FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17880

FusionGeneSummary for ITGB4_USP37

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB4_USP37
Fusion gene ID: 17880
HgeneTgene
Gene symbol

ITGB4

USP37

Gene ID

3691

57695

Gene nameintegrin subunit beta 4ubiquitin specific peptidase 37
SynonymsCD104|GP150-
Cytomap

17q25.1

2q35

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-4CD104 antigenubiquitin carboxyl-terminal hydrolase 37deubiquitinating enzyme 37tmp_locus_50ubiquitin specific protease 37ubiquitin thioesterase 37ubiquitin thiolesterase 37ubiquitin-specific-processing protease 37
Modification date2018052720180523
UniProtAcc

P16144

Q86T82

Ensembl transtripts involved in fusion geneENST00000579662, ENST00000339591, 
ENST00000200181, ENST00000450894, 
ENST00000449880, ENST00000584558, 
ENST00000258399, ENST00000454775, 
ENST00000415516, ENST00000418019, 
ENST00000338465, ENST00000475553, 
Fusion gene scores* DoF score15 X 12 X 8=14403 X 3 X 3=27
# samples 163
** MAII scorelog2(16/1440*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ITGB4 [Title/Abstract] AND USP37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB4

GO:0009611

response to wounding

19403692

HgeneITGB4

GO:0031581

hemidesmosome assembly

12482924

TgeneUSP37

GO:0000082

G1/S transition of mitotic cell cycle

21596315

TgeneUSP37

GO:0016579

protein deubiquitination

14715245

TgeneUSP37

GO:0035871

protein K11-linked deubiquitination

21596315

TgeneUSP37

GO:0071108

protein K48-linked deubiquitination

21596315


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF871219ITGB4chr17

73750805

+USP37chr2

219432755

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000579662ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000579662ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000579662ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000579662ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000579662ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000579662ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000339591ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000200181ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000450894ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
5CDS-intronENST00000449880ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000258399ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000454775ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000415516ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000418019ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000338465ITGB4chr17

73750805

+USP37chr2

219432755

-
intron-intronENST00000584558ENST00000475553ITGB4chr17

73750805

+USP37chr2

219432755

-

Top

FusionProtFeatures for ITGB4_USP37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB4

P16144

USP37

Q86T82


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ITGB4_USP37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ITGB4_USP37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ITGB4_USP37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ITGB4_USP37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB4C1856934Epidermolysis bullosa with pyloric atresia9CTD_human;ORPHANET;UNIPROT
HgeneITGB4C0266159Pyloric Atresia2CTD_human
HgeneITGB4C0000786Spontaneous abortion1CTD_human
HgeneITGB4C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneITGB4C0013575Ectodermal Dysplasia1CTD_human
HgeneITGB4C0014527Epidermolysis Bullosa1CTD_human
HgeneITGB4C0017639Gliosis1CTD_human
HgeneITGB4C0036095Salivary Gland Neoplasms1CTD_human
HgeneITGB4C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneITGB4C0268374Adult junctional epidermolysis bullosa (disorder)1CTD_human;ORPHANET;UNIPROT