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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 17893

FusionGeneSummary for ITGB6_RBMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB6_RBMS1
Fusion gene ID: 17893
HgeneTgene
Gene symbol

ITGB6

RBMS1

Gene ID

3694

5937

Gene nameintegrin subunit beta 6RNA binding motif single stranded interacting protein 1
SynonymsAI1HC2orf12|HCC-4|MSSP|MSSP-1|MSSP-2|MSSP-3|SCR2|YC1
Cytomap

2q24.2

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-6integrin, beta 6RNA-binding motif, single-stranded-interacting protein 1c-myc gene single strand binding protein 2cervical cancer oncogene 4single-stranded DNA-binding protein MSSP-1suppressor of CDC2 with RNA-binding motif 2suppressor of cdc 2 (cdc13) with RNA bind
Modification date2018052320180523
UniProtAcc

P18564

P29558

Ensembl transtripts involved in fusion geneENST00000283249, ENST00000485635, 
ENST00000428609, ENST00000409967, 
ENST00000409872, 
ENST00000474820, 
ENST00000348849, ENST00000409075, 
ENST00000409289, ENST00000392753, 
ENST00000409972, 
Fusion gene scores* DoF score6 X 7 X 6=2524 X 8 X 5=160
# samples 119
** MAII scorelog2(11/252*10)=-1.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/160*10)=-0.830074998557688
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB6 [Title/Abstract] AND RBMS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB6

GO:0033627

cell adhesion mediated by integrin

17158881


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-BT-A20W-01AITGB6chr2

161051880

-RBMS1chr2

161174738

-
TCGARVBLCATCGA-ZF-A9R1-01AITGB6chr2

160998493

-RBMS1chr2

161143595

-
TCGARVBLCATCGA-ZF-AA51-01AITGB6chr2

161025723

-RBMS1chr2

161133894

-
TCGARVBRCATCGA-D8-A1XK-01AITGB6chr2

161030485

-RBMS1chr2

161159998

-
TCGARVHNSCTCGA-D6-8568-01AITGB6chr2

161051880

-RBMS1chr2

161174738

-
TCGARVLUSCTCGA-22-1005-01AITGB6chr2

161055690

-RBMS1chr2

161141555

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283249ENST00000474820ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000348849ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000409075ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000409289ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000392753ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000409972ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000474820ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000348849ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000409075ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000409289ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000392753ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5UTR-5UTRENST00000485635ENST00000409972ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000474820ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000348849ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000409075ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000409289ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000392753ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000428609ENST00000409972ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000474820ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000348849ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000409075ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000409289ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000392753ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409967ENST00000409972ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000474820ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000348849ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000409075ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000409289ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000392753ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000409872ENST00000409972ITGB6chr2

161051880

-RBMS1chr2

161174738

-
5CDS-5UTRENST00000283249ENST00000474820ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000348849ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000409075ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000409289ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000392753ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000409972ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000474820ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000348849ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000409075ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000409289ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000392753ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000485635ENST00000409972ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000474820ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000348849ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000409075ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000409289ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000392753ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000428609ENST00000409972ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000474820ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000348849ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000409075ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000409289ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000392753ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409967ENST00000409972ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000474820ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000348849ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000409075ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000409289ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000392753ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000409872ENST00000409972ITGB6chr2

160998493

-RBMS1chr2

161143595

-
5CDS-5UTRENST00000283249ENST00000474820ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000348849ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000409075ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000409289ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000392753ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000409972ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000474820ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000348849ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000409075ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000409289ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000392753ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5UTR-5UTRENST00000485635ENST00000409972ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000474820ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000348849ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000409075ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000409289ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000392753ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000428609ENST00000409972ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000474820ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000348849ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000409075ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000409289ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000392753ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409967ENST00000409972ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000474820ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000348849ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000409075ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000409289ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000392753ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000409872ENST00000409972ITGB6chr2

161025723

-RBMS1chr2

161133894

-
5CDS-5UTRENST00000283249ENST00000474820ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000348849ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000409075ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000409289ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000392753ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000409972ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000474820ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000348849ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000409075ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000409289ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000392753ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5UTR-5UTRENST00000485635ENST00000409972ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000474820ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000348849ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000409075ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000409289ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000392753ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000428609ENST00000409972ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000474820ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000348849ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000409075ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000409289ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000392753ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409967ENST00000409972ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000474820ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000348849ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000409075ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000409289ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000392753ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000409872ENST00000409972ITGB6chr2

161030485

-RBMS1chr2

161159998

-
5CDS-5UTRENST00000283249ENST00000474820ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000283249ENST00000348849ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000283249ENST00000409075ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000283249ENST00000409289ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000283249ENST00000392753ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000283249ENST00000409972ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000474820ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000348849ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000409075ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000409289ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000392753ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000485635ENST00000409972ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000474820ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000348849ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000409075ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000409289ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000392753ITGB6chr2

161055690

-RBMS1chr2

161141555

-
intron-5UTRENST00000428609ENST00000409972ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000474820ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000348849ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000409075ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000409289ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000392753ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409967ENST00000409972ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000474820ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000348849ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000409075ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000409289ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000392753ITGB6chr2

161055690

-RBMS1chr2

161141555

-
5CDS-5UTRENST00000409872ENST00000409972ITGB6chr2

161055690

-RBMS1chr2

161141555

-

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FusionProtFeatures for ITGB6_RBMS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB6

P18564

RBMS1

P29558

Integrin alpha-V/beta-6 is a receptor for fibronectinand cytotactin. It recognizes the sequence R-G-D in its ligands.Internalisation of integrin alpha-V/beta-6 via clathrin-mediatedendocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts asa receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependentcell adhesion to FBN1 (PubMed:17158881).{ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607}. (Microbial infection) Integrin ITGAV:ITGB6 acts as areceptor for Coxsackievirus A9 and Coxsackievirus B1.{ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}. (Microbial infection) Integrin ITGAV:ITGB6 acts as areceptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).{ECO:0000269|PubMed:24367260}. Single-stranded DNA binding protein that interacts withthe region upstream of the MYC gene. Binds specifically to the DNAsequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNAreplication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGB6_RBMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGB6_RBMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGB6FLNB, FLNA, FN1, FHL2, MAPK1RBMS1POLA1, GRK5, NDUFA7, NABP2, PPIF, TIMM44, RPS19, PPIB, SCP2, MRPL53, PQBP1, SUGP1, RPL38, SNX3, SARNP, DNM2, UBE2I, SNRPC, MRRF, SRPRB, RFX5, HRSP12, UBQLN1, RRBP1, STX7, ZC3H11A, SBDS, TFCP2, HIST1H1A, FHL3, HNRNPA1, RBFOX2, XPO1, LPXN, HIST1H1E, RRS1, FAM136A, FGF8, HTRA4, SMAP2, SMAD9, ZNF143, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGB6_RBMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGB6_RBMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB6C4015557AMELOGENESIS IMPERFECTA, TYPE IH2UNIPROT
HgeneITGB6C0000786Spontaneous abortion1CTD_human
HgeneITGB6C0004364Autoimmune Diseases1CTD_human
HgeneITGB6C0008311Cholangitis1CTD_human
HgeneITGB6C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneITGB6C0023895Liver diseases1CTD_human
HgeneITGB6C0034067Pulmonary Emphysema1CTD_human
HgeneITGB6C0524910Hepatitis C, Chronic1CTD_human