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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17881

FusionGeneSummary for ITGB5_FGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB5_FGL1
Fusion gene ID: 17881
HgeneTgene
Gene symbol

ITGB5

FGL1

Gene ID

3693

2267

Gene nameintegrin subunit beta 5fibrinogen like 1
Synonyms-HFREP1|HP-041|LFIRE-1|LFIRE1
Cytomap

3q21.2

8p22

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-5testis secretory sperm-binding protein Li 217pfibrinogen-like protein 1hepassocinhepatocellular carcinoma-related sequencehepatocyte-derived fibrinogen-related protein 1liver fibrinogen-related protein 1
Modification date2018052320180519
UniProtAcc

P18084

Q08830

Ensembl transtripts involved in fusion geneENST00000296181, ENST00000461306, 
ENST00000398056, ENST00000522444, 
ENST00000398054, ENST00000381840, 
ENST00000381841, ENST00000427924, 
ENST00000518650, 
Fusion gene scores* DoF score8 X 8 X 6=3844 X 3 X 5=60
# samples 97
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ITGB5 [Title/Abstract] AND FGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-D6-A6EM-01AITGB5chr3

124620113

-FGL1chr8

17743080

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000296181ENST00000398056ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000522444ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000398054ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000381840ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000381841ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000427924ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000296181ENST00000518650ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000398056ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000522444ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000398054ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000381840ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000381841ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000427924ITGB5chr3

124620113

-FGL1chr8

17743080

-
intron-5UTRENST00000461306ENST00000518650ITGB5chr3

124620113

-FGL1chr8

17743080

-

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FusionProtFeatures for ITGB5_FGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB5

P18084

FGL1

Q08830

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor forfibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as areceptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. Has hepatocyte mitogenic activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGB5_FGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGB5_FGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGB5ANXA5, PTK2, CYR61, PAK4, ITGB3BP, ITGA3, PPARD, MERTK, MYC, PDIA3, ALB, SNTA1, EWSR1, SRSF9, EPHA2, EHMT2, MTUS2, KRT40, KRTAP10-9, KRTAP10-8, NOTCH2NL, ITGA5, ATP1B3, KLK5, MFGE8, EDIL3, SPP1, ZBTB17, PLP1, ADAM9, VTN, ST8SIA4, ADAM21, ADAM33, PRG3, ST8SIA3, INSL5, LRRC4, ITGAVFGL1VKORC1, BCL2L11, EPPK1, LSG1, ALDH5A1, NAA35, PXDN, AARS2, CARKD, RAVER1, TBC1D10A, PPIL2, MAP1S, UBR1, CWF19L2, AMMECR1L, COL14A1, DDB2, SORL1, GTF2H2, CMAS, TLE3, TLE1, NSUN2, FBXO38, MLLT4, ARHGEF2, OGFOD1, PPP1R1A, TSR3, DCAF16, NDUFS6, NUCB1, MAPRE2, C1orf198, TUT1, TUBE1, LOH12CR1, DNM1L, PLAT, PTPN23, COL4A2, FAM172A, ERCC3, ETHE1, DPYSL5, GOLM1, ZADH2, UBA5, GTF2H3, NIPSNAP3A, MMADHC, GTF2H1, TFIP11, TUBD1, LCMT2, CENPC, TCF25, SPATS2L, C16orf59, SLTM, C17orf59, PLEKHA7, ATXN2, RBM6, TRIP6, ANKLE2, RIPK1, EPS8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGB5_FGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGB5_FGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB5C0040128Thyroid Diseases1CTD_human
HgeneITGB5C3495559Juvenile arthritis1CTD_human