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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17866

FusionGeneSummary for ITGB4_ADK

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB4_ADK
Fusion gene ID: 17866
HgeneTgene
Gene symbol

ITGB4

ADK

Gene ID

3691

132

Gene nameintegrin subunit beta 4adenosine kinase
SynonymsCD104|GP150AK
Cytomap

17q25.1

10q22.2|10q11-q24

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-4CD104 antigenadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date2018052720180523
UniProtAcc

P16144

P55263

Ensembl transtripts involved in fusion geneENST00000579662, ENST00000339591, 
ENST00000200181, ENST00000450894, 
ENST00000449880, ENST00000584558, 
ENST00000539909, ENST00000286621, 
ENST00000372734, ENST00000541550, 
ENST00000467840, 
Fusion gene scores* DoF score15 X 12 X 8=144018 X 8 X 11=1584
# samples 1621
** MAII scorelog2(16/1440*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB4 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB4

GO:0009611

response to wounding

19403692

HgeneITGB4

GO:0031581

hemidesmosome assembly

12482924


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FJ-01AITGB4chr17

73753188

+ADKchr10

76074425

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000579662ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000579662ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000579662ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000579662ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
5CDS-intronENST00000579662ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000339591ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000339591ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000339591ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000339591ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
5CDS-intronENST00000339591ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000200181ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000200181ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000200181ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000200181ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
5CDS-intronENST00000200181ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000450894ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000450894ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000450894ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000450894ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
5CDS-intronENST00000450894ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000449880ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000449880ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000449880ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
Frame-shiftENST00000449880ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
5CDS-intronENST00000449880ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+
intron-3CDSENST00000584558ENST00000539909ITGB4chr17

73753188

+ADKchr10

76074425

+
intron-3CDSENST00000584558ENST00000286621ITGB4chr17

73753188

+ADKchr10

76074425

+
intron-3CDSENST00000584558ENST00000372734ITGB4chr17

73753188

+ADKchr10

76074425

+
intron-3CDSENST00000584558ENST00000541550ITGB4chr17

73753188

+ADKchr10

76074425

+
intron-intronENST00000584558ENST00000467840ITGB4chr17

73753188

+ADKchr10

76074425

+

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FusionProtFeatures for ITGB4_ADK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB4

P16144

ADK

P55263


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ITGB4_ADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ITGB4_ADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITGB4SHC1, EIF6, ERBB2IP, ALOX12, COL17A1, DST, SREBF2, ITGA3, ARRDC3, ATXN1, SMAD2, SMAD3, PLEC, JUP, HNRNPU, ATF2, ENPP2, LPAR1, SEL1L, ILK, HNRNPD, VCP, MYH13, TNRC6A, SGTB, GEMIN7, MYO19, KLC3, BAG6, PPP2R3C, SKI, EGFR, MUC5ACADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ITGB4_ADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

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RelatedDiseases for ITGB4_ADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB4C1856934Epidermolysis bullosa with pyloric atresia9CTD_human;ORPHANET;UNIPROT
HgeneITGB4C0266159Pyloric Atresia2CTD_human
HgeneITGB4C0000786Spontaneous abortion1CTD_human
HgeneITGB4C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneITGB4C0013575Ectodermal Dysplasia1CTD_human
HgeneITGB4C0014527Epidermolysis Bullosa1CTD_human
HgeneITGB4C0017639Gliosis1CTD_human
HgeneITGB4C0036095Salivary Gland Neoplasms1CTD_human
HgeneITGB4C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneITGB4C0268374Adult junctional epidermolysis bullosa (disorder)1CTD_human;ORPHANET;UNIPROT
TgeneADKC0036341Schizophrenia1PSYGENET
TgeneADKC0242184Hypoxia1CTD_human
TgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
TgeneADKC3714756Intellectual Disability1CTD_human