr19

47589795

-

Top

FusionProtFeatures for JAGN1_ZC3H4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JAGN1

Q8N5M9

ZC3H4

Q9UPT8

Endoplasmic reticulum transmembrane protein involved invesicle-mediated transport, which is required for neutrophilfunction. Required for vesicle-mediated transport; it is howeverunclear whether it is involved in early secretory pathway orintracellular protein transport. Acts as a regulator of neutrophilfunction, probably via its role in vesicle-mediated transport:required for defense against fungal pathogens and for granulocytecolony-stimulating factor (GM-CSF) signaling pathway; possibly byregulating glycosylation and/or targeting of proteins contributingto the viability and migration of neutrophils.{ECO:0000269|PubMed:25129144, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for JAGN1_ZC3H4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for JAGN1_ZC3H4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
JAGN1APP, VKORC1, CLEC7A, CREB3L1, CCDC155, DDOST, SCAMP2, TECR, SEC61A1, VDAC2, VDAC3, TCTN2, TCTN3, TMEM216, LMNAZC3H4MRPL45, USP28, DBN1, WIZ, SDHA, FLNB, SHMT1, PSMA2, MARC1, DYNC1H1, PAF1, SLC25A10, OBSL1, RNF2, BMI1, RSPH9, ZFP41, NTRK1, CDC42, RC3H1, EGFR, CAPN13, JMJD6, HTRA4, PDGFB, MRPS11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for JAGN1_ZC3H4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for JAGN1_ZC3H4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJAGN1C0027947Neutropenia2CTD_human
HgeneJAGN1C4014954NEUTROPENIA, SEVERE CONGENITAL, 6, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT